Gene Information

Name : Kfla_3619 (Kfla_3619)
Accession : YP_003381475.1
Strain : Kribbella flavida DSM 17836
Genome accession: NC_013729
Putative virulence/resistance : Resistance
Product : D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1052
EC number : -
Position : 3892281 - 3893321 bp
Length : 1041 bp
Strand : +
Note : PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: mxa:MXAN_7165 D-lactate dehydrogenase

DNA sequence :
ATGACCTCCAGCGAACCAGCACCAGCGGTCCGCCGCACCCGATCGCTGGCATCCTGGCTCTCCTCGGCCGTACCCGGAAC
CGGCGTCACGGTCTACGGATGCGGGCCGGACGAGGCCGTCCTGTTCCGGCAACTGGCGCCTCGCTTCGGCGTCGCGCCGA
CGATCACCGAGGCGGCGGTGTCGGAGGCCACGGTGGAACTGGCGGCCGGAAACCGGTGCATCAGTGTCGGCCACAAGACA
CCCATCACCCACCGGATCCTGGATGCGCTCAGCCAGGCCGGCGTGACCTACATCTCCACCAGAAGCATCGGCTACAACCA
CCTCGACGTGACGTACGCCGAGAGCGTCGGCATCACCGTCGAGAACGTCGCGTACTCGCCGGACAGCGTGGCCGACTACA
CGCTGATGCTGATGCTGATGGCGGTGCGTCACGCCAAGTCCACCATCCGCCGGGCGGACGCCCACGACTACCGGTTGAAC
GACGTCCGCGGGAAAGAGCTGCGCGACCTGACCGTCGGGGTCGTCGGAACGGGACGCATCGGCGCCGCCGTGGTGGACAG
GCTGCGCGGCTTCGGCTGCCTGGTCCTTGCCCACGACAACTGCCCGGGGGTCGCCGCGGAGTACGTACCTCTCGATGACC
TGCTGCACCGCAGCGACATCGTCACGCTGCACACCCCGCTGACAGCCGAGACCCACCACCTCCTGCATCGGCAGCGGATC
GAGCAGCTGAAGCAAGGCGCGTACGTCGTCAACACCGGACGCGGCGCGCTGCTCGACACCGAGGCGCTGCTGTCGGCCTT
GGAAAGCGGCAGGTTGGGCGGCGCGGCCCTGGACGTGCTCGAAGGCGAAGAAGGAATCTTCTACGCCGACTGCAGCGGCC
GCCGCATCGACCATGACCTGTTGCTGCGGCTGCAGCGCCTGCCCAACGTGCTGATCAGTCCGCACACCGCCTACTACACC
GACCATGCCCTCAGTGACGCCGTGGAGAACTCCCTCGGCAACTGTGTGAAATTCCAGAGCAGAAAGCAGCAGTGGATATG
A

Protein sequence :
MTSSEPAPAVRRTRSLASWLSSAVPGTGVTVYGCGPDEAVLFRQLAPRFGVAPTITEAAVSEATVELAAGNRCISVGHKT
PITHRILDALSQAGVTYISTRSIGYNHLDVTYAESVGITVENVAYSPDSVADYTLMLMLMAVRHAKSTIRRADAHDYRLN
DVRGKELRDLTVGVVGTGRIGAAVVDRLRGFGCLVLAHDNCPGVAAEYVPLDDLLHRSDIVTLHTPLTAETHHLLHRQRI
EQLKQGAYVVNTGRGALLDTEALLSALESGRLGGAALDVLEGEEGIFYADCSGRRIDHDLLLRLQRLPNVLISPHTAYYT
DHALSDAVENSLGNCVKFQSRKQQWI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF2295 NP_815952.1 D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 2e-87 59
vanHB YP_008394258.1 VanH protein, D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 7e-87 58

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein AF155139.2.orf4.gene Protein 8e-95 62
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein NC_005054.2598279.p0 Protein 1e-92 59
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein NC_014475.1.orf2.gen Protein 1e-92 59
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein U35369.1.gene5.p01 Protein 2e-87 59
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein AF310956.2.orf4.gene Protein 1e-87 58
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein FJ349556.1.orf3.gene Protein 2e-91 58
Kfla_3619 YP_003381475.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein AF130997.1.orf3.gene Protein 2e-77 54