Gene Information

Name : cadA (BMQ_3137)
Accession : YP_003563593.1
Strain : Bacillus megaterium QM B1551
Genome accession: NC_014019
Putative virulence/resistance : Resistance
Product : cadmium-translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 3096376 - 3098937 bp
Length : 2562 bp
Strand : +
Note : -

DNA sequence :
ATGAAACACGAAGATAAAAAAAATCATCAGCATACCGGAAGCTGCTGCAGCGGATCTTCTTCACCAGAAATTGAAAGCAA
GACCTGCTGCTCCTCTTCTTCAGAAGCCGCATCTACTGAAGAGCCTTCTTCCTGCGGCACAAAGAGTCATGAACACAGTC
ACAGCTGCTGTTCAGATACCATTGCGTTAACGACCGACAAAGGCCAGCATTCTTGTTGCAGTGATCACGATATAGTATCA
GGCGACAGTGACATAGAAGAAACGGCTGAATACCGCGTATATGGAATGGATTGTCCTTCCTGCGCCGCGACGATTGAAAA
AAGTTTAAAAACATTAAACGATATTCAACACGTAACCCTCAACTATAATACAGGGAAGCTCCAGGTAGCGGCGGCAAGTG
AGTCAGCTCTGTTACTCATTCCAAGCTCAGTAGAAAAACTAGGGTTTAACATTGAGACTATCCAATCAAATAAAAAAATG
AAAACGTATTTGATTGAAGGAATGGACTGCGCGGCTTGTGCGAACACAATTGTGAATCATTTAAAAACAGTTCCTGCTGT
CAAAGATGTACGCGTTAACTTTTCAACGGGAAAAGCACAAATTGAGCACGATAACGAAGCGGATGACATTATTAAAGAAG
TATCTAAAGCTGGGTATACCGCTACTTTAGTAACCAGCAGCAGGCAGTCTGCTGAGTCGCGGCACCATAAAGGCCAAAAT
GGACCGATTGTTTTTTCGGGTATTCTCATCGCATTAGGTTTTATCGGTTCTCATACAGGAATTGCTTCTTATATGACAAC
TGTACTCTACGCTATTGCCATGATTGTTAGCGGATATAAACCGGCTAAAAGTGCTTATTACGGAATTAAAAGCCGTTCTT
TAGACATGAATGTTTTAATGACCGTTGCAGCACTTGGAGCAGCTGTTATTGGTGAGTGGCTTGAAGGTGCTACGGTCGTT
TGGCTATTTGCTTTAGGTGTTGCTCTACAAACAAGGTCGATTGAACAAACAAGAAACTCCATACGAGGTTTGATGGATTT
AGCTCCTTCTGAAGCATGGGTGAAAGAAAACGGCCAGCTGATTAAAAAAGCAGCGGAAGATATTTCAATCGGCACTACGA
TTGTCGTAAAGCCAGGAGACCGAATTCCGCTAGATGGTGAAATTATAAACGGCGAATCCAATATCAACCAAGCTCCTATT
ACAGGTGAATCTATTCCAGTTGATAAAATAATCGGTGATGCTGTTTATGCAGGCACCATTAACGAAAGCGGATCGTTAGA
AGTTAAGGTAACAAAGCTAGTCGAAGATACGACTATTTCTAAAATTATTCATTTAGTGGAAGAAGCACAGGAGAAAAAAG
CGCCTACTCAAGCATTTGTTGATAAATTTGCAACCATTTACACGCCTATCGTCTTTATTTTAGCTTTATTCATTATGGTC
ATCCCTCCCCTGTTTGATGGTGCATGGAGTGAGTGGTTTTACAAGGGGCTTGAATTATTAGTTGTGGCTTGCCCATGCGC
GCTAGTCATTTCTACTCCTGTCGCCATTGTATCTGCGATTGGAAACGCGGCGAAAAATGGTGTGCTCATTAAAGGCGGGA
CGTTTTTAGAAAAAGCTGGTGCAATCAATGCGATTGCTTTTGATAAAACAGGAACGCTAACAGAAGGTAAACCAGCCGTT
TCAGAGGTTGTTTCCCTTGCTGCTGAAGAAAATCAGCTTTTAGCGATAACAAAAACGCTTGAAGACTATTCGAATCATCC
CATTGCCCGTGCTATCGTGGATTATGCAGCGGAGAAAAAAGTCGATTCTTTACAAGGATCAAATTTTAAAATCCTTACAG
GAAAAGGCGTTCAGGCAACAATTCAAGAAACGGTTTATTACGCAGGTAATGCAAAATTATTCTCAGATTTAGGAACACCT
CTATCCCACTGCTGGTCTCATATTGAAAAGCTTCAAAACGAAGGTAAAACGATTATTATTGTCGGAACAGCTAAAAGTGT
TCTAGGTATTATTAGCGTAGCTGATACCATCAGACATACAACCGTATCTGCTTTAGAAAGCCTCAAACAAAACGGAATGC
AGCAAATTGTGATGTTAACCGGTGATAACGAAGGAACAGCTAAAATGATTGCCTCTGAGTCGCGGGTAGACCGCTATTTC
GCCGATTTGCTGCCTGAAGACAAAGTAAAAGCCATACAGCAGCTTCAACATGAAGGGTATCAAACGGCTATGGTTGGAGA
TGGAATTAATGACGCCCCTGCCCTCGCAACTGCTGATCTTGGCATTGCAATGGGCGGTGCTGGTACTGATACGGCCATGG
AAACAGCTGATATTGTTCTCATGGCAGACAATTTAGAAAAGCTTCCTCATACGATGAAGCTAAGCCGCAAAGCGTTAGCT
GTCATCAAACAAAACATTTGGTTTTCTATTATTGTTAAAGTCATTGCCTTAGCCTTTATCTTCCCAGGGTGGCTTACTCT
GTGGATTGCCGTTTTAAGCGATACAGGAGCAGCGCTACTTGTTATTTTAAACAGTCTTCGCTTACTCAAAATGAGAAAAT
AA

