Gene Information

Name : Tcur_2966 (Tcur_2966)
Accession : YP_003300546.1
Strain : Thermomonospora curvata DSM 43183
Genome accession: NC_013510
Putative virulence/resistance : Virulence
Product : ATPase AAA-2 domain-containing protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 3446725 - 3449253 bp
Length : 2529 bp
Strand : -
Note : PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Torsin; UvrB/UvrC protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; KEGG: mxa:MXAN_4832 ATP-dependent Clp protease, ATP- binding

DNA sequence :
ATGGGCGGGGACTGGCAGGAACAGGAGGGCAAGGACCCCTTCGAGGAACTGCTCGCACGGTTCTTCGGCGCGGCCGGCGT
GCACCGGGCGGTGGAACGCGTCAACCTCGCCCGGCTGATGAGCGAGCCGGGCCGCGACCTCATCCGGGACGCGGCCGCCC
GGGCGGCCGAGTGGGGCAGCTCGGATCTGGACACCGACCATCTGCTGTGGGCGGTGACCCGCCAGGAGGCCACCCGGCAC
CTGCTCAGCCGGGCCGGCACCGACCCGGAGGAGCTGGCCGTCCGGGTGGAGGGGCACATCGAACGCGGCCCGGCCCGCGA
CACCCCGCCGATGATGACGCCCTCGGCCAAGCGGGCGCTGCTGGACGCCTTCCAGATCTCCCGTGCCGTCGGCTCGTCCT
ACATCGGCCCCGAGCATGTGCTGTTCGCGCTGGCCGTCAACCCCGACTCCGAGGCCGGACGGATCCTGCGCGAGGTGCAC
ATCACCCCCGAGGCGCTCAAAGAGGCCGCCATCGGCGGGCATGCGGCGGCCCCGCCCACGCCGCGCCCGGCCATCGACAC
CCCCACCTTGGAGGAGTTCGGCCGCGACCTGACCGAGGCGGCCCGCGAAGGCCGCATCGACCCGGTGATCGGCCGGGAGT
CGGAGATCGTCCAGACCATCGAGGTGCTGTCGCGGCGGACCAAGAACAACCCGGTGCTGATCGGCGACCCGGGCGTCGGC
AAGACCGCGATCGCCGAGGGCATCGCCCAGCGCATCGCCGACGGCGAGGTGCCCGAGCCCCTGCTCGGCAAGCGGCTGGT
CCAGCTCGACCTGTCGGGAGTGGTGGCCGGCACCCGCTACCGGGGCGACTTCGAAGAGCGATTGCGCAAGCTGATCGATG
AGATCCGCGACAACTCCGAGCATTTGGTGATCTTCATCGACGAGCTGCACACCGCGGTGACCGCCGGCGGCGGGGAGGGC
GCGATGACCGCCGGCAACATGCTCAAACCCCCGCTGGCCCGCGGCGAGCTGCACGTCATCGGCGCCACCACCATCGACGA
GTACCGCAAGCACATCGAAAAGGACCCCGCCTTCGAACGCCGCTTCCAGCCCATCTTGGTGCCCGAGCCGTCGGTGGAGG
ACAGCGTGGAGATCCTGCGCGGCCTGCGCGACCGCTACGAGGCCCACCACCAGGTCCGCTTCAGCGACGAGGCGCTGGTG
GCCGCGGTGGAGCTGGCCGACCGCTACCTGACCGACCGGTTCCTGCCCGACAAGGCCATCGATTTGATCGACCACGCCGG
TGCGCGGGTGCGGCTGCGCACCCGGACGCCCGGCCGGGACGTGCGGGACCTGGACCGGCAGATCGAACAGGTGCGCCGGG
AAAAGGACCAGGCCGTCGCCGAGGAGAACTACGACCGCGCCAAGAAGCTGCGCGAGCAGCTCAATGAGCTGGAGCGGCGC
CGGGACGGGCTGCCGCACCCCGCCGGCGCCGCGGCGGTGCCCGAGGTGACCGTCGAGGACATCGCCGAGGTGGTCTCCCG
CAGCAGCGGCATCCCGGTCTCCCGCCTCACCCAGGAAGAGCGCGAGCGCCTGCTGGGGCTGGAAGGGCAGCTGCAGCGGC
GGGTGATCGGGCAGGACGAGGCGGTGGCCGCGGTCGCCGAGGCGGTGCGCCGCTCCCGGGTGGGGATGGGCGACCCGAAC
CGCCCCATCGGCAGCTTCCTGTTCCTGGGCCCGACCGGGGTGGGCAAGACCGAACTGGCCCGCACGCTGGCCGAGGCGCT
GTTCGGCAGCCAGGACCGCATGGTCCGGCTCGACATGAGCGAGTTCCAAGAGCCCCACACCGTCAGCCGGCTGACCGGCG
CGCCGCCCGGCTACCTCGGCTATGAGGAGGCCGGGCAGCTCACCGAGGCGGTGCGCCGCCGCCCGTACTCGGTGCTGCTG
CTGGACGAGATCGAAAAGGCCCACCCGGATGTGTTCAACGTGCTGCTGCAGCTGCTGGACGACGGCCGGCTCACCGACGC
CCAGGGCCGCACCGTCGACTTCCGCAACACCGTGGTGATCATGACCAGCAATCTCGGCTCGGACGTGATCGGCGGCACGG
TGTCGCTGGGGTTCACCCCCGACGGCGGCGACGGGGTGGACTCGGCGGTGCGCGAGCGGGTGATGGGGCGGCTGCGCGAG
GCGTTCCGCCCGGAGTTCCTCAACCGGATCGACGAGATCATCGTCTTCCGCCGGCTGGAGCCCGAGCAGCTGCGCCAGAT
CACCGAGCTGCTGCTGGAGGAGACCCGCCGCCGGCTGCACGCCCAGGACGTCACCGTGCAGTTCACCCCCGAGGCGATCG
GCTGGCTGGCCCGCAAGGGCTACCAGCCGGAGTACGGCGCCCGCCCGCTGCGCCGCACCATCCAGCGGGAACTGGACAAC
CCGCTGTCGAACATGCTGCTGGACGGCAGGCTGCACCCCGGCCAGCACGTGGTGGTCAGCGTCCGCGGCGACGCGCTGGA
TCTGCAGGTGACCGCCGCCCGGCAGATCGCCGCCGCCAGGCCCTCCTGA

