Gene Information

Name : cadA (MCP_1370)
Accession : YP_003356425.1
Strain : Methanocella paludicola SANAE
Genome accession: NC_013665
Putative virulence/resistance : Resistance
Product : cadmium-transporting ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 1367331 - 1369784 bp
Length : 2454 bp
Strand : -
Note : -

DNA sequence :
ATGACGGAACACGAAAAAGAAAAATGCAACTGCGGCACGTGTCACGAGGAAGAGGAAAGCCACGAGGAGAAGGGGACGTG
CAGCTGCGGCACGTGCCATGACGAAGTCGAATGCCACGAAGATCACGAGGAGACCGAGTGTCAGGTCTGCCGCATCGAGC
CCGAAGGGAAGGGTCCGCTCAGGGAGACAGGATTTAAGATCGACAACATGGACTGTGCAGACTGTGCCAAAAAGCTGGAG
GAGCGCATAGCTAAGGTGCATGGCGTCACCTCGGTGAAGTTCAACTTCGGGACGGCGACCCTGAATATCAAGCATACGGG
AGCCGCCTCGGACTTGCTTGATGTCGTCGAGCAGTCCGGTTACCATGTGGCCGCGGATACGTTTAAGATCACACAGTTCG
ACGTGCAGGAGCTGGACTGCATCGACTGCGCGAAGAAGTTCGAGAAGGCCATCGCCATGACGCCCGGGGTCATCCGGGCT
TCGCTAAATTTTGCCGTAGGCAAGCTAATCGTAGAGCACACATGTCCTGTTGATGATATCCTTGCGGCTGCCCGCGACAT
TGGGTATACCATCAAGGTATCCGGCACAAAGGAAAAGGGATCATTTTTTACCAGGCACAGGCCCGTTTTAATTACTGTAG
TATCAGGACTCCTCACAGTTACAGGGTTCACCCTGAGCCACCTGAACGTGCCCCCGTATATTCCGATACTGCTGTATTTC
ATGGCCATCGTCGTAGGCGGATCCCACATCGCGAAGAGCGCCATATACTCGCTCAAGACCATGACGGCGGACATGAACCT
CCTGATGACCATCGCGATCATCGGCGCAATGGCCATAGGCCAGTGGGAGGAAGGCGCCACAGTGGTCGTACTATTCGCTC
TGGGCAACGCCCTACAGTCCTATACACTTGATAAGACGCGCAATTCCATTAAAGAGCTGATCTCGATCACGCCGAACGAT
GCCGCGGTAATAAGGAACGGCAGCGAGGTCAGGCTTAATACCGCTTTAATAAATGTCGGCGACATGATCGTGGTGAAGCC
GGGAGAAAAAATACCCATGGACGGCGAGGTGATCAGCGGCTTGTCCTACGTAAACCAGGCGCCAATTACCGGCGAGTCCA
TGTCCGTCGAAAAGGAGCCTGGCAGCGTCGTATACGCGGGCACCATCAACGAGAACGGTGCCCTTGAGATAAAAGTCACC
CGGCTTGCAAAGGACAACACGCTTAGCAAGATCATCCACATGGTCGAGGAAGCGCAGGTACAGCGGGCGCCGACTCAGGT
GTTCCTCGATAAATTCACAAAATATTACACGCCGGCCGTCATCCTTCTGGCAGCGGGCGTCGCCATCATACCCACGCTGA
TGGGCCAGCCCTTCTATACCTGGCTCTACCGGGGCCTCGTGCTCCTGGTCATCTCGTGCCCCTGCGCGCTCGTCATTTCC
ACGCCCGTCTCGATCGTCGCGGCCATCGGCAGCGCCTCGAGGAACGGCGTACTCATCAAGGGCGGCAGCTATCTGGAAGA
GATCGGGCGCGCCCGGGCCATCGCGTTCGATAAGACGGGCACGCTGACCAAAGGCAAGACCGCCGTATCCGAGGTCGTTA
ACTTTGACTCGCTCGATACGGCGCAGATCATGAATATCGCCGCCTCGCTCGAATCGAAGTCCGGGCACCCGCTGGCGGCC
GCCATCATCCGGGCGAACCACGGGCAGACGCCCATGCCGGTCGAAAATTTCCAGTCCGTCACGGGTAAGGGAGTTACGGG
CACCGTCGACGGTGTTGATTACACACTGGGAAATCTAAAGATGTTCGAGGCCGTGAACGAGAATGTTCAACAGACTGTAG
CCCATCTCCAGGAAGCCGGGATGACGCCGGTCATCCTCGGCAAAGACCACGCGATCCTGGCCGTTATCGCCATTTCCGAC
GAGGTCCGGCCCGAGAGCCGGGAGCTGGTTAAGGACCTGCACAAGTCCGGCCTGAAGGAGGTCGTCATGCTCACCGGCGA
CAACAACCGCATGGCAAAGGCCATCGCCTCCGACATCGGCCTGGACGGCTACTTCGGGGAGCTCTTACCGGAGGAGAAGG
CGAACATCGTGAAGGGCATACGTAAAGCCCACGGCAACGTGATCATGGTCGGCGACGGCGTTAACGACGCCCCGGCCCTT
GCCGCATCCAATGTGGGCATCGCCATGGGCGCCACTGGCTCGGACACGGCGCTTGAAACGGCCGATATCGCCCTCATGGC
CAATGACCTTACAAAGGTCGACTACACCATTCGCCTGGGACGCCACACCCTGTCGATCATCAAGCAGAACGTCATCTTCG
CCATTGCCATCAAGGCGGTATTCATAGGGCTGGCCGTCTTCGGCATGGCGAACCTGTGGATGGCCGTTTTCGCCGATATG
GGCGCCTCGCTCATCGTCATCCTTAACGGTATGCGCCTCATCAGGACACATTGA

