Gene Information

Name : Tcur_2065 (Tcur_2065)
Accession : YP_003299670.1
Strain : Thermomonospora curvata DSM 43183
Genome accession: NC_013510
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 2427682 - 2429403 bp
Length : 1722 bp
Strand : -
Note : KEGG: bov:BOV_1314 urease subunit alpha; TIGRFAM: urease, alpha subunit; PFAM: amidohydrolase; Urease alpha-subunit domain protein; Amidohydrolase 3

DNA sequence :
ATGGCCACCATGAGCCGCAAGCAGTACGCGACGATGTACGGCCCGACGGTGGGCGACAGGTTCCGCCTGGGCGACACCAA
CCTCATCGTCGAGGTGGAAAAAGACCACATCGCGGGGCATTACGGGGACGAGACCCAGTACGGGGGCGGCAAGACCGCCC
GGGACGGCATGTCGGCCGACCCGGCCTCCGGCAGCTCGGTCGCGTTGGACCTGGTGATCACCAACGTGGTGGTGATGGAC
CCGGTGCTGGGCATCGTCAAGGGCGACATCGGCGTCAAGGACGGCCGGATCGCCGGGATCGGCAAGTCCGGCAACCCGCA
CACCCAGGACGGGGTGGACCGGCGCCTGATCGTCAGCGCCAGCACCGAGGTGGTCTCCGGGGAGAACCTCATCGCCACCC
CCGGGGCGATCGACACCCACGTGCACTTCCTGTCCCCGCAGCAGGCCCAGCACGCGCTCAGCAACGGGATCACCACGCTG
CTGGGCGGCGGCACCGGCCCGGCCGACGGCAGCCGCGGCTGCACCACCACCCCGGGGCCGTGGAACATCGCCCGCATCCT
GCAGGCCTATGAGAGCGTCCCGATCAACATCGGGGTGCTCGGCAAGGGCAACAGCAGCCTGCCGGTGCCGCTGGAGGAGC
AGATCCGCGCCGGGGCCTGCGGGCTGAAGGTGCACGAGGACTGGGGCACCACCCCGGCCGTCATCGACTGCGCGCTGTCG
GTGGCCGACGAGTTCGACATCCAGGTCAACATCCACACCGACACGCTCAACGAGGCCGGTTACGTCGAGGACACCATCGC
CGCCATCAACGGCCGGGCCATCCACACCTACCACTCCGAGGGCGCCGGCGGCGGTCACGCCCCCGACATCCTGCGGGTGA
CCGGGGAGCCCAACGTGCTGCCGGCCTCCACCAACCCGACCCTGCCGTACACCGGCAACTCGGTGGATGAGCTGCTGGAC
ATGACCATGGTCTGCCACCACCTCAGCTACGACGTGCCCGAGGACGTGGCGTTCGCCGACAGCCGGGTGCGCGCCGAGAC
CATCTCGGCCGAGACGGTGCTGCACGACCTGGGCATCATCAGCATCATCGGGTCGGACTCCCAGGCGATGGGCCGGGTGG
GCGAGTCCTTCACCCGCGCCTTCCAGATGGCCCACCACAACAAGGACAAGCGCGGCCCGCTGCCGGAGGACTCCTCCCGC
AACGACAACTTCCGGGTGCTGCGCTACCTGGCCAAGCTCACCATCAACCCGGCCCGGGCCAGCGGGATGGCCGACACCAT
CGGGTCGCTGGAGGACGGCAAGCTCGCCGACATCGTGCTGTGGCCGATCCACTCCTTCGCGGCCAAGCCGCTCATGGTGA
TCAAGGGCGGCATGATCAACTGGGCGCAGATGGGCGACCCGAACGCCTCCCTGCCCACGCCGCAGCCGGTGCGGTTCCGT
CCCACCTACGGGGCCTACGGCGAGGCGCTCAGCACCACCTGCGTGACGTTCATGTCCATCGCCGCGATCGAGGCGGGCGT
GCCCGAGCGGCTGGGCCTCAAGCGGCTGATCCGGCCGGTGAGCCAGTGCCGGACCGTCGACAAGCGGCACATGCTGCACA
ACTCGACGCTCGCGGAGATCAAGGTCGATCCGGAGACCTACCGGGTGACCGTGGACGGGGAGCCGGCGCACATCGAACCG
GCCACGAAGCTGCCGCTGAACCGATTGTTCTTCCTGGCATGA

Protein sequence :
MATMSRKQYATMYGPTVGDRFRLGDTNLIVEVEKDHIAGHYGDETQYGGGKTARDGMSADPASGSSVALDLVITNVVVMD
PVLGIVKGDIGVKDGRIAGIGKSGNPHTQDGVDRRLIVSASTEVVSGENLIATPGAIDTHVHFLSPQQAQHALSNGITTL
LGGGTGPADGSRGCTTTPGPWNIARILQAYESVPINIGVLGKGNSSLPVPLEEQIRAGACGLKVHEDWGTTPAVIDCALS
VADEFDIQVNIHTDTLNEAGYVEDTIAAINGRAIHTYHSEGAGGGHAPDILRVTGEPNVLPASTNPTLPYTGNSVDELLD
MTMVCHHLSYDVPEDVAFADSRVRAETISAETVLHDLGIISIIGSDSQAMGRVGESFTRAFQMAHHNKDKRGPLPEDSSR
NDNFRVLRYLAKLTINPARASGMADTIGSLEDGKLADIVLWPIHSFAAKPLMVIKGGMINWAQMGDPNASLPTPQPVRFR
PTYGAYGEALSTTCVTFMSIAAIEAGVPERLGLKRLIRPVSQCRTVDKRHMLHNSTLAEIKVDPETYRVTVDGEPAHIEP
ATKLPLNRLFFLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 8e-145 58
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 8e-145 58
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-141 57
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-141 57
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-141 57
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-141 57

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tcur_2065 YP_003299670.1 urease subunit alpha VFG0270 Protein 7e-138 57