Protein sequence :
MGGDWQEQEGKDPFEELLARFFGAAGVHRAVERVNLARLMSEPGRDLIRDAAARAAEWGSSDLDTDHLLWAVTRQEATRH
LLSRAGTDPEELAVRVEGHIERGPARDTPPMMTPSAKRALLDAFQISRAVGSSYIGPEHVLFALAVNPDSEAGRILREVH
ITPEALKEAAIGGHAAAPPTPRPAIDTPTLEEFGRDLTEAAREGRIDPVIGRESEIVQTIEVLSRRTKNNPVLIGDPGVG
KTAIAEGIAQRIADGEVPEPLLGKRLVQLDLSGVVAGTRYRGDFEERLRKLIDEIRDNSEHLVIFIDELHTAVTAGGGEG
AMTAGNMLKPPLARGELHVIGATTIDEYRKHIEKDPAFERRFQPILVPEPSVEDSVEILRGLRDRYEAHHQVRFSDEALV
AAVELADRYLTDRFLPDKAIDLIDHAGARVRLRTRTPGRDVRDLDRQIEQVRREKDQAVAEENYDRAKKLREQLNELERR
RDGLPHPAGAAAVPEVTVEDIAEVVSRSSGIPVSRLTQEERERLLGLEGQLQRRVIGQDEAVAAVAEAVRRSRVGMGDPN
RPIGSFLFLGPTGVGKTELARTLAEALFGSQDRMVRLDMSEFQEPHTVSRLTGAPPGYLGYEEAGQLTEAVRRRPYSVLL
LDEIEKAHPDVFNVLLQLLDDGRLTDAQGRTVDFRNTVVIMTSNLGSDVIGGTVSLGFTPDGGDGVDSAVRERVMGRLRE
AFRPEFLNRIDEIIVFRRLEPEQLRQITELLLEETRRRLHAQDVTVQFTPEAIGWLARKGYQPEYGARPLRRTIQRELDN
PLSNMLLDGRLHPGQHVVVSVRGDALDLQVTAARQIAAARPS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 6e-158 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tcur_2966 YP_003300546.1 ATPase AAA-2 domain-containing protein VFG0079 Protein 3e-178 52
Tcur_2966 YP_003300546.1 ATPase AAA-2 domain-containing protein VFG0080 Protein 1e-136 48