Protein sequence :
MTEHEKEKCNCGTCHEEEESHEEKGTCSCGTCHDEVECHEDHEETECQVCRIEPEGKGPLRETGFKIDNMDCADCAKKLE
ERIAKVHGVTSVKFNFGTATLNIKHTGAASDLLDVVEQSGYHVAADTFKITQFDVQELDCIDCAKKFEKAIAMTPGVIRA
SLNFAVGKLIVEHTCPVDDILAAARDIGYTIKVSGTKEKGSFFTRHRPVLITVVSGLLTVTGFTLSHLNVPPYIPILLYF
MAIVVGGSHIAKSAIYSLKTMTADMNLLMTIAIIGAMAIGQWEEGATVVVLFALGNALQSYTLDKTRNSIKELISITPND
AAVIRNGSEVRLNTALINVGDMIVVKPGEKIPMDGEVISGLSYVNQAPITGESMSVEKEPGSVVYAGTINENGALEIKVT
RLAKDNTLSKIIHMVEEAQVQRAPTQVFLDKFTKYYTPAVILLAAGVAIIPTLMGQPFYTWLYRGLVLLVISCPCALVIS
TPVSIVAAIGSASRNGVLIKGGSYLEEIGRARAIAFDKTGTLTKGKTAVSEVVNFDSLDTAQIMNIAASLESKSGHPLAA
AIIRANHGQTPMPVENFQSVTGKGVTGTVDGVDYTLGNLKMFEAVNENVQQTVAHLQEAGMTPVILGKDHAILAVIAISD
EVRPESRELVKDLHKSGLKEVVMLTGDNNRMAKAIASDIGLDGYFGELLPEEKANIVKGIRKAHGNVIMVGDGVNDAPAL
AASNVGIAMGATGSDTALETADIALMANDLTKVDYTIRLGRHTLSIIKQNVIFAIAIKAVFIGLAVFGMANLWMAVFADM
GASLIVILNGMRLIRTH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-140 44
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 7e-140 43
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 6e-140 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_003356425.1 cadmium-transporting ATPase BAC0298 Protein 4e-115 42
cadA YP_003356425.1 cadmium-transporting ATPase BAC0100 Protein 6e-67 41