Gene Information

Name : Tcur_3204 (Tcur_3204)
Accession : YP_003300783.1
Strain : Thermomonospora curvata DSM 43183
Genome accession: NC_013510
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3705465 - 3707189 bp
Length : 1725 bp
Strand : +
Note : KEGG: met:M446_2211 urease, alpha subunit; TIGRFAM: urease, alpha subunit; PFAM: amidohydrolase; Urease alpha-subunit domain protein; Amidohydrolase 3

DNA sequence :
ATGACTGAACTGTCGCGCGCCCGCTATGCGGCGCTGTTCGGCCCGACCACGGGCGACCGCATCCGCCTGGCCGACACCAA
CCTGTTCATCGAGGTCACCGAGGACCGTTCCATGGGAGCGGCCGGGGCCGGCGATGAGGCGGTGTTCGGCGGCGGCAAGG
TGATCCGCGAATCGATGGGCCAGGCCCGCACCACCCGCGCCGAGGGCGCCGTGGACCTGGTGATCACCGGCGCGGTGGTG
CTGGACTACTGGGGGATCGTCAAGGCGGACGTGGGCGTCCGCGACGGACGGATCGTGGCGCTGGGCAAGGCCGGCAACCC
CGACACCATGGACGGGGTGCACCCGGACCTGGTGATCGGGCCGTCCACCGAGGTGCTGGCCGGCAACGGCAAGATCCTGA
CCGCCGGGGCGATCGACTCCCACGTGCACCTGATCTGCCCGCAGCTGGTGGAAGAGGCGCTGGGCGCCGGGGTGACCACG
CTGCTGGGCGGCGGCACCGGCCCGGCCGAGGGCACCAAGGCCACCACGGTGACCGGCGCCTGGTACCTGCACCGGATGCT
GGAGGCGCTGGATGTCTGGCCGGTCAACGTGGCGCTGCTGGGCAAGGGCAACACCGTCTCCTCCGAGGCGCTGTGGGAGC
AGCTGCGCGCCGGGGCCTGCGGGTTCAAGCTGCACGAGGACTGGGGGTCCACCCCGGCGGCGATCGACGCCTGCCTGAAG
GTCGCCGACGCCTCCGGCGTGCAGGTGGCCCTGCACAGCGACACCCTGAATGAGGCCGGGTACGTGGAGTCCACCCTGGA
GGCGATCGCCGGCCGGTCGATCCACGCCTACCACACCGAGGGCGCCGGCGGCGGGCACGCCCCCGACATCATCACCGTCG
CCGCGCACCCCAACGTGCTGCCGTCCTCGACCAACCCGACCCGCCCGCACACCGTCAACACCCTGGACGAGCACCTGGAC
ATGCTGATGGTGTGCCACCACCTCAACCCGGCGGTGCCCGAGGACCTGGCGTTCGCCGAGTCCCGGATCCGCCCCACCAC
CATGGCGGCCGAGGACATCCTGCACGACCTGGGCGCCATCTCGATGATCGGCTCGGACTCCCAGGCGATGGGCCGGATCG
GGGAGACCGTCATCCGCACCTGGCAGACCGCGCACGTGATGAAGGAGCGCCGCGGCTCCCTGCCGGGCGACGGCGCCGAG
CCCGCCGACAACCTGCGGGCCCGCCGCTATGTGGCCAAGTACACCATCAACCCGGCCATCGCCCACGGCCTGGACGACCT
GGTCGGGTCGGTGGAGCCGGGCAAGCTGGCCGACCTGGTGCTGTGGGAGCCGGCGTTCTTCGGGGTGCGCCCGTCGGTGG
TGCTCAAGGGCGGGGTGATCGCCTGGGCGGCGATGGGCGACGCCAACGCCTCCATCCCCACCCCGCAGCCGGTGCTGCCC
CGTCCGATGTTCGGCGCCGCGCCCGCGGCGGCCGCCGCCACCTCGGTGCACTTCGTCGCCCCGGCGGCGATCGAGGACGG
CCTGGCCGGCAAGATCGCGGTGAACCGCCCGCTGGTGCCGGTCAAGAACACCCGCCGCCTGGGCAAGGCCGACCTGCCGC
TCAACGACGCGCTGCCGGCCATCGAGGTGGACCCGGACACCTTCACCGTCACCATCGACGGCGAGGAGGTCGAGCCCGCC
CCGGCCGCCGAGCTGCCGATGGCCCAGCGCTACTTCCTGTTCTGA

Protein sequence :
MTELSRARYAALFGPTTGDRIRLADTNLFIEVTEDRSMGAAGAGDEAVFGGGKVIRESMGQARTTRAEGAVDLVITGAVV
LDYWGIVKADVGVRDGRIVALGKAGNPDTMDGVHPDLVIGPSTEVLAGNGKILTAGAIDSHVHLICPQLVEEALGAGVTT
LLGGGTGPAEGTKATTVTGAWYLHRMLEALDVWPVNVALLGKGNTVSSEALWEQLRAGACGFKLHEDWGSTPAAIDACLK
VADASGVQVALHSDTLNEAGYVESTLEAIAGRSIHAYHTEGAGGGHAPDIITVAAHPNVLPSSTNPTRPHTVNTLDEHLD
MLMVCHHLNPAVPEDLAFAESRIRPTTMAAEDILHDLGAISMIGSDSQAMGRIGETVIRTWQTAHVMKERRGSLPGDGAE
PADNLRARRYVAKYTINPAIAHGLDDLVGSVEPGKLADLVLWEPAFFGVRPSVVLKGGVIAWAAMGDANASIPTPQPVLP
RPMFGAAPAAAAATSVHFVAPAAIEDGLAGKIAVNRPLVPVKNTRRLGKADLPLNDALPAIEVDPDTFTVTIDGEEVEPA
PAAELPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 1e-148 61
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 1e-148 61
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-144 59
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-145 59
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 4e-145 59
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-145 59

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tcur_3204 YP_003300783.1 urease subunit alpha VFG0270 Protein 3e-130 55