Gene Information

Name : clpC (HMPREF0868_0472)
Accession : YP_003474803.1
Strain : Clostridiales genomosp. UPII9-5
Genome accession: NC_013895
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1340832 - 1343606 bp
Length : 2775 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGAAGATAATTCTTACCGAAAGCACGCAACATGTTTTGCAGGTGGCCAACCAGCTAGCTAAATGTTATCGCATAGGCGA
AATTGGCACTGAATATTTGTTGGGCGCTATGATTAAAGAGAAAAAAATGGGTAATGCCGATCTGATTTTGCAGAAACACG
GCATAGATTTTGCTCAATACAACGCGGTTTTGGCCAAAATTAACCAAATGGAACCGCAAGATTTTAATTGGCCGGAACAC
GAAGACTTGGAACGCATCGTGGCCAAGCTTTCGCAACGTGCCAAACAGATATTTGATCGAGCCGTACTTATGGTGCACAT
GGGCAATAAGCCGCTGACAACTACCGCCCTACTTATTTCTCTACTCGAAGCAGGGGATTCAGTGGCGATCAGGATTTTGC
ATAGCCTAGGTCTGTCGCTAGAGGTGTTCCAACGGGAGTTTATGGCTTTGCAGGAAGAGAACGGGGCCGATCCGGAATTG
GCGGGCTATAACGAAGCTGAAGATGATGAGTCAGAGGAAGAAAGTGAGGATATTTCTGCAGAAGATAACGCAGTGATGAA
GCAAGGTGGCCAGGGAAAACATGGCGGCAATGCGTTGAAGAAGTTCGGCAATGATTTGACGGAACGCTGCCGTAAGCAAA
AAGTTGATCCGGTCATCGGGCGTAATGAGGAAATAAACCGCGTAATGCAAATCCTATGCCGTCGCACCAAAAACAACCCT
TGCTTGATTGGCGAGCCGGGCGTTGGTAAAACTGCAGTGGTGGAAGGACTGGCTCAGAAAATTGCCGCCGGAGATGTGCC
GGATATTCTGCAAGATAAGCGGATAATCAGCATTGATATGGGCGGTATGTTGGCCGGAGCCAAATATAGAGGTGAGTTTG
AGGAACGTTTGAAGAAAGTTTTGGCTGAGGCCGGGCAAGCTGGGGATGTAATTCTATTCATTGATGAACTTCACACCCTA
ATCGGTGCCGGGGCCGGTGAAGGATCGATTGACGCGGCCAATATTATGAAACCGATGCTGGCCAGAGGCGAGCTCCAAGT
TATCGGTGCCACTACCTTGAACGAATATCGTAAATATATCGAAAAGGATGCGGCTTTGGAGCGGCGGTTCCAGCCGGTTA
CCGTTGAAGAACCGTCGGAAGAGGACACTTTGGCAATTTTGCGGGGCGTACGGGAAAAATATGAAAACCATCACAAAGTG
AAAATAACCGATGCAGCTTTGGAAGCGGCTGTCAAACTTTCCGTCCGCTATATCAATGACCGTTTCCTGCCGGACAAAGC
CATTGATCTGATGGATGAGGCAGCGGCAAAACTACGCTTGGCGGGTTCTGGTAATAACAAACAGCTGCAAAAATTGCAAA
AAGACCTTGATAAGCTGAAAGATGAAAAAGAACGGGCCGCTGCGGCTGAAAACTTTGAACAGGCGGCTGAGCTGTTGCAG
AAACAGCAGGCGTTGGAAAATAAGCTCGTCAAAGTGAAGGCGGCAAAAAAGCATGAGCCGAGCGATGCCAAGGCTGTTTT
GACGGAAGAAAATATTGCAGATATCGTGGCCGGTTGGACCGGAATCCCGGTAAAGCGGCTTACAGAAAATGATACAACTA
GATTAAAAAATCTTGATAAGGAACTGAAGAGTCGTGTTATAGGTCAGGATGCCGCGGTCGATGCGGTGGTACAGGCCATC
CGGCGTGGTCGTCTCGGTTTGAAAGATCCGCAGCGCCCCATCGGTTCGTTCCTGTTCCTCGGTACTACAGGTGTAGGTAA
GACTGAACTGGCTAAGGCTTTAGCTGAAGTCATGTTTGGTGATCCTAACGCGATGATCAGGCTTGATATGTCGGAATATA
TGGAAAAATTTGATGTATCTAAGCTCATCGGTTCGCCGCCGGGATATGTCGGTTATGATGAGGGCGGCCAATTGACCGAA
AAAGTGAGACGCCATCCGTATTCGGTAATTCTGTTTGATGAGATTGAAAAAGCGCATCCGGATGTTTTCAACGCCTTACT
GCAAATTTTGGAAGATGGCCGGTTGACGGACAGCCAGGGACGTACGGTTAAGTTTGCCAACACGATCATCATCATGACCT
CGAACTTGGGAGCCAAGTTATTGCTGAACGGCAACAAGCGGATCGGCTTTGACTTTGCCGGTAAAGGTGGCGAACCAGAA
CAGAATGATGACCGTAATTTGTACGGCGGTCGCAGCTATCAAGAGGCGGCTGATCTGGTCATCGCTGAAGCGAAACGTAC
TTTCAATCCGGAATTTATCAACCGTATTGATGAAATTCTATTCTTTAAGATGCTGGATAAAAAGGCAATGCGCCAAATTG
TTGACCTTATGCTCAAAGGTTTGGCGAAACGTATCAGTGAGCTCGGGATTAAGCTTACCGTAACTGATGCTGCAGCTGAT
CGCTTGGCTGTTGAAGGCTATGACAGCTTGTACGGTGCAAGGCCATTGCGTCGGACGATTCAGAATCGAGTCGAGGATGA
GTTCTCACAGGCGATGCTTGATGGTACAATTAAAAAAGGTGACGTGGCGGAGGTCGATATTGTCAAACAAGGGAAGGATG
TTAAGTTTGTCGTTCGGCCGCAAGGAAGTGAGCGCACTACAGAAAGTAAGGGATCAGATTCCGATTCTGATGCGTCCGCC
GATTCTGCCGCCCCAACCAATCAAGCTGATAAATCAGCAGGTGGTTCGATAGAACATCCGTACCAGGTATCCAGCGATTC
GTCGGCTGAGCCTAAGGACACGGCAAAGGATGATAAGTCCAAGTCGGAAGATTAA

