Gene Information

Name : Kvar_3106 (Kvar_3106)
Accession : YP_003440023.1
Strain : Klebsiella variicola At-22
Genome accession: NC_013850
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : -
Position : 3237310 - 3239256 bp
Length : 1947 bp
Strand : -
Note : KEGG: kpe:KPK_3236 DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein

DNA sequence :
ATGCGGTTGTTTATTGCGGAAAAACCGAGTCTCGGTCGGGCTATCGCCGATGTGTTGCCTAAACCGCACCGCAAAGGCGA
TGGCTATATTGAGTGCGGCAACGGGCAGGTGGTCACCTGGTGTATCGGCCATCTGCTGGAGCAGGCGCAGCCGGACGTCT
ATGACAGCCGCTATGCCCGCTGGAATCTCACCGACCTGCCGATTGTGCCGGAGAAATGGCAGCTACAACCCAAACCCTCG
GTCACCAAACAGCTCAATGTGATCAAGCGTCTGCTTGGCGAGGCGCAGGAAGTGATCCATGCCGGCGACCCCGACCGTGA
GGGGCAGCTGCTGGTGGACGAAGTACTCGATTACCTGCAGCTGGCGCCGGAGAAGCGTCAGCAGGTGCAGCGCTGTCTGA
TTAACGATCTCAACCCGCAGGCGGTGGAGCGGGCGATCAATCGCCTGCGCGCCAACAGCGAGTTCGTGCCGCTCTGCGTG
TCGGCGCTGGCGCGGGCGCGTGCCGACTGGCTGTACGGCATCAATATGACCCGCGCCTATACTCTGCTGGGGCGCAACGC
CGGCTATCAGGGGGTACTGTCCGTGGGGCGGGTGCAGACCCCGGTACTTGGCCTGGTGGTTCGCCGTGATGAAGAGATTG
AAAACTTCGTCGCCAAAGACTTCTTCGACGTGAAGGCGCATATCGTCACGCCGCAGGAGGAACGTTTTGTCGCCACCTGG
GTGCCAAGCGAAGCCTGCGAACCTTATCAGGATGAAGAAGGGCGTCTGCTGCATCGTCCACTGGCTGAGCACGTGGTTAA
GCGCATCGAAGGCCAGCCGGCGCTGGTGACCGGCTATAACGATAAGCGCGATTCCGAACCCGCGCCGCTGCCATTCTCGC
TGTCGGCGCTACAGATTGAGGCGGCCAAACGTTTCGGCTTCAGCGCGCAAAACGTGCTGGATATCTGCCAGAAGCTGTAC
GAAACCCACAAGCTCATTACCTACCCGCGTTCGGATAGCCGCTACCTGCCGGAAGAGCACTTCGCCGGCCGTCATGCGGT
GCTGAATGCGATTGCCGTCCATGCGGCGGACCTGCTGCCGCAGCCGGTGATGGATCCGGAGATCCGCAACCGCTGCTGGG
ATGATAAAAAGGTCGATGCGCACCATGCGATTATCCCGACCGCCCGCAGCAGCCAGGTCAAGCTCACCGATAACGAAGCG
AAGGTCTACCACCTGATCGCCCGGCAGTATCTGATGCAGTTCTGCCCGGACGCGGTGTTCCGCAAATGCCAGATTGACCT
CGAGATCGCCAACGGCAAGTTTGTCGCCAAGGCGCGTTTTCTGGCAGAGGCTGGCTGGCGGACGCTGCTGGGCAGCAAAG
AGCGCGATGAAGAGAACGACGGCACGCCGCTGCCGGTGGTGGCCAAAGACGATGAACTGCTGTGCGAGAAGGGCGAAGTG
GTGGAGCGTCAGACGCAGCCGCCGCGCCACTTCACCGACGCCACGCTGCTGTCGGCGATGACCGGGATTGCCCGTTTCGT
GCAGGATAAAGATCTGAAGAAGATCCTCCGCGCCACCGACGGTCTCGGCACAGAAGCGACCCGCGCCGGGATTATCGAGC
TGCTGTTTAAGCGCGGTTTCCTGACCAAAAAGGGGCGTTATATCCACTCCTCGGACGCTGGCCGGGCGCTGATTCACTCC
TTGCCGGAGATGGCCGCGCGTCCGGATATGACCGCCCACTGGGAATCGGTCCTGACGCAGATCAGCGAAAAGCAGTGCCG
CTATCAGGACTTTATGCAGCCGCTGGTGGGGACGCTGTTCCAGCTGATCGATCAGGCACGGAGCACGCCAGTGCGCCAGT
TCCGCGGCCTGGCCGCGCCGGGCGGGGCGAAAAAGTCGTTCAGCAAAGGTAAAGGCAAGCCGAAAGGGAAAAAAGCGGCA
GACGATGCTGCGCCGCCGCCGCAGTAA

Protein sequence :
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPKPS
VTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCV
SALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATW
VPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPALVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLY
ETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEA
KVYHLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKDDELLCEKGEV
VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSSDAGRALIHS
LPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLAAPGGAKKSFSKGKGKPKGKKAA
DDAAPPPQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 1e-110 41
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 1e-110 41
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 8e-111 41
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 9e-107 41
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 1e-102 41
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 3e-110 41