Gene Information

Name : Kfla_5642 (Kfla_5642)
Accession : YP_003383447.1
Strain : Kribbella flavida DSM 17836
Genome accession: NC_013729
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 6072940 - 6074094 bp
Length : 1155 bp
Strand : -
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: afw:Anae109_3845 cystathionine gamma-lyase

DNA sequence :
GTGGAGATTGGACAGCAGTACGGCTTCGAGACGCTCGCGATTCATGCCGGCAACGAGCCCGACCCGACCACCGGAGCGGT
GGTGCCGCCGATCTATGCGACGAGCACCTACAAGCAGGACGGCGTCGGCGGGCTGCGCAACGGCTACGAGTACTCCCGGT
CGGCGAACCCGACCCGGACCGCGCTGGAGGAGTGTCTGGCCGCGATCGAGGGCGGCAAGCGTGGTTTCGCGTTCGCCAGC
GGCCTCGCCGCCGAGGACACGCTGATCCGCTCGCTGTGCGTGCCCGGCGACCACGTGGTGTTCCCCGACGACGCGTACGG
CGGCACGTTCCGGCTGTTCTCCAAGGTGCTCGGTGCCTGGGGCGTCGAGATGTCCCCGGCCGCGGTCACCCACCCGGAGG
CGATCCGGGCCGCGATCCGCCCGGGCAAGACCAAGGTGGTCTGGCTGGAGACGCCGACCAACCCGCTGCTGAACGTCGCC
GACATCGCGATCGTCGCGCAGATCGCGCACGACGCCGGGGCGCTGCTGGTGGTCGACAACACCTTCGCCTCGCCGTACCT
GCAGCAGCCGCTGGAGCTCGGTGCCGACGTGGTGGTGCACTCGACCACGAAGTACATGGGTGGTCACTCCGACGTGGTCG
GCGGTGCGCTGATCGTGCGCGACGCCGAGCTGGCCGACAAGATCGCCTTCCACCAGAACGCGATCGGCGCGGTCGCCGGG
CCGTTCGACTCCTGGCTGGTGCTGCGCGGGATCAAGACGCTCGGGGTCCGGATGGACCGGCACAGCGACAACGCGGAGAA
GGTCGTGGAGTTCCTGCAGCGGCACTCGGCGGTCACCTCGGTGCTGTACCCGGGCGTCGAGGGCCACCCCGGCCACGACA
CCGCCGCCAAGCAGATGAAGCGGTTCGGCGGCATCGTGTCGTTCCGGGTCACCGGTGGCGAGCAGCACGCGCTGGACATC
TGCAACAAGGCCGAGGTCTTCACGCTGGGCGAGTCGCTCGGTGGCGTCGAGTCGCTGATCGAGCACCCGGGCAAGATGAC
GCACGCCTCGGTCGCCGGTACGCCGCTGGAGGTGCCGGCCGACCTGATCCGGCTCAGCGTCGGGATCGAGACGATCGACG
ACCTGCTGCACGACCTCGACCGCGCCCTGGCCTGA

Protein sequence :
MEIGQQYGFETLAIHAGNEPDPTTGAVVPPIYATSTYKQDGVGGLRNGYEYSRSANPTRTALEECLAAIEGGKRGFAFAS
GLAAEDTLIRSLCVPGDHVVFPDDAYGGTFRLFSKVLGAWGVEMSPAAVTHPEAIRAAIRPGKTKVVWLETPTNPLLNVA
DIAIVAQIAHDAGALLVVDNTFASPYLQQPLELGADVVVHSTTKYMGGHSDVVGGALIVRDAELADKIAFHQNAIGAVAG
PFDSWLVLRGIKTLGVRMDRHSDNAEKVVEFLQRHSAVTSVLYPGVEGHPGHDTAAKQMKRFGGIVSFRVTGGEQHALDI
CNKAEVFTLGESLGGVESLIEHPGKMTHASVAGTPLEVPADLIRLSVGIETIDDLLHDLDRALA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-77 48
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-78 48
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 4e-59 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Kfla_5642 YP_003383447.1 cystathionine gamma-synthase BAC0207 Protein 5e-61 42