Gene Information

Name : Kvar_3596 (Kvar_3596)
Accession : YP_003440508.1
Strain : Klebsiella variicola At-22
Genome accession: NC_013850
Putative virulence/resistance : Resistance
Product : acriflavin resistance protein
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0841
EC number : -
Position : 3770604 - 3773669 bp
Length : 3066 bp
Strand : +
Note : PFAM: acriflavin resistance protein; KEGG: kpe:KPK_3786 RND transporter hydrophobe/amphiphile efflux-1 (HAE1) family

DNA sequence :
ATGGACATTTCCCGTCAGTTTATTAACAACCCGACCCGCGTCTGGTTAGCCATTTTGCTGTTGGGGGTGGGTGGCCTGTT
CGCCCTGCTCAATATTGGCCGCCTGGAAGATCCCGCCTTCACCATCAAAACGGCGGTGATCGTCACCCACTACCCTGGCG
CGTCCGCTCAGCAGGTGGAGGAGGAGGTGACCCTGCCGCTGGAAAACGCGATTCAGCAGCTTCCCTCGCTGGATAACGTC
AGCTCCATCTCCTCGAATGGCTTATCGCAAATTACAGTGAATATTGCTTCGCAGTACCATTCCAGCGAACTGCCGCAAAT
CTGGGATGAGCTGCGTCGCCGCGTCGGTGACGCCAGCCGGCTTTTTCCCCCGGGGGTAGTCCCCTCCTTCGTCAATGATG
ACTTTGGCGATGTGTTTGGCTTTTTCTTCGCCATTTCGGGCGACAGTTTTACCAATCCTGAGCTGGTGCGCTATGCCGAG
CAGTTGCGCCGTGAGCTGGTGCTGGTGCCGGGCGTCGGCAAAGTCGCCATTGGCGGCGCGATTCCACAGCAGATCAATGT
TGATATCTCGCTGGCGAAAATGGCGGCGCGCGGTATTACGCTTAACCAGCTTGCCGCTATCCTGACCCGGCTCAACGTGG
TATCCAGCGCCGGGGAGATCCGCGCCGGCAGCGAATCGATCCGCCTTCACCCCACCGGGGAGTTTCAGGATATCGATGAA
CTGGGGGATCTTCTGGTCAGCCCTCATGGCGCCAGCGCCACCACCCGACTACGGGATATTGCCACGTTGTCGCGCGGGCT
GACCGACTCTCCCTCCAGTATCTATCATGCCAACGGCCGCCAGGCGGTGACCATGGGGGTCTCCTTTATCCCTGGCGTTA
ACGTCATTGACGTGGGGCATGCCCTCGAAGCCCGACTTCAGCAGATGGCCGCCGATAAACCGGCGGGTATCGACATCGCC
ATTTTTTACGATCAGGCGGCAGAGGTCGCCCACTCGGTCAATGGCTTTATTACCAACTTCCTGATGGCCCTGGCGATCGT
CGTCGGCGTGCTGCTGGTGTTCATGGGGGTGCGCAGCGGGATCATTATTGCTTTGTCGCTGGCGCTCAACGTCCTCGGCA
CTCTGCTTATCATGTATATCTGGGGGATCGAGTTACAGCGAATCTCCCTCGGGGCGCTGATCATCGCCCTGAGTATGTTG
GTGGACAATGCCATTGTCATTGTCGAAGGGGTGCTGATCGCCCGCCAGCAAGGATCTCCGCTGCTGGGCGCGATTAATTA
TGTGATCCGCCGCTCCGCCCTGCCGCTGCTCGGCGCCACCGTTATTGCCATCCTCGCCTTCGCGCCAATTGGCCTTTCCC
AGGACTCCACCGGGGAGTATTGCAAATCCCTGTTCCAGGTGCTGCTGATCTCCCTGATGCTCAGCTGGTTTTCCGCCCTG
ACCATCACGCCGGTACTCATCAAGTGGTGGTTGTTTAAAAACGCCCCGTCGGCCGAGGCGCCGAAGGAAAAAGCCGATCC
CTACCGCGGCCGCTTCTATCGCGGCTATCAGCAGACGCTGCGAATACTGCTGCAGCAAAAGACCCTGACGCTGGTGCTGA
TGGGCGCGCTGTTAGCCGGGGCGATCTGGGGCTTCACCTTCGTCCGGCAGAATTTCTTTCCGTCATCGAATACGCCCATT
TTCTTTGTCGACCTGTGGTTGCCCTACGGTACCGATATTAACGCCACCGAGCAGATGACCCGCGATATTGAGCGGTCGAT
CGCCAGCCAGCCGGGGGTGGCTACCACCGTCTCCACCATTGGCCAGGGCAGTATGCGATTTATTCTCACCTACAGCGGGC
AGCGCCAGTACAGCAACTACGCGCAGATTATGGTGCGGATGGACGACCAGCGCAGTATCGCCCCCGTCACCCGCCACGTC
GAGGCCTGGATTGCCAGAAACTACCCGCAGGTGAACGCCAGCACCAAACGCATTATGTTCGGCCCGTCCGGCGATAGCGC
GATTGAAGTGCGCATTAAGGGCCCTGATCCGGATACTCTGCGCGCGCTGGCCAGTCAGGTGGGCGACATTCTCGCCGCGG
ATCCGGCGACCGACAGCGTACGTAACGACTGGCAGAACCGCAGCAAGGTGATCCGCCCGCAATACTCTCTGGCGTTGGGA
CGTGAGCTGGGGGTGGATAAACAGGATATTGATAGCGCGCTGGAGATGAATTTCTCCGGCAGTCGCGCCGGGTTATATCG
CGAGGGCGCCGACCTGCTGCCGGTTATCGTCCGTCCGCCGGAAGCGGAGCGACAGGATGCCAATCACCTGAATAACGTGC
TGGTCTGGAGCCAGAGCCGGCAGCAGTATATTCCGTTGAGTAACGTCATCCATGGCTTCTCGCTGGAGTGGGAAGATCCA
TTGATTCTCCGTCGCGATCGCACCCGCGTGCTTACCGTTCAGACCGACCCCAGCCCGCAAAGCGGCCAAACGTCGGGCGA
TATCCTTGCCAGAGTGAAACCGCGCATTGACGCGCTGACGCTGCCGCATGGCTACCGCATCGAATGGGGCGGCGATGCGG
AAAACTCCAGTGAAGCGCAGCAAGGGCTGTTCACGACCCTACCGCTTGGCTATCTGGTGATGTTTATCATTACGGTGCTG
ATGTTCAGTTCGCTGAAAAAGGCTGTTGCCATCTGGCTGACCGTCCCGCTGGCGCTGATCGGCGTCACGCCCGGTTTTTT
GCTGACCGGCATCCCTTTCGGCTTTATGGCCTTAATCGGCCTGCTTAGCCTCAGCGGTATGCTGATCCGCAACGGCATTG
TGCTGGTGGAAGAGATAGAGCAACAAAAACAGGAGAAAGATCAAAGACAAGCAATCATTGATGCGGCAACCTCTCGTCTG
CGGCCGATCCTGCTGACCGCCTTTACTACTGTGCTTGGCCTTGCCCCGCTGCTGCGCGATGTCTTTTTCCAGAGTATGGC
GGTGGTGATCATGTTCGGCCTCGCCTTTGCCACCGTACTGACGCTACTGGTTCTGCCGGTAATTTACGCTTGCTTCCACC
ATAAGGATATGACGCCTCAACGATGA

