Gene Information

Name : pyk (HMPREF0424_0607)
Accession : YP_003373843.1
Strain : Gardnerella vaginalis 409-05
Genome accession: NC_013721
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 665414 - 666853 bp
Length : 1440 bp
Strand : +
Note : identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064

DNA sequence :
ATGCGTAAAGCCAAAATCGTTGATACTATTGGTCCAGCTACCGAATCCTTGGAAGGTATTACCAAGCTTGTTGAAGCCGG
TATGGATGTTGCTCGTTTGAACCGTTCTCACGGCACTCCTGAAGATCATTTGCGCGTTTACAACAACGTTCGTGCAGCTT
CCAAGTCCACTGGCCGCAATGTTGCTGCTCTTGTTGATTTGCAAGGTCCAAAGATTCGCTGCGGTTGGTTCAAGAAGAAC
GCTGAAGGCGAAGATAAGGTTTATTTGGAAGAAGGTCAGGAGTTCATCATCACTACTGATGATGTTGAAGGTGACGAGCA
CCGCACTTCTACAACTTTTAAGGGCTTGCCAGGAGATTGCCACGCAGGCGACCCAATCCTTATCGATGACGGTAAGGTTC
GTCTTGAGGTAACCAAGGTAGAAGGCAACGACGTTCACACTAAGGTTATTGTTGCTGGTCCAGTTTCCAGCCACAAGGGC
ATTAACCTCCCAGGTGTTGCAGTTTCTCTTCCAGCTTTGACTGAAAAGGATGAGGCTGATCTTCGTTGGGCTATTCGCAC
CGGCGCTGACATTATTGCTATGTCCTTCGTGCGTTTCGCTACCGATATTGATCGCGCTCACGAAATCATGGACGAAGAAG
GTCGTCGTATTCCAATCGTCGCCAAGATTGAAAAGCCACAGGCTGTTGAAAACTTGGAAGAGATTGTTAAGACCTTCGAT
GGCATTATGGTTGCTCGTGGTGATATGGCTGTTGAAATGCCTCTCGAAGAGGTTCCACTGGTCACCAAGCGTTGCATCGA
GCTTTCTCGTCGCTATGCAAAGCCAGTTATCGTTGCTACTGAAGTTCTTGGCACAATGGTTAACTCTCCAGTTCCAACTC
GTGCAGAAGCTTCTGACTGCGCTAACGCTGTTCTCGACGGTGCTGACGCAACAATGACTTCTAACGAAACTGCTGTTGGT
AAGTACCCAGATGTTACCGTAAAGACCATGTCCCGTATTTCTCAGTACGCAACTGAGCACGGCTATGATCGCATTCCTGC
TGTTGAGCTTGATATGTCTAGCACCGGTGCTGTTTCTTCTGCAGCTGTTGATTTGGCAGATAAGCTTAATGCTAAGGCTA
TTGTTGCTTACACTCAGACTGGTCGCACAGTTCATCGTATTTCTCGTGAACGTCCAACCGCTCCAATCTTTGGCTTGACT
AACAATGAGCACACTTATCGTTGGTTGGCTTTGAGCTGGGGCACTGAAGGCTTCTTGATTGATGAAGATTACCATGACAT
GAATCGTCACGATTTGATGATCTTCACCGACAAGGTTCTTCGCGAAGCCGGTAAGGTTTCCGATGGTGATCAGATTGTTA
TCTTGAGCACTGCTCAGGGTGAACGCCAGGCTGGTCGTACTGACTCCATCTACGTTCACACCGTTGGTGCTTGCGACTAA

Protein sequence :
MRKAKIVDTIGPATESLEGITKLVEAGMDVARLNRSHGTPEDHLRVYNNVRAASKSTGRNVAALVDLQGPKIRCGWFKKN
AEGEDKVYLEEGQEFIITTDDVEGDEHRTSTTFKGLPGDCHAGDPILIDDGKVRLEVTKVEGNDVHTKVIVAGPVSSHKG
INLPGVAVSLPALTEKDEADLRWAIRTGADIIAMSFVRFATDIDRAHEIMDEEGRRIPIVAKIEKPQAVENLEEIVKTFD
GIMVARGDMAVEMPLEEVPLVTKRCIELSRRYAKPVIVATEVLGTMVNSPVPTRAEASDCANAVLDGADATMTSNETAVG
KYPDVTVKTMSRISQYATEHGYDRIPAVELDMSSTGAVSSAAVDLADKLNAKAIVAYTQTGRTVHRISRERPTAPIFGLT
NNEHTYRWLALSWGTEGFLIDEDYHDMNRHDLMIFTDKVLREAGKVSDGDQIVILSTAQGERQAGRTDSIYVHTVGACD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-64 43
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-64 43
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-64 43
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-64 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_003373843.1 pyruvate kinase VFG0479 Protein 4e-65 43