Gene Information

Name : Kvar_0681 (Kvar_0681)
Accession : YP_003437623.1
Strain : Klebsiella variicola At-22
Genome accession: NC_013850
Putative virulence/resistance : Resistance
Product : cystathionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 710552 - 711700 bp
Length : 1149 bp
Strand : -
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: kpe:KPK_0708 cystathionine beta-lyase

DNA sequence :
ATGTCATCTATCCACACCCTGAGCGTACATAGCGGAACCTTCACCGACAGCCACGGCGCAGTGATGCCGCCGATTTACGC
CACCTCCACTTTTGCTCAGCCGGCGCCGGGGCAGCATACCGGCTATGAATATTCCCGCAGCGGGAACCCTACCCGCCACG
CGCTGGAGACGGCGATCGCCGACCTGGAAAACGGCACGCGCGGCTACGCGTTCGCCTCCGGGCTGGCCGCCATCTCCACC
GTGCTGGAGCTGCTGGATAAGGACAGTCACCTGGTGGCGGTCGATGATGTGTATGGCGGCACTTACCGCCTGCTGGAAAA
CGTGCGCCGCCGTAGCGCTGGTCTGCAGGTGAGCTGGGTGAAACCCGACGACCTGAAGGGGATTGAAGCGGCTATCCGCC
CCGATACGCGCATGATCTGGGTGGAAACGCCCACCAACCCGCTGCTGAAGCTGGCGGATCTCAGCGCCATCGCCGCCATC
GCGCGACGCCATAACCTGATCAGCGTCGCCGATAACACCTTCGCCTCGCCGGCGATCCATCGCCCGCTGGAGCATGGATT
TGATATTGTGGTGCACTCCGCGACCAAATACCTCAACGGCCATTCCGATGTCGTCGCCGGCCTGGCGGTGGTTGGCGATA
ACTCCGAGCTCGCGGAAAAGCTTGGCTATCTGCAGAATGCGGTAGGCGGGGTACTTGACCCGTTCAGCAGCTTCCTGACG
CTACGTGGTATCCGTACCCTGGCGCTGCGGATGGAGCGCCACAGCGCGAACGCGCTGCAGCTCGCCGAATGGCTGGAACA
GCAGCCGGAAGTGGAGCGAGTCTGGTTCCCCTGGCTGGCCTCGCACCCGCATCATCAGTTGGCGCGGCAGCAAATGGCGC
TGCCCGGCGGCATGATTTCGGTGGTGGTGAAGGGCGATGAAGGTTACGCCGAGCGCATTATCAGCAAGCTGCGCTGGTTT
ACGCTTGCGGAGAGCCTGGGCGGCGTGGAGAGTCTGGTGAGCCAGCCCTTCAGCATGACCCATGCCTCGATCCCGCTGGA
GAAACGTCTGGCGAATGGCATCACGCCCCAGCTGATCCGCCTGTCGGTGGGGATCGAAGATCCCAACGATCTGATTGCCG
ACTGGCAGCAGGCGCTGCGGGAGGAGTGA

Protein sequence :
MSSIHTLSVHSGTFTDSHGAVMPPIYATSTFAQPAPGQHTGYEYSRSGNPTRHALETAIADLENGTRGYAFASGLAAIST
VLELLDKDSHLVAVDDVYGGTYRLLENVRRRSAGLQVSWVKPDDLKGIEAAIRPDTRMIWVETPTNPLLKLADLSAIAAI
ARRHNLISVADNTFASPAIHRPLEHGFDIVVHSATKYLNGHSDVVAGLAVVGDNSELAEKLGYLQNAVGGVLDPFSSFLT
LRGIRTLALRMERHSANALQLAEWLEQQPEVERVWFPWLASHPHHQLARQQMALPGGMISVVVKGDEGYAERIISKLRWF
TLAESLGGVESLVSQPFSMTHASIPLEKRLANGITPQLIRLSVGIEDPNDLIADWQQALREE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-81 50
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-83 50
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 9e-59 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Kvar_0681 YP_003437623.1 cystathionine gamma-lyase BAC0207 Protein 7e-67 45