Protein sequence :
MDISRQFINNPTRVWLAILLLGVGGLFALLNIGRLEDPAFTIKTAVIVTHYPGASAQQVEEEVTLPLENAIQQLPSLDNV
SSISSNGLSQITVNIASQYHSSELPQIWDELRRRVGDASRLFPPGVVPSFVNDDFGDVFGFFFAISGDSFTNPELVRYAE
QLRRELVLVPGVGKVAIGGAIPQQINVDISLAKMAARGITLNQLAAILTRLNVVSSAGEIRAGSESIRLHPTGEFQDIDE
LGDLLVSPHGASATTRLRDIATLSRGLTDSPSSIYHANGRQAVTMGVSFIPGVNVIDVGHALEARLQQMAADKPAGIDIA
IFYDQAAEVAHSVNGFITNFLMALAIVVGVLLVFMGVRSGIIIALSLALNVLGTLLIMYIWGIELQRISLGALIIALSML
VDNAIVIVEGVLIARQQGSPLLGAINYVIRRSALPLLGATVIAILAFAPIGLSQDSTGEYCKSLFQVLLISLMLSWFSAL
TITPVLIKWWLFKNAPSAEAPKEKADPYRGRFYRGYQQTLRILLQQKTLTLVLMGALLAGAIWGFTFVRQNFFPSSNTPI
FFVDLWLPYGTDINATEQMTRDIERSIASQPGVATTVSTIGQGSMRFILTYSGQRQYSNYAQIMVRMDDQRSIAPVTRHV
EAWIARNYPQVNASTKRIMFGPSGDSAIEVRIKGPDPDTLRALASQVGDILAADPATDSVRNDWQNRSKVIRPQYSLALG
RELGVDKQDIDSALEMNFSGSRAGLYREGADLLPVIVRPPEAERQDANHLNNVLVWSQSRQQYIPLSNVIHGFSLEWEDP
LILRRDRTRVLTVQTDPSPQSGQTSGDILARVKPRIDALTLPHGYRIEWGGDAENSSEAQQGLFTTLPLGYLVMFIITVL
MFSSLKKAVAIWLTVPLALIGVTPGFLLTGIPFGFMALIGLLSLSGMLIRNGIVLVEEIEQQKQEKDQRQAIIDAATSRL
RPILLTAFTTVLGLAPLLRDVFFQSMAVVIMFGLAFATVLTLLVLPVIYACFHHKDMTPQR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0395_A1355 YP_001217299.1 AcrB/AcrD/AcrF family transporter Not tested VPI-2 Protein 2e-166 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Kvar_3596 YP_003440508.1 acriflavin resistance protein BAC0428 Protein 0.0 50
Kvar_3596 YP_003440508.1 acriflavin resistance protein BAC0519 Protein 0.0 49
Kvar_3596 YP_003440508.1 acriflavin resistance protein BAC0526 Protein 0.0 47
Kvar_3596 YP_003440508.1 acriflavin resistance protein BAC0425 Protein 1e-166 41