Gene Information

Name : Mrub_0004 (Mrub_0004)
Accession : YP_003505806.1
Strain : Meiothermus ruber DSM 1279
Genome accession: NC_013946
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 4406 - 5830 bp
Length : 1425 bp
Strand : +
Note : TIGRFAM: pyruvate kinase; PRIAM: Pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; SPTR: A7CAK5 Pyruvate kinase; KEGG: acr:Acry_0178 pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; PFAM: Pyr

DNA sequence : 
ATGGGACTCTTGAAACGAACCAAAATTGTGGCCACCCTGGGGCCCGCCTCGCGTTCGCCCGAAGTGATACGGGCCCTGAT
CGAGGCCGGCGTCGATGTTTTTCGCCTCAACTTTTCGCATGGCGTGCCCGAGGACCACCGGGCCTCGGTGCAGATGATCC
GGGAGGCCTCGAGCGCCCTCGGCCGCACCGTGGCCATCCTGCAAGACCTGCAAGGCCCCAAGATTCGCTGCGGGCGCTTC
CGCGAGGGGGCGGTGGAGCTTCAGCCAGGGCAAAAATTCATCATCACCGCCGAGCCCGTCGAGGGGGATGAAACCCGGGT
CTCGACCACCTACCGGGGTCTGCCCAACGATGTGACCCCAGGACAGATTCTGCTTCTGGATGATGGGAACATCCGACTGC
GGGTGGACGAGGTTCGCATCAACGACATCCACACCACCGTGCTGGTAGGGGGGCGGCTTTCCAACAACAAGGGCATCAAC
ATCCCCGGGGCCGACCTTTCGATCCCAGCCCTGACCGATAAAGACATCGACGATATCGCCCTGGGCGCCGAGCTCGAGGT
GGACTGGGTGGCCATTAGCTTTGTGCGCAGCCGCGACGACCTGCTGCTGGCCCGCCACTACCTGACCCGCCACAACTCCC
GCGCCCGGCTGATGGCTAAGATCGAGAAGCCCAGCGCGGTGGCCCGCTTCGACGAGATCCTCGAGGAGGCCGACGGCATC
ATGGTGGCCCGCGGCGACCTGGGGGTGGAGATGCCGCTGGAGGAGGTGCCGGCGGTGCAGAAGCGCATCATCCTCAAGTC
GGTGCAGGCTGGCAAGGCCGTAATTACCGCCACCCAGATGCTGGAGTCCATGATCAAAAACCCCAGCCCCACCCGCGCCG
AGGCCTCGGATGTGGCCAACGCCATCTTCGACGGCACCGATGCGGTGATGCTTTCGGCCGAGACCGCTGCGGGCCAGTAC
CCGGTCGAGGCGGTCTCGTTCATGACCCGGGTGGCCAAGACCATCGAGGCCACCCAGGAGTACAAAGACCGCCTCAACGC
CCTGCGCCCGCCGGCCACCCGCACCGTGCAGGACGCCATCGCTCGAGCTGTGGACGATGTGGTGGAGTCCACCGGGGCCA
AGGCCGTGGTGGTGTTCACCTCCAGCGGCGGGGCGGCCCGCCGGGTGGCCCGCACCCGGCCCCCGGTGCCGATTCTGGCC
CTGACCCCCAACCCCCACGTGCGCAACCAACTGGCCCTGGTCTCGGACGTGCTGCCCCTGCTGGCCCCCGACCCCAAAGA
CACCGACGATATGGTGCAGATTGCGGTGGCCAAGGCCAAGGAAACCGGCCTGGCCGAGGTGGGCGAGTATGTGGTGATTG
CCGCCGGGGTGCCCTTTGGGGTGCGGGGTACCACCAACATGATCCGGGTGGAGCGGGTTAGCTGA

Protein sequence : 
MGLLKRTKIVATLGPASRSPEVIRALIEAGVDVFRLNFSHGVPEDHRASVQMIREASSALGRTVAILQDLQGPKIRCGRF
REGAVELQPGQKFIITAEPVEGDETRVSTTYRGLPNDVTPGQILLLDDGNIRLRVDEVRINDIHTTVLVGGRLSNNKGIN
IPGADLSIPALTDKDIDDIALGAELEVDWVAISFVRSRDDLLLARHYLTRHNSRARLMAKIEKPSAVARFDEILEEADGI
MVARGDLGVEMPLEEVPAVQKRIILKSVQAGKAVITATQMLESMIKNPSPTRAEASDVANAIFDGTDAVMLSAETAAGQY
PVEAVSFMTRVAKTIEATQEYKDRLNALRPPATRTVQDAIARAVDDVVESTGAKAVVVFTSSGGAARRVARTRPPVPILA
LTPNPHVRNQLALVSDVLPLLAPDPKDTDDMVQIAVAKAKETGLAEVGEYVVIAAGVPFGVRGTTNMIRVERVS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 9e-76 44
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 5e-76 44
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 5e-76 44
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 9e-76 44
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 9e-62 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mrub_0004 YP_003505806.1 pyruvate kinase VFG0479 Protein 2e-76 44