Protein sequence :
MKHEDKKNHQHTGSCCSGSSSPEIESKTCCSSSSEAASTEEPSSCGTKSHEHSHSCCSDTIALTTDKGQHSCCSDHDIVS
GDSDIEETAEYRVYGMDCPSCAATIEKSLKTLNDIQHVTLNYNTGKLQVAAASESALLLIPSSVEKLGFNIETIQSNKKM
KTYLIEGMDCAACANTIVNHLKTVPAVKDVRVNFSTGKAQIEHDNEADDIIKEVSKAGYTATLVTSSRQSAESRHHKGQN
GPIVFSGILIALGFIGSHTGIASYMTTVLYAIAMIVSGYKPAKSAYYGIKSRSLDMNVLMTVAALGAAVIGEWLEGATVV
WLFALGVALQTRSIEQTRNSIRGLMDLAPSEAWVKENGQLIKKAAEDISIGTTIVVKPGDRIPLDGEIINGESNINQAPI
TGESIPVDKIIGDAVYAGTINESGSLEVKVTKLVEDTTISKIIHLVEEAQEKKAPTQAFVDKFATIYTPIVFILALFIMV
IPPLFDGAWSEWFYKGLELLVVACPCALVISTPVAIVSAIGNAAKNGVLIKGGTFLEKAGAINAIAFDKTGTLTEGKPAV
SEVVSLAAEENQLLAITKTLEDYSNHPIARAIVDYAAEKKVDSLQGSNFKILTGKGVQATIQETVYYAGNAKLFSDLGTP
LSHCWSHIEKLQNEGKTIIIVGTAKSVLGIISVADTIRHTTVSALESLKQNGMQQIVMLTGDNEGTAKMIASESRVDRYF
ADLLPEDKVKAIQQLQHEGYQTAMVGDGINDAPALATADLGIAMGGAGTDTAMETADIVLMADNLEKLPHTMKLSRKALA
VIKQNIWFSIIVKVIALAFIFPGWLTLWIAVLSDTGAALLVILNSLRLLKMRK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-170 46
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 9e-171 46
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 6e-168 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_003563593.1 cadmium-translocating P-type ATPase BAC0092 Protein 1e-100 42