Gene Information

Name : Mrub_2453 (Mrub_2453)
Accession : YP_003508224.1
Strain : Meiothermus ruber DSM 1279
Genome accession: NC_013946
Putative virulence/resistance : Unknown
Product : adenine-specific DNA-methyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.72
Position : 2505846 - 2507462 bp
Length : 1617 bp
Strand : -
Note : PRIAM: Site-specific DNA-methyltransferase (adenine-specific); PFAM: N-6 DNA methylase; InterPro IPR002296:IPR003356:IPR002052; KEGG: aba:Acid345_3758 N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; SPTR:

DNA sequence :
ATGCCGAGGCGAAAATCCAACCCGCAATCCACCCCAACCACCGCCGCCACCGTCGGCTACGAGGCCGAACTCTGGAAGAT
GGCCGATACCCTGCGCGGCAGCATGGACGCCGCCGAGTACAAGCACGTGGTGCTGGGCCTGATCTTCCTCAAGTACATCT
CCGACGCCTTCGAGGAGCTGCACAGGAAGCTCGAGGCCGAACGCGCGCAAGGCGCCGACCCCGAAGACCCCGACGAATAC
CGCGCCCAGAACATCTTCTGGGTGCCCCCCGAGGCCCGCTGGGCGCACCTGAAGGCCCAGGCCCGCCAGCCCACCATCGG
CCAGCTTGTGGACAACGCCATGGCCTGTATCGAGCGCGACAACCCCGCGCTCAAGGGCGTGCTGCCCAAGGAGTACGCCC
GCCCGGCGCTGGATAAAACACGCCTGGGGCAGCTTATAGACCTGATCAGCAACATCAAGGTGGGCGACGAAGAAGCCCGC
GCCAAGGACGTGCTGGGCCGGGTGTACGAATACTTCCTCTCGCAGTTTGCCAGCGCCGAGGGCAAGAAGGGAGGCGAGTT
CTACACGCCCCGCTGCGTGGTCAAGCTGCTGGTGGAGATGCTCGAGCCCTACCATGGCCGGGTCTACGACCCCTGCTGCG
GCTCGGCGGGTATGTTCGTGCAGTCGGTGGAGTTTATCCGCGCCCATGCGACCGGTAACGGCAACGGTGGCAGGGCCAAA
GCCGACATCTCGATCTACGGCCAGGAGTCGAACTACACCACCTGGCGGCTTGCGAAAATGAACCTTGCCATCCGGGGCAT
CGAGGGCCAGATCGCCCACGGCGACACCTTCCACAACGACAAGTTCCCCGACCTGAAGGCCGACTTCATTCTGGCTAACC
CACCCTTCAACGTCTCCGACTGGGGCGGCGAGCGCCTGCGCGACGACAAGCGCTGGCAGTACGGCGTGCCCCCGGTGGGC
AACGCCAACTTCGCCTGGGTGCAGCACATCGTGTACCACCTTTCCCCCACGGGCGTGGCCGGCTTCGTGCTAGCCAACGG
TTCGATGTCCAGCAACCAGTCGGGCGAGGGCGAGATTCGCAAGAACCTGATTGAAGCGGGACTGGTGGACTGCATGGTGG
CGCTGCCCGGCCAGCTCTTCTACTCGACGCAGATCCCGGCCTGCCTGTGGTTCCTCGCGCGCGACCGCAGCTCTCGTCCA
TACGGCGCTGCTGGCGCAGCGCCTGGGGGCAAGTTCCGCGACCGCCGCGGCGAGATTCTGTTTATTGATGCCCGCAAGAT
GGGCCGCATGGTAGACCGCACCCACCGCGAACTCACCGACGAGGACATCGCAAAGATTGCCAGCACCTACCACGCCTGGC
GCGGCGAAAAGGACGCGGGCGAATACCAGGACGTGCCCGGCTTCTGCAAAAGCGCCACCCTGGACGAGGTGCGCAAGCAC
GGCTACGTGCTCACGCCGGGGCGCTATGTGGGGGCCGAGGCGCAGGAAGATGACAGCGAACCGTTTGAGGAGAAGATGGC
GCGGCTGGTGGCGCAACTGCGCGAGCAGCAGGCCGAGGCCGCGAGGCTGGATAAGGCTATTGCTGCCAACCTGAAGGAGT
TGGGGTATGGGGGGTGA

Protein sequence :
MPRRKSNPQSTPTTAATVGYEAELWKMADTLRGSMDAAEYKHVVLGLIFLKYISDAFEELHRKLEAERAQGADPEDPDEY
RAQNIFWVPPEARWAHLKAQARQPTIGQLVDNAMACIERDNPALKGVLPKEYARPALDKTRLGQLIDLISNIKVGDEEAR
AKDVLGRVYEYFLSQFASAEGKKGGEFYTPRCVVKLLVEMLEPYHGRVYDPCCGSAGMFVQSVEFIRAHATGNGNGGRAK
ADISIYGQESNYTTWRLAKMNLAIRGIEGQIAHGDTFHNDKFPDLKADFILANPPFNVSDWGGERLRDDKRWQYGVPPVG
NANFAWVQHIVYHLSPTGVAGFVLANGSMSSNQSGEGEIRKNLIEAGLVDCMVALPGQLFYSTQIPACLWFLARDRSSRP
YGAAGAAPGGKFRDRRGEILFIDARKMGRMVDRTHRELTDEDIAKIASTYHAWRGEKDAGEYQDVPGFCKSATLDEVRKH
GYVLTPGRYVGAEAQEDDSEPFEEKMARLVAQLREQQAEAARLDKAIAANLKELGYGG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 1e-152 61
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 2e-152 61
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 2e-152 60
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 7e-122 50