Gene Information

Name : Tcur_2040 (Tcur_2040)
Accession : YP_003299645.1
Strain : Thermomonospora curvata DSM 43183
Genome accession: NC_013510
Putative virulence/resistance : Resistance
Product : beta-lactamase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG2602
EC number : 3.5.2.6
Position : 2401262 - 2402164 bp
Length : 903 bp
Strand : +
Note : PFAM: penicillin-binding protein transpeptidase; KEGG: pla:Plav_3016 beta-lactamase

DNA sequence :
ATGCCACCTCACCGTCCCGCACCGGCCCCCCGGCGTCCGCGGACCGGGCGGCTCGCCGCCGTCCTCACCGCGCTGACGCT
CCTCGGCGCCGCCTGCGCGGCCCCCGCCACCCCGCCGCGGGCCGCGCAGAGCACCACCGCGACCGCGCCGCACAGCCGGC
CGGCGTCCCCGCAGGTCCGCGACGATCTGCTGGAGGTCTTCCGCCAGGCCTCCGTCACCGGAACGTTCGTGCTGATGGAG
GCGGAAAGCGGCCGCACCACCGTGGTCGGCCGCGAACGTGCCGCCCGCCGCTACGTGCCCGCCTCCACCTTCAAGATCCC
CCACAGCCTGATCGCCCTGGAGACGGGCGCGGTCGCAGACGCCGAGGAGGTGATCCCCTACGGGGGACGGCCCCAGCCCC
GTCCCGAATGGGAACGGGACATGACCTTGCGCGAGGCGATCGCGGCCTCCAACGTGCCGGTGTTCCAAACCCTGGCCCGC
CGGATCGGCCTGGCACGGGAACGGCACTGGCTGCGGCGGCTCGGCTACGGCAACCGGCAGACCGGCACGGCGCTCGACCG
CTTCTGGCTGGACGGGCCGCTGGCGATCTCGGCGCTCGAACAGACCGGCTTCCTGGCGCGCCTGGCCACCGGGCGGCTGC
CGGCCTCCCGCCGCCACCAGCGCCTCGTCCGCGACCTGCTGCGCGTCGAACGCACCGTGGACTACGCGTTGTTCGCCAAG
ACCGGCTGGGGCACGGCCGGCGACCCCGGCATCGGCTGGTGGGTCGGCTGGGTCGAACGCGACGGCCGGATCTGGACCTT
CGCCCTCAACATCGACGTCGGCGACGACCGCGACGCCGCCCTGCGGATCCCGCTGGGACGGAGACTGCTGCACCGCCTGG
GCGTGCTGCCGTACCCCGCCTAG

Protein sequence :
MPPHRPAPAPRRPRTGRLAAVLTALTLLGAACAAPATPPRAAQSTTATAPHSRPASPQVRDDLLEVFRQASVTGTFVLME
AESGRTTVVGRERAARRYVPASTFKIPHSLIALETGAVADAEEVIPYGGRPQPRPEWERDMTLREAIAASNVPVFQTLAR
RIGLARERHWLRRLGYGNRQTGTALDRFWLDGPLAISALEQTGFLARLATGRLPASRRHQRLVRDLLRVERTVDYALFAK
TGWGTAGDPGIGWWVGWVERDGRIWTFALNIDVGDDRDAALRIPLGRRLLHRLGVLPYPA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
blaOXA-129 AET25386.1 OXA-129 beta-lactamase Not tested PAGI-2(C) Protein 2e-44 46
bla OXA-129 AFG30109.1 OXA-129 beta-lactamase Not tested PAGI-2 Protein 2e-44 46
ACICU_00226 YP_001844885.1 Beta-lactamase class D Not tested AbaR20 Protein 1e-29 43
bla OXA-10 CAJ77047.1 Oxacillinase Not tested AbaR1 Protein 2e-45 42
blaOXA-2 YP_005176242.1 beta-lactamase OXA-2 protein Not tested ICEPmu1 Protein 4e-29 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tcur_2040 YP_003299645.1 beta-lactamase AM932669.1.gene2.p01 Protein 1e-44 46
Tcur_2040 YP_003299645.1 beta-lactamase X58272.1.gene1.p01 Protein 4e-44 44
Tcur_2040 YP_003299645.1 beta-lactamase AY423074.1.gene1.p01 Protein 6e-37 44
Tcur_2040 YP_003299645.1 beta-lactamase AF024602.1.gene3.p01 Protein 5e-30 43
Tcur_2040 YP_003299645.1 beta-lactamase AY343493.1.gene1.p01 Protein 2e-34 43
Tcur_2040 YP_003299645.1 beta-lactamase NC_010410.6002874.p0 Protein 1e-45 42
Tcur_2040 YP_003299645.1 beta-lactamase U37105.2.gene2.p01 Protein 1e-45 42
Tcur_2040 YP_003299645.1 beta-lactamase EU086830.1.gene1.p01 Protein 5e-39 42
Tcur_2040 YP_003299645.1 beta-lactamase EU086834.1.gene1.p01 Protein 5e-39 42
Tcur_2040 YP_003299645.1 beta-lactamase JF273470.1.gene1.p01 Protein 3e-39 42
Tcur_2040 YP_003299645.1 beta-lactamase AF300985.1.gene1.p01 Protein 5e-29 41
Tcur_2040 YP_003299645.1 beta-lactamase DQ519090.1.gene1.p01 Protein 2e-39 41
Tcur_2040 YP_003299645.1 beta-lactamase NC_010481.6155789.p0 Protein 1e-39 41
Tcur_2040 YP_003299645.1 beta-lactamase EF102240.1.gene13.p0 Protein 2e-39 41
Tcur_2040 YP_003299645.1 beta-lactamase AY665723.gene.p01 Protein 1e-39 41
Tcur_2040 YP_003299645.1 beta-lactamase GU831575.1.gene1.p01 Protein 1e-39 41
Tcur_2040 YP_003299645.1 beta-lactamase HM570036.1.gene1.p01 Protein 2e-35 41
Tcur_2040 YP_003299645.1 beta-lactamase AF371964.1.gene1.p1 Protein 1e-29 41
Tcur_2040 YP_003299645.1 beta-lactamase AY139598.1.gene3.p01 Protein 6e-29 41
Tcur_2040 YP_003299645.1 beta-lactamase U59183.1.gene3.p01 Protein 5e-45 41
Tcur_2040 YP_003299645.1 beta-lactamase AY445080.1.gene1.p01 Protein 2e-45 41
Tcur_2040 YP_003299645.1 beta-lactamase AF231133.1.gene3.p01 Protein 1e-43 41
Tcur_2040 YP_003299645.1 beta-lactamase AM412777.1.gene1.p01 Protein 3e-45 41
Tcur_2040 YP_003299645.1 beta-lactamase AJ854182.1.gene1.p01 Protein 3e-45 41
Tcur_2040 YP_003299645.1 beta-lactamase Z22590.1.gene1.p01 Protein 4e-45 41
Tcur_2040 YP_003299645.1 beta-lactamase U63835.1.gene1.p01 Protein 4e-29 41
Tcur_2040 YP_003299645.1 beta-lactamase L07945.1.gene1.p01 Protein 1e-29 41
Tcur_2040 YP_003299645.1 beta-lactamase JF795487.1.gene1.p01 Protein 2e-28 41
Tcur_2040 YP_003299645.1 beta-lactamase M95287.gene.p01 Protein 2e-29 41