Gene Information

Name : Thit_2216 (Thit_2216)
Accession : YP_003477989.1
Strain : Thermoanaerobacter italicus Ab9
Genome accession: NC_013921
Putative virulence/resistance : Resistance
Product : D-alanine/D-alanine ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : 6.3.2.4
Position : 2261124 - 2262203 bp
Length : 1080 bp
Strand : -
Note : TIGRFAM: D-alanine/D-alanine ligase; KEGG: tpd:Teth39_0187 D-alanyl-alanine synthetase A; PFAM: D-alanine--D-alanine ligase domain protein

DNA sequence : 
ATGGTAAAGAAGAGAATTGCTGTTTTATTTGGAGGACAATCAGGAGAACATGAGGTCTCTTTAATGTCTGCAAAGTCTAT
AATAAACAATCTCGATAAAGATAAATACGAGATTTACATGGTAGGTATTACAAAAAAAGGAGAATGGTATCTATATAGGG
GTGACGTAGAGAAAATAGAAACCGGAGAATGGGAAAAAGAAGGAATTCCTGCAACTATGGGAGCTTCTACAAAGTATAGA
GGAATAATAACTTTTGGAGAAGGAAAAAATGGTTTTTTTCCTATAGACGTGGTATTTCCTGTATTGCATGGCCCTAATGG
GGAAGATGGGACTATACAAGGGCTTTTAGAATTATTGAATATACCTTATGTAGGTGCTAATGTGCTTTCTTCTGCTTTAT
GCATGGATAAAGTTTTTACAAAAAGAATTTTTAAGGAAGCTGGATTGCCTACACCTGATTTTGTAGTAGTTTATAGAAAA
GAAATTGGGGATTTAGAAACTATTAAAAAGAAAATTGAGCACTTAGGATATCCTTGTTTTGTAAAACCAGCTAATTTGGG
ATCAAGTGTTGGTATTACCAAAGTTCACAACGAGGAAGAACTTCCTGGGGCCTTGAAATTAGCTGCAAAATATGATAGAA
AATTGTTGATAGAAAAAGGAATAGAGGCCAGAGAGATTGAATGCTCTGTTCTGGGGAATGAAAATCCTGAGGCTTCTGTT
GCGGGAGAAATTGTACCTTCAAATGAGTTTTATGATTACAATGCGAAATATTTTGATGGAGGGAAGTCACTTCTTTTAAT
ACCTGCTCCACTACCTGATGAAAAAATGGAAGAGATAAGAAAGCTTGCTATAAAAGCCTACAAAGCCTTGGATTTAAGAG
GCATGGCGAGAGTAGACTTTTTAATGGATAGAAATACAGGCACTGTTTACCTAAATGAAGTTAACACTATTCCGGGCTTT
ACGAAAATAAGCATGTATCCTAAACTATGGGAAGCAAGTGGAAAGTCCTATTCGGCATTATTGGATGACCTTATAAATTT
AGCAATAGAAAGTAATAATGAAAAATGTAGGGAATGGTGA

Protein sequence : 
MVKKRIAVLFGGQSGEHEVSLMSAKSIINNLDKDKYEIYMVGITKKGEWYLYRGDVEKIETGEWEKEGIPATMGASTKYR
GIITFGEGKNGFFPIDVVFPVLHGPNGEDGTIQGLLELLNIPYVGANVLSSALCMDKVFTKRIFKEAGLPTPDFVVVYRK
EIGDLETIKKKIEHLGYPCFVKPANLGSSVGITKVHNEEELPGALKLAAKYDRKLLIEKGIEAREIECSVLGNENPEASV
AGEIVPSNEFYDYNAKYFDGGKSLLLIPAPLPDEKMEEIRKLAIKAYKALDLRGMARVDFLMDRNTGTVYLNEVNTIPGF
TKISMYPKLWEASGKSYSALLDDLINLAIESNNEKCREW

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 1e-55 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase AY489045.gene.p01 Protein 6e-56 42
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase AF130997.1.orf4.gene Protein 6e-54 42
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase AF277571.gene.p01 Protein 6e-56 42
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase AF162694.gene.p01 Protein 8e-56 42
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase U00456.gene.p01 Protein 5e-56 41
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase U35369.1.gene6.p01 Protein 5e-56 41
Thit_2216 YP_003477989.1 D-alanine/D-alanine ligase AE016830.1.gene2250. Protein 5e-56 41