Gene Information

Name : BpOF4_20564 (BpOF4_20564)
Accession : YP_003429000.1
Strain :
Genome accession: NC_013792
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 112964 - 114604 bp
Length : 1641 bp
Strand : -
Note : COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

DNA sequence : 
ATGAATAAATTCAAGATAAATATTCAAGGAATGACTTGTACGGGTTGTGAAGAGCATGTAGCTGTAGCACTTGAAAAAAT
AGGTGCTAGAAATATTGAAGCTAGCTTTCGTCGTGGTGAAGCAGTATTTGAATTATCCGATGATATTGGGGTTGAAATTG
TAAAAAAGGCAATTGATGAAGCAAAATATCAACTAGGAGAAATAGAAGAAGTTTCACCACAAGAAAATGTGGTGTTGGGT
GATGATGGAGATTATGACTTACTTATCATTGGTTCTGGTGGGGCTGCTTTTTCGGCTGCGATTAAAGCAATTGAATACGG
GGCAAAAGTAGGCATGATTGAGCGTGGAACGGTTGGGGGAACATGTGTAAATATTGGTTGTGTGCCATCAAAAACACTTC
TTAGAGCTGGGGAAATCAATCATTTAGCAAAAGTTAACTCATTTACGGGTTTGCAAACTTCAGCTGGAGAAGTGGAATTA
GCACCTCTAATTAAGCAGAAAAATAAATTAGTGAGTGAGCTTAGGAATCAAAAATATGTTGATTTAATTGATGAATATGG
CTTTGATTTAATTGAAGGTGAAGCAAAGTTTGTTAATGAAAATATAGTTGAAGTTAACGGGAAGAAACTTTCAGCAAAGC
GTTTCTTAATTGCAACGGGGGCTTCTCCTTCTTTACCGTCGCTTTCAGGACTTGAAGAAGTGGATTATCTAACAAGTACA
ACACTACTTGAATTAAGAAAGGTGCCAAAGCGATTAACGGTTATCGGTTCAGGATATATCGGAATGGAGCTTGGGCAACT
GTTTCATAATTTAGGTTCAGAAGTAACACTTATGCAAAGAAGTGAGCGACTTTTAAAAGAGTATGACCCAGAGATTTCAG
AAGCAGTAGAAAAAGCGTTAATTGAACAAGGTATAAACCTTGTCAAAGGGGCAACTCTTGAGCGTGTAGAACAAGTCGGA
AAGCTAAAAAAGGTTCATGTAACAATAGATGGTAAGAAAAAAGTTGTGGAATCAGAGCAGTTACTTGTTGCAACAGGAAG
AAAACCAAATACGGATTCTTTAAATTTAAGTGCAGCAGGGGTTGAAGTCGGAAAACGAAAAGAAATCCTGATAAATGATT
ATGCTAGAACAAGTAATGAAAAGGTTTATGCAGCAGGAGATGTAACATTAGGACCTCAATTTGTCTATGTAGCAGCCTAT
GAAGGTGGACTTGTTGCGGATAATGCGATTGGTGGATTAAATAAAAAATTAGATTTATCGGTTGTTCCTGGTGTGATATT
TACAAATCCATCGATTGCAACGGTTGGTTTAACAGAGGAACAAGCAAAAGAAAAAGGCTATGAAGTAAAAACCACTGTAT
TACCTTTAGATGCCGTTCCAAGAGCGATTGTAAATCGTGAAACAACAGGTGTTTTCAAGCTAGTTGCTGACGCGAAAACA
TTAAAAGTCCTTGGGGTTCATATCGTATCTGAAAATGCAGGTGATGTGATTTATGCAGCGACATTAGCCGTTAAATTTGG
TTTAACTGTTGAGGATTTAAAAGAAAGCCTTGCACCATATTTAACAATGGCAGAAGGATTAAAGCTGGCTGCACTTACCT
TTGATAAAGATGTATCGAAATTATCTTGTTGTGCAGGATGA

Protein sequence : 
MNKFKINIQGMTCTGCEEHVAVALEKIGARNIEASFRRGEAVFELSDDIGVEIVKKAIDEAKYQLGEIEEVSPQENVVLG
DDGDYDLLIIGSGGAAFSAAIKAIEYGAKVGMIERGTVGGTCVNIGCVPSKTLLRAGEINHLAKVNSFTGLQTSAGEVEL
APLIKQKNKLVSELRNQKYVDLIDEYGFDLIEGEAKFVNENIVEVNGKKLSAKRFLIATGASPSLPSLSGLEEVDYLTST
TLLELRKVPKRLTVIGSGYIGMELGQLFHNLGSEVTLMQRSERLLKEYDPEISEAVEKALIEQGINLVKGATLERVEQVG
KLKKVHVTIDGKKKVVESEQLLVATGRKPNTDSLNLSAAGVEVGKRKEILINDYARTSNEKVYAAGDVTLGPQFVYVAAY
EGGLVADNAIGGLNKKLDLSVVPGVIFTNPSIATVGLTEEQAKEKGYEVKTTVLPLDAVPRAIVNRETTGVFKLVADAKT
LKVLGVHIVSENAGDVIYAATLAVKFGLTVEDLKESLAPYLTMAEGLKLAALTFDKDVSKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 9e-177 70
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 1e-176 70
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 2e-77 43
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 6e-80 42
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 8e-79 41
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-81 41
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-81 41
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-81 41
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 5e-79 41
merA AFG30120.1 MerA Not tested PAGI-2 Protein 5e-79 41
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 6e-79 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
BpOF4_20564 YP_003429000.1 mercuric reductase BAC0224 Protein 0.0 75
BpOF4_20564 YP_003429000.1 mercuric reductase BAC0651 Protein 6e-177 70
BpOF4_20564 YP_003429000.1 mercuric reductase BAC0650 Protein 2e-77 45
BpOF4_20564 YP_003429000.1 mercuric reductase BAC0653 Protein 8e-80 41