Gene Information

Name : Tcur_3970 (Tcur_3970)
Accession : YP_003301537.1
Strain : Thermomonospora curvata DSM 43183
Genome accession: NC_013510
Putative virulence/resistance : Unknown
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 4525141 - 4528482 bp
Length : 3342 bp
Strand : +
Note : KEGG: afr:AFE_0480 lysyl-tRNA synthetase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); protein of unknown function DUF472; protein of unknown function DUF471; protein of unknown function DUF470; nucleic acid binding OB-fold

DNA sequence :
ATGACGGCTGACAGCAAGGTCCCGGCCGGCACCGCCGGCCACGGGCTGCGTGACGGCTGGCAGCGCCTCACCAAAGCGGC
CCCCGACGTCTTCTTCTGGTACACCCGCCTGTCGGGCGTGCTGTCGATCCTGGCGTTCGTCTCCTCGGACCTGATCCAGC
GGCTGGGCGGCATCTGGGCGCTGCAGTGGATCTACTACCTGGGCTTCACCGCCAGCCTGCCGTACGGGGTGCTGCTGATC
CTGCTGTCGATGGGCGTGCGGCGGCGCAAGAAGGCCGCCTGGCGGATCCTGATGCTGCTGTTCGGCGGCTACTTCGCCAT
CGCGCTGCTGGTGGTCGGCTCCCTGGCGGCCGATCCGGACCGGTCGGTGGCGGCCGGCGAGCTGGTCACGGTGGTCGCCT
ACGCGGCGGTGCTGACGCTGCTGGCGGCGGCGCGTCCGGAGTTCAACGCGCTGCCCGACCGGGCCAACCGGCGGCTGGCG
CTGGCGGTGTTCTCCGGGCTGCTGGTGGTCAGCGGGCTGCTGGGCACCGGGCTGGTCACGTTGATGAACCGCGACCCCGA
CGGGCGCTTCCTGACCGACGCGCTGTATGTGGTGCTGCAGACCGTCGGCGGGCCGGGGGTGACCGGCGAGCCCATCAACG
TGGACGTGCCGACCCGGGTCAACCTGCTGCTGGGGGTGCTGGGCACCGGCCTGCTGATCATCACGTTCTGGGCGCTGTTC
CGCCCGGGCCATCGCGACGCGGTGCTCAGCCCCGCCGAGGAGCTGACCGCCCGCCGGCTGCTGGCCGAGTACGGCGAGCA
GGACTCGTTGGGCTACTTCGCGCTGCGCCGCGACAAGAACGTCATCGTCGCCCCCAACGGCAAGGCCGCCATCTCCTACC
GCGTCGAGGGGGCGGTCTCGCTGGCCAGCGGCGACCCGCTGGGCGACCCGGAGTCCTGGGACCAGGCCATCGAGCTGTGG
CTGGCCGAGTGCCGCGCGCACGCCTGGATCCCCGGGGTGGTCAGCGCCGGGGAGCGCGCCGCGCACGTCTACCGGCGGCA
CGGCTTCGACGCGCTGGAGCTGGGCGATGAGGCCATCTTGGAGCTGACCGACTTCACCTTGGACGGCCGGGAGATGCGCC
AGGTCCGCCAGGCGGTGCGGCGGGTGGAGCGGGCCGGCTACACGGTGCGGATCCGCCGGCACGCCCAGATCCCGCCCGAG
GAGATGGCGCAGCTGATCGCCAGCGCCGACCGGTGGCGGGAGGGGGCCATCGAGCGCGGGTTCTCCATGGCGCTGGGCCG
CCTCGGCGACCCCACCGACGGCCGCTGCCTGATGGTCGAGGCGTTCGACGCCCAGGGCCGGCTGCGCGGCCTGCTGAGCT
TCGTGCCCTGGGGCCGGCACGGGCTGTCGCTGGACCTGATGCGCCGCGACCGCACCGCCGAGAACGGCCTGAACGAGTTC
ATGATCGCCAAGGTGGCGGAGCAGGCGGCGCTGATCGGCGCGCAGAAGATGTCGCTGAACTTCGCGATGCTGCGCTCGGC
GTTCGAGCGCGGCTCCCAGCTGGGCGCCGGGCCGGTGGCCCGGGCCTGGCACCGGTTCCTGTCGCTGGCCTCCAAGTTCT
GGCAGCTGGAGTCGCTGTACCTGGCCAACGCCAAGTACAACCCCACCTGGGCGCCCCGGTTCGTCTGCTACCAGCAGTCC
CGGGACCTGGTGCGGCTGGGGCTGGCGTTCGCCCGGGCCGAGGGGTTCCTGCCCACCCTGAACCGGCCCCGCCTGGAGCG
CGCCGCCCGGCTCACCCCCTCCCCCGAGCTGGTGCGGCGGATCAAGCGGATCGAGGAGGAGGCCGAGGCCGCCCGCGCCC
CGCAGCGGCGGCTGTCGGAGCAGGAGCGGGTGCGGCACGCCAAGCTGGAGCACATCCGCGCCGCCGGGATGGACCCCTAC
CCGCTGGGGTTCGACCGCACCGATTTCGCCGCCGACATCCGCGCCCGCTTCGGCGGCCTGCCCCCCGACGCCCGCACCGG
CGAGCAGGTGCGCATCGCCGGGCGGGTGATGCTGGCCCGTGAGCACGGCCGGCTGGTGTTCGTCACGCTGCGCGATGAGA
CCGGCGACATCCAGGTGATGCTGTCGGCCGACCGGCTGGAGCCCGACGGGCCGGACGGCGCGCCGGTCCCCGGCTCGCTG
CGGGCCTGGAAGCGCCTGATCGACCTGGGCGACCAGGTCGGCATCGCGGGCGAGGTGGTCACCTCCAAGCGCGGGGAGCT
GTCGGTGCTGGCCACGAGCTGGACGCTGACGGCCAAATGCCTGCGCCCGCTGCCCAACAAGCGCAGCGGCCTGGCCGACC
CGGAGGCGCGGGTGCGGCAGCGGTATGTGGAGTTCATCGTCAACGACGAGGCCCGCCGGATGCTGCGGATGCGCGGCGAT
GCGGTGGCGGCGATCCGCGACCGGCTGCGCGAGCTGGGCTACCTGGAGGTGGAGACGCCCATGCTGCAGCCCATCCACGG
CGGCGCCGCGGCCCGGCCGTTCACCACCCGCATCAACGCCTACAACATGCAGCTGTACCTGCGGATCGCCCCCGAGCTGT
ACCTCAAGCGGCTGCTGGTCGGCGGGGTCGGCAAGGTCTTCGAGATCAACCGCAACTTCCGCAACGAGGGCGTCTCCCCC
AAGCACAATCCCGAGTTCACGATGCTGGAGGCCTACGAGCCCTACGGCGACTACGACACCATGGCCGCCCTGACCCGGGA
TCTGGTGCTGCGGGCCGCCCGCGCGGCGCTGGGCACCACGGTGGTGGTGCGCGACGGCGCCGAATGCGACCTGGCCGAGC
CGTGGCGCCAGATCACCGTGTACGAGTCGGTCTCCCGGGCCCTCGGCGAGGAGATCACCCCCGACACCCCCGCGTCCCTG
GTCGGCAAGTACGCCGAGCGGGCGGGCCTGGAGTTCGACGCCGGCTGGGGGCAGGGCAAGCTGGTGCAGGAGCTGTTCGA
GGCGCTGGTGGAGCCCGGGATCAAGGCCCCCACCTTCGTCCGCGACTACCCCGCCGAGACCTCCCCGCTGACCCGCCCGC
ACCGCGCCGACCCCCGGCTGGCCGAAAAGTGGGACCTGATCGTCTTCGGGCTGGAGCTGGGCACCGCCTACAGCGAGCTG
ATCGACCCGATCCTGCAGCGGCAGCGGCTCACCGAGCAGTCGCTGCTGGCCGCCGGGGGCGACCCGGAGGCGATGGAGCT
GGATGAGGACTTCCTGCGCGCCCTGGAGTACGCCATGCCGCCGGCCGGCGGGATGGGCATGGGCATCGACCGGCTGCTGA
TCACCCTGACCGGCAAGAGCATCCGCGAGACCATCCCCTTCCCGCTGGCGCGTCCCCGCTGA

