Gene Information

Name : HMPREF0424_0103 (HMPREF0424_0103)
Accession : YP_003373370.1
Strain : Gardnerella vaginalis 409-05
Genome accession: NC_013721
Putative virulence/resistance : Virulence
Product : thiol-activated cytolysin
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 121784 - 123334 bp
Length : 1551 bp
Strand : -
Note : identified by match to protein family HMM PF01289

DNA sequence :
ATGAAGAGCACAAAGTTCTACCGTAATGCAGCAATGTTGTTGCTCGCGGGCGCGACTATTATTCCACAATGCTTAGCAGT
TCCAGCAATGGCAGATTCTTCTGCAAAGCCTTCTGCACCAGCTGCATCTTGTGCAGCTAGCAAGGACTCGCTGAACAACT
ACTTGTGGGATTTGCATTACGATAAAACGAATATTCTCGCACGTCACGGCGAAACAATTAACAATAAATTCTCTAGCGAT
AGCTTCAACAATAACGGTGAATTCGTTGTTGTTGAGCACCAGAAGAAGAACATCACAAATACAACATCAAACTTGTCGGT
AACTTCGGCCAACAATGATCGCGTATATCCGGGTGCATTATTCCGCGCTGACCAGAATTTGATGGATAACATGCCAAGCT
TGATTTCAGCAAATCGTGCTCCATTAACTTTGAGTATTGATTTGCCAGGCTTCCATGGCGGCGAGAGTGCTGTAACCGTG
CAACATCCAACCAAGAGCTCCGTTACTTCAGCAGTTAACGGCTTAGTTTCTAAGTGGAATGCACAATATGCAGCAAGCCA
TCATGTGGCAGCTCGTATGCAGTATGATTCCGCAAGCGCACAGAGCATGAACCAGCTCAAAGCTAAGTTTGGTGCTGATT
TTGCAAAGATTGGCGTACCGCTGAAGATTGATTTCGATGCAGTACACAAGGGTGAGAAGCAGACTCAAATTGTGAACTTC
AAGCAAACTTACTACACAGTAAGCGTTGACGCTCCAGATAGCCCAGCAGATTTCTTTGCTCCATGCACTACGCCAGAAAG
CTTGAAGAACCGTGGCGTTGACAGCAAACGCCCACCAGTTTACGTATCAAACGTAGCTTATGGTCGCTCAATGTACGTAA
AGTTCGATACCACCAGCAAGAGCACTGATTTCCAGGCTGCAGTAGAAGCAGCAATTAAGGGCGTAGACATCAAGCCAAAC
ACCGAATTCCATCGCATTCTCCAGAATACCTCTGTTACTGCAGTGATTCTCGGCGGCAGCGCTAACGGTGCAGCAAAGGT
TATTACCGGCAATATCGATACGCTAAAGGCTTTGATTCAGGAAGGTGCAAATTTGAGCACCTCTAGCCCAGCTGTTCCAA
TCGCTTACACTACTTCCTTCGTAAAAGATAACGAAGTAGCAACTCTCCAGAGCAACAGCGATTATGTTGAGACTAAGGTT
TCTGCTTACCGTGACGGTTATTTGACCTTGGATCATCGTGGGGCTTATGTAGCTCGCTACTACGTCTACTGGGATGAGTA
CGGCACTGATATCGACGGAACTCCATACGTACGTTCTCGCGCTTGGGAAGGAAACGGCAAGTATCGTACCGCTCACTTCA
GCACAACGATTCAGTTCAAGGGCAATGTGCGCAATCTTCGCATTAAGTTGGAAGAAAAGACCGGCTTAGTATGGGAACCA
TGGCGCACAGTGTACAACCGTACTGATTTGCCGTTGGTTCGCCAGCGCACAATCAAGAACTGGGGTACAACTTTATGGCC
TCGCGTCGCTGAAACTGTAAAGAATGACTGA

Protein sequence :
MKSTKFYRNAAMLLLAGATIIPQCLAVPAMADSSAKPSAPAASCAASKDSLNNYLWDLHYDKTNILARHGETINNKFSSD
SFNNNGEFVVVEHQKKNITNTTSNLSVTSANNDRVYPGALFRADQNLMDNMPSLISANRAPLTLSIDLPGFHGGESAVTV
QHPTKSSVTSAVNGLVSKWNAQYAASHHVAARMQYDSASAQSMNQLKAKFGADFAKIGVPLKIDFDAVHKGEKQTQIVNF
KQTYYTVSVDAPDSPADFFAPCTTPESLKNRGVDSKRPPVYVSNVAYGRSMYVKFDTTSKSTDFQAAVEAAIKGVDIKPN
TEFHRILQNTSVTAVILGGSANGAAKVITGNIDTLKALIQEGANLSTSSPAVPIAYTTSFVKDNEVATLQSNSDYVETKV
SAYRDGYLTLDHRGAYVARYYVYWDEYGTDIDGTPYVRSRAWEGNGKYRTAHFSTTIQFKGNVRNLRIKLEEKTGLVWEP
WRTVYNRTDLPLVRQRTIKNWGTTLWPRVAETVKND

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hly AAA69525.1 listeriolysin O Virulence LIPI-1 Protein 2e-95 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HMPREF0424_0103 YP_003373370.1 thiol-activated cytolysin VFG1363 Protein 5e-126 54
HMPREF0424_0103 YP_003373370.1 thiol-activated cytolysin VFG2275 Protein 3e-88 42
HMPREF0424_0103 YP_003373370.1 thiol-activated cytolysin VFG0074 Protein 2e-95 42