Gene Information

Name : lysS_2 (HMPREF0675_4656)
Accession : YP_003581799.1
Strain : Propionibacterium acnes SK137
Genome accession: NC_014039
Putative virulence/resistance : Unknown
Product : lysine--tRNA ligase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 1709644 - 1712889 bp
Length : 3246 bp
Strand : -
Note : identified by match to protein family HMM PF00152; match to protein family HMM PF01336; match to protein family HMM PF04329; match to protein family HMM PF04330; match to protein family HMM PF04331; match to protein family HMM TIGR00499

DNA sequence :
ATGAACATCGCCGCCCTACTCATCGTGTTACGCCTGGTGTTTAGCCGCACCACGTGGGTGGCTATCGCCAACAACGTGTT
CTCGTTGTTCATTTTCCCGGTTGACGGTTTCGGTTGGGCCGGTGTCGTGGTCCTGTTGGTGCTGTCGGACGCGCTGTCGC
GACGTAAAAGGTTCGCCTGGTGGGTGAGCCTCGTCGTGTTTGGGTTGATGTGGCTGGTGGCGGCCGCGTTCTTTATCATC
GTGGTCACCGAGGTTTTCATAGGTTGGCCGACAGACACCCTTAACGACGTTGATCTGGCGGGGTATCTGTTCAACGTGTT
TTCGGTTGGCTGGATCTTGGTGGCATTGTTGACTCATCGTCGCGACTTTGCTGCGCACACGGTTCGCGCCAATCTCGGAC
GAGCGGTCGTCGTACTCGTTGGCGGTCTGTTGGCTACCGGATTTATTGGGTGGCTATTGGTGTCCCTGACCGGTGGTGTT
GGACGGCCACGGAACCGCCTGGTGCACATCATTACTCGCATCCTTCAAGGTAGTGGAGCAGGTATCGCCCAGGAGCCGAC
GTCGCCGCACTGGGTGCAAGGTGTGGTCTCATTCCTGCTGGCCGTCGTGCTGGTGGCTGCGCTCGTCGTCATTTTGCGTT
CCCAACGCAATATCGCGATGATGAGCCTGTCTGACGAGCTGAGATTACGCCGCCTTCTTGACGAAAATCCGGCTGATTCG
CTGGGATATTTTGCCCTGCGCCGTGACAAGGCTGTCGTCTTTTCTCGCAACGGTCATGCCGCCGTCTGTTATCGCACGGA
GGCTGGGGTGGCGTTGGCGTCGGGTGACCCAGTTGGCCCGGTTGACCAGTGGCCCGGAGCCATTGACGCATTTCTTGAGG
TCGCCCACACCTATGGATGGGTTCCTGCCGTCGTTGGCACCTCAGAGGAAGGTGCGACGACATGGAACCAGGCCGGTTTG
AGGGCGATGCGCATCGGCGACGAAGCCATCATCTCCCCGGCTACGTTTAATCTCGATGATCCTGATCTCAAGCCGGTGCG
CCATACGGTCACGAAACTGCGCGCGATGGGATACACGACTCGGGTTCGACGCCATGAGGACATCAATCCGCAGGAGTTGC
ACAGCCTGATTGACCTGACTGATAAATGGCGTCAAAACGGCGACGAGCGCGGCTTCTCAATGGCGTTGTCTCGGTTGGGG
GACCCTCTAGATGGTCGATGTGTCATGGTGGAGGCGATCTACCCCGACGACGGCCCTCGCGCTGGTCAGACGGCCGGTAT
TCTGTCCTTTACACCATGGGGTAATGACGGCTTGTCCCTCGACGTCATGAGGCGAGATCTCGACGGAGCAGATAACGGTG
TGACTGAACTTATGGTCGCCGGACTCATGGCGGCCGGGCCAGAAATTGGCATTCGGCGGGTGTCCATGAATTTCGCGGTG
TTCCGCGAGGCTATTGAGGAAGGCGCTCGAGTGGGTGCTTCCCCGGTGCGTCGGCTTAACCGCTGGTTGGTACTGGTGGC
ATCGAAGTGGTTTCAGATTGAGCAGTTGTACCGTTCCAACGTCAAGTACAAGCCGAGCTGGCAGACCCGCTACCTTAATT
TCACTGACACCTCTGATCTGGCTCAGGTTGGTCTAGCAATGGGTATTGCTGAGGGTCAGCTCGATATTCCTAATTGGCTT
TACCCGGTGGAACCGCCGCCCCAGCCGATATATTCAATTAGCGGGCATCCAGAGATTGCCGAATTCCTGGCTGAAGAACG
CGCGCCAATTCTTCCGCAGCGTCGTCTTCCCGAACAGGTTCGTACTCGAATGGCGACCCGTGAGCGTCTTATTGAGTCGG
GGGTGGAGGCCTATCCGCCTGACTGTAAGCCTGACCACCGGCTGGGTGACGTCGCCGTCGAGCTGACTGGCCAGGAGATG
ACCGTTTCCGGACGGGTGGATGCCTGCCGTGACCACGGCGGGGTCATCTTCGTTGACCTCTTCGACTGGACAGGTGCCTG
CCAGCTAGTCATGGAACGTGACACCATGGGCGTCGACAGTCTGCGCGACTTCCGTCATGCGGTGTCTTTGGGAGATCACC
TCGTTGCGACTGGAACAGTTGGGGCATCCCGTAACGGGACGCTAAGTCTGGAGATGACGTCGTGGCGGCTAGCAGCGAAG
TCGTTGCGACCGCTGCCATCGAGAAGATCGGGATTCAATGACCCAGAGGCCAAGGTTCGTCAGCGTTATCTCGACCTCAT
CGTCAACCCCAGTGCGCGCGATCAGCTGCGTGCTCGCTCGAATGCCATCCGCGCGGTGCGAGAAACCCTGCTAAGTCACG
ACTACATCGAGGTTGAGACGCCGATTCTGCAGACGATCCACGGCGGGGCGAATGCGCGTCCATTCCACACCCACATCAAC
GCCTACGACCTGGACCTTTATCTGCGCATTGCCCCAGAGCTGTACCTCAAGAGGCTTATGGTCGGCGGGGCGGGACGAGT
TTTCGAGATTGGTAGGAACTTCCGCAACGAGGGTGCCGACGCTACCCATAATCCCGAATTCACGATGCTCGAGGCCTACC
AGGCCTATGGCGATTACGTCCAGATGCGTCACCTCACGAGGGAGATGATCCTGTCCGCAGCCCGCAACGCCACCGGTGGG
ACGGTCGTGCGCGGACGTGACCGCAAGGGTGTTGAGCATGAGATCGATTTGGCTAACGAATGGCATGTCATCACTGTCAA
CGAGGGAATCTCGCGCGGTTTGGGGGAGGAAGTTACTGCCGATACCCCCAAAGAGACGCTCATCGGGTACGCCAATAAGC
TCGGGATTGCGACTTTGCCGAAGTGGAGTCGAGGCGATGTCGTCCTGGAGTTGCACGAGCACTTGAGTGAGCATGTCACC
GTCGAACCGACCTTCTTCTGCGACTTCCCGACCGACGTCTCCCCGCTGACACGACAGCACCGCGATGACCCGCGACTGGC
CGAGAAATGGGATCTCATCATCTTCGGCTCCGAGGTGGGTACTGCCTATACGGAACTCGTCGATCCGGTGATCCAACGGG
AGCGGTTTACAGCCCAGTCCTTGCTCGCTGCGGGTGGCGATCCGGAGGCGATGGAGCTTGATGAGGACTTCCTGGAGGCT
CTCGAGTACGCGATGCCGCCTTCTGGCGGTATGGGCATGGGGCTGGATCGTCTGGTCATGATGCTGACGAATGCGTCAAT
TCGCGAGACGATTAGCTTCCCGCTGGTGCGTCCGCGCACCTTGTGA