Protein sequence :
MTADSKVPAGTAGHGLRDGWQRLTKAAPDVFFWYTRLSGVLSILAFVSSDLIQRLGGIWALQWIYYLGFTASLPYGVLLI
LLSMGVRRRKKAAWRILMLLFGGYFAIALLVVGSLAADPDRSVAAGELVTVVAYAAVLTLLAAARPEFNALPDRANRRLA
LAVFSGLLVVSGLLGTGLVTLMNRDPDGRFLTDALYVVLQTVGGPGVTGEPINVDVPTRVNLLLGVLGTGLLIITFWALF
RPGHRDAVLSPAEELTARRLLAEYGEQDSLGYFALRRDKNVIVAPNGKAAISYRVEGAVSLASGDPLGDPESWDQAIELW
LAECRAHAWIPGVVSAGERAAHVYRRHGFDALELGDEAILELTDFTLDGREMRQVRQAVRRVERAGYTVRIRRHAQIPPE
EMAQLIASADRWREGAIERGFSMALGRLGDPTDGRCLMVEAFDAQGRLRGLLSFVPWGRHGLSLDLMRRDRTAENGLNEF
MIAKVAEQAALIGAQKMSLNFAMLRSAFERGSQLGAGPVARAWHRFLSLASKFWQLESLYLANAKYNPTWAPRFVCYQQS
RDLVRLGLAFARAEGFLPTLNRPRLERAARLTPSPELVRRIKRIEEEAEAARAPQRRLSEQERVRHAKLEHIRAAGMDPY
PLGFDRTDFAADIRARFGGLPPDARTGEQVRIAGRVMLAREHGRLVFVTLRDETGDIQVMLSADRLEPDGPDGAPVPGSL
RAWKRLIDLGDQVGIAGEVVTSKRGELSVLATSWTLTAKCLRPLPNKRSGLADPEARVRQRYVEFIVNDEARRMLRMRGD
AVAAIRDRLRELGYLEVETPMLQPIHGGAAARPFTTRINAYNMQLYLRIAPELYLKRLLVGGVGKVFEINRNFRNEGVSP
KHNPEFTMLEAYEPYGDYDTMAALTRDLVLRAARAALGTTVVVRDGAECDLAEPWRQITVYESVSRALGEEITPDTPASL
VGKYAERAGLEFDAGWGQGKLVQELFEALVEPGIKAPTFVRDYPAETSPLTRPHRADPRLAEKWDLIVFGLELGTAYSEL
IDPILQRQRLTEQSLLAAGGDPEAMELDEDFLRALEYAMPPAGGMGMGIDRLLITLTGKSIRETIPFPLARPR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 3e-156 44
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 3e-156 44
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 3e-156 44
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 8e-156 44