Gene Information

Name : Tcur_3821 (Tcur_3821)
Accession : YP_003301390.1
Strain : Thermomonospora curvata DSM 43183
Genome accession: NC_013510
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 4370952 - 4372178 bp
Length : 1227 bp
Strand : +
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: aav:Aave_2997 O-acetylhomoserine aminocarboxypropyltransferase

DNA sequence :
ATGGACGACCTTCACCGCGACCTTCACCCGCGCACCCGCGCGGCGCATCCGCCCCTGATCCGGCCGGTCGGCAGCCTGCC
GCTGTCCACCCCCATCTACCAGGGGCATTTGTTCTCCTTCGAGGACGCCGAGGCGATGGCGGCGGCCTTCGAGGGGCCGG
CCCGGGCCGATGAGGACGGCCATCGCGCCTTCTACTACAGCCGGATGGGCAACCCGACCGTCCGCATGTTCGAGGAGGCC
GTCAACGACCTGGAGGGCGGCGCCGGGGCGCTGGCCACCGGCTCGGGCATGGGGGCGGTGAACGCCGTGCTGATGTCGCT
GCTGCGCTCGGGCGACCATGTGATCGCCCAGCGGTCGCTGTACGGGGGCACCTACACGCTGCTGCGCGACCTGGCCGAAC
GGTGGGGCGTGGAGGTCACCCACGTCTCCGGGGACGACCTGCGGCAGGTGCGCGCCGCGCTGCGTCCGCGCACCCGGCTG
CTCTACCTGGAGACGATCACCAACCCCACCACCGAGGTGGTGGACCTGCCCGCGCTGGCCGCACTCGCCCGGGAGGCGGG
GGTGCTGACCGCGGTGGACAACACCTTCGCCACCCCGGTGCTGTGCCGGCCCCTGGAACACGGCATCGACATCGTGATCC
ACTCGGCCACCAAGTACCTGGGCGGGCACTCGGACGTGCTGGCCGGGGTGGTGGTCTGCGCCGACGCGGACCTTTACCGC
CGGATCTGGCACCACTCCCTGGAGCTGGGCGCCGGCATCGACCCGATGACCGCCTGGCTGTCGGTGCGGGGAATGGCCAC
GCTCCCGCTGCGGATGGCCCAGCACTGCCACAACGCGCTCGGCCTGGCCCGGCGCCTGGCCGGGCATCCGGCGGTGGAGC
GGGTGCACTACCCCGGCCTGGAGTCGCACCCCCACCACCGGGTCGCCCGGCGGCTGCTGGACGGCGGGTTCGGCGGAGTG
CTGTCGATCGACCTGGCCGGCGGGCGGGAGGCCGGGCGGGTGTTCGCCGAGAGCCTGCGCCTGGTGCGCATGGCCCCCTC
GCTGGGCGGGACCAAGACGCTGGTGCTGCATCCGGCCAGCACCTCGCATCGGGGGCTGGACGAGCGGGCGCTGGCCGAGG
CCGGGATCGGCGCCGGCACCGTCCGGCTGGCCGTGGGCATCGAGGACCTGGACGATCTGTGGGACGACATCGAGCAGGCT
CTGGCCAAGGCGAGCCGGACGGGCTGA

Protein sequence :
MDDLHRDLHPRTRAAHPPLIRPVGSLPLSTPIYQGHLFSFEDAEAMAAAFEGPARADEDGHRAFYYSRMGNPTVRMFEEA
VNDLEGGAGALATGSGMGAVNAVLMSLLRSGDHVIAQRSLYGGTYTLLRDLAERWGVEVTHVSGDDLRQVRAALRPRTRL
LYLETITNPTTEVVDLPALAALAREAGVLTAVDNTFATPVLCRPLEHGIDIVIHSATKYLGGHSDVLAGVVVCADADLYR
RIWHHSLELGAGIDPMTAWLSVRGMATLPLRMAQHCHNALGLARRLAGHPAVERVHYPGLESHPHHRVARRLLDGGFGGV
LSIDLAGGREAGRVFAESLRLVRMAPSLGGTKTLVLHPASTSHRGLDERALAEAGIGAGTVRLAVGIEDLDDLWDDIEQA
LAKASRTG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-52 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tcur_3821 YP_003301390.1 cystathionine gamma-synthase BAC0207 Protein 3e-57 44