Protein sequence :
MKIILTESTQHVLQVANQLAKCYRIGEIGTEYLLGAMIKEKKMGNADLILQKHGIDFAQYNAVLAKINQMEPQDFNWPEH
EDLERIVAKLSQRAKQIFDRAVLMVHMGNKPLTTTALLISLLEAGDSVAIRILHSLGLSLEVFQREFMALQEENGADPEL
AGYNEAEDDESEEESEDISAEDNAVMKQGGQGKHGGNALKKFGNDLTERCRKQKVDPVIGRNEEINRVMQILCRRTKNNP
CLIGEPGVGKTAVVEGLAQKIAAGDVPDILQDKRIISIDMGGMLAGAKYRGEFEERLKKVLAEAGQAGDVILFIDELHTL
IGAGAGEGSIDAANIMKPMLARGELQVIGATTLNEYRKYIEKDAALERRFQPVTVEEPSEEDTLAILRGVREKYENHHKV
KITDAALEAAVKLSVRYINDRFLPDKAIDLMDEAAAKLRLAGSGNNKQLQKLQKDLDKLKDEKERAAAAENFEQAAELLQ
KQQALENKLVKVKAAKKHEPSDAKAVLTEENIADIVAGWTGIPVKRLTENDTTRLKNLDKELKSRVIGQDAAVDAVVQAI
RRGRLGLKDPQRPIGSFLFLGTTGVGKTELAKALAEVMFGDPNAMIRLDMSEYMEKFDVSKLIGSPPGYVGYDEGGQLTE
KVRRHPYSVILFDEIEKAHPDVFNALLQILEDGRLTDSQGRTVKFANTIIIMTSNLGAKLLLNGNKRIGFDFAGKGGEPE
QNDDRNLYGGRSYQEAADLVIAEAKRTFNPEFINRIDEILFFKMLDKKAMRQIVDLMLKGLAKRISELGIKLTVTDAAAD
RLAVEGYDSLYGARPLRRTIQNRVEDEFSQAMLDGTIKKGDVAEVDIVKQGKDVKFVVRPQGSERTTESKGSDSDSDASA
DSAAPTNQADKSAGGSIEHPYQVSSDSSAEPKDTAKDDKSKSED

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 5e-160 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_003474803.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 9e-175 53
clpC YP_003474803.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 9e-146 50