Protein sequence :
MNIAALLIVLRLVFSRTTWVAIANNVFSLFIFPVDGFGWAGVVVLLVLSDALSRRKRFAWWVSLVVFGLMWLVAAAFFII
VVTEVFIGWPTDTLNDVDLAGYLFNVFSVGWILVALLTHRRDFAAHTVRANLGRAVVVLVGGLLATGFIGWLLVSLTGGV
GRPRNRLVHIITRILQGSGAGIAQEPTSPHWVQGVVSFLLAVVLVAALVVILRSQRNIAMMSLSDELRLRRLLDENPADS
LGYFALRRDKAVVFSRNGHAAVCYRTEAGVALASGDPVGPVDQWPGAIDAFLEVAHTYGWVPAVVGTSEEGATTWNQAGL
RAMRIGDEAIISPATFNLDDPDLKPVRHTVTKLRAMGYTTRVRRHEDINPQELHSLIDLTDKWRQNGDERGFSMALSRLG
DPLDGRCVMVEAIYPDDGPRAGQTAGILSFTPWGNDGLSLDVMRRDLDGADNGVTELMVAGLMAAGPEIGIRRVSMNFAV
FREAIEEGARVGASPVRRLNRWLVLVASKWFQIEQLYRSNVKYKPSWQTRYLNFTDTSDLAQVGLAMGIAEGQLDIPNWL
YPVEPPPQPIYSISGHPEIAEFLAEERAPILPQRRLPEQVRTRMATRERLIESGVEAYPPDCKPDHRLGDVAVELTGQEM
TVSGRVDACRDHGGVIFVDLFDWTGACQLVMERDTMGVDSLRDFRHAVSLGDHLVATGTVGASRNGTLSLEMTSWRLAAK
SLRPLPSRRSGFNDPEAKVRQRYLDLIVNPSARDQLRARSNAIRAVRETLLSHDYIEVETPILQTIHGGANARPFHTHIN
AYDLDLYLRIAPELYLKRLMVGGAGRVFEIGRNFRNEGADATHNPEFTMLEAYQAYGDYVQMRHLTREMILSAARNATGG
TVVRGRDRKGVEHEIDLANEWHVITVNEGISRGLGEEVTADTPKETLIGYANKLGIATLPKWSRGDVVLELHEHLSEHVT
VEPTFFCDFPTDVSPLTRQHRDDPRLAEKWDLIIFGSEVGTAYTELVDPVIQRERFTAQSLLAAGGDPEAMELDEDFLEA
LEYAMPPSGGMGMGLDRLVMMLTNASIRETISFPLVRPRTL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-157 46
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-157 46
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-157 46
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 3e-157 46