Gene Information

Name : Gbro_2426 (Gbro_2426)
Accession : YP_003273561.1
Strain : Gordonia bronchialis DSM 43247
Genome accession: NC_013441
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 2588750 - 2590327 bp
Length : 1578 bp
Strand : +
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: mxa:MXAN_3645 2,3-dihydroxybenzoate-AMP ligase

DNA sequence : 
GTGAAGGTTGCTCCCTGGCCCCCGAACCTTGTCGAACGCTACCGCGACCTGGGACTCTGGTCCGGCCACACCTTCAACGA
CGTGCTGCGGTCCCGGGCGCAGGAGCCGGGCAGCGAGCAGCGTCTTGCGGTCATCGACGCCGAGCGCCGACTCACCTACC
GCGACCTCGACGACCGGGTGAGCCGTCTGGCCGCTGGACTGATGGCAGCCGGTATCGGACCCGAGGACCGGGTCGTGGTG
CAGATCCCCAATCGCGTCGGCTACGTGGAGGCGGTGTTCGCGCTGTTCCGGCTCGGCGCGATTCCGGTGTTCACCTTGCC
CGCAAATCGGGAGAGCGAACTGGTCCCGATCGCCCGGGCCGCTGGGGCGGTGGCGATCATCTCGCCGGGCGCCGACCCGG
CAACCGACTTCCGCGCGCTGGCCGAAACGGTGATGGCGCAGGTGGATTCGGTCGGCGTGCTCATCGACGCCGACGATCTC
GAGGCGCACTTCGCCGACCCGGTCGAACATCGGCGCTCGGACCCGGGGGAACTCGCCTTTCTGCAACTCTCCGGGGGCAG
TACCGGCATCCCGAAGCTGATCCCGCGCACACACGACGACTACCTGTACAGCGTGCGCCGGAGCAATGAGTTGTGCGGCG
TCACCGCCGACACCGTCTACATGGCGACTCTGCCTGTCGCACAAAACTTCCCGATGAGTTCACCGGGTATCCTCGGCGCG
ATGCTGGCCGGTGGCACGATCGCGTTGGCCGCGTCGCCGCAGCCGTCGATTGCCTGGGCGCTGATACAGGACGCGGGCGT
GACGATGACCGGGCTGGTGCCGCCACTGGCCCGGTTGTGGACCGAGGTCGCCGAGCGCGGAACCGATTTCGATCTGTCCT
CTCTGCAGACCATCCAGGTGGGTGGCGCACGCTGCCCCGACGAACTGGCCCGCCGGATCGGCCCGGCCCTCGGCGTCACC
CTGCAGCAGGTCTTCGGCATGGCCGAGGGGCTGGTCTGTTACACGCGGCTCGACGACCCGATCGACGAGGTCACCACCAC
CCAGGGCCGGCCGATGTCCGACGACGACCAGCTGCGACTCGTCGACGAGAACGGCGACCCGGTGACGTCGGGGCCCGGGT
TCCTGGAAACGCAGGGGCCGTACACGATTCGCAGCTACTGGCAGGACGCCAGTCCGTCGTCGTTCACGCCCGACGGGTGG
TACCGCACCGGCGACGTGGTGGAGTTCAGCGACCGCGGCAACCTCATCGTGCGCGGGCGGGGTGGGGACCGGATCAACCG
CGGCGGCGAGAAGGTGTCCGCCGAACAGGTCGAGGAACAGCTACTCGGGCATCCCGATGTGCGTGATGCCGTCGTGGTCG
GGGTTTCCGACGCCTATCTCGGCGAACGGACCTGCGCCTACATCATTCCCGCGGATCCGCAGGTACCGCCGACGCTGGCC
GGGATCCGCCGGCACGTACGCGCGGCGGGACTCGCCGAATGGAAGCTCCCCGACGTGGTGAAGGTGATCGAGGCATTCCC
GGAGACGGGTGTCGGCAAGGTCAGCCGTCGCCGTCTGCGGCAACTGCTCGCGGGCTGA

Protein sequence : 
MKVAPWPPNLVERYRDLGLWSGHTFNDVLRSRAQEPGSEQRLAVIDAERRLTYRDLDDRVSRLAAGLMAAGIGPEDRVVV
QIPNRVGYVEAVFALFRLGAIPVFTLPANRESELVPIARAAGAVAIISPGADPATDFRALAETVMAQVDSVGVLIDADDL
EAHFADPVEHRRSDPGELAFLQLSGGSTGIPKLIPRTHDDYLYSVRRSNELCGVTADTVYMATLPVAQNFPMSSPGILGA
MLAGGTIALAASPQPSIAWALIQDAGVTMTGLVPPLARLWTEVAERGTDFDLSSLQTIQVGGARCPDELARRIGPALGVT
LQQVFGMAEGLVCYTRLDDPIDEVTTTQGRPMSDDDQLRLVDENGDPVTSGPGFLETQGPYTIRSYWQDASPSSFTPDGW
YRTGDVVEFSDRGNLIVRGRGGDRINRGGEKVSAEQVEEQLLGHPDVRDAVVVGVSDAYLGERTCAYIIPADPQVPPTLA
GIRRHVRAAGLAEWKLPDVVKVIEAFPETGVGKVSRRRLRQLLAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-88 44
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-87 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 3e-88 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 2e-87 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-87 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 2e-87 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-87 44
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-87 44
ybtE CAA21394.1 - Virulence HPI Protein 2e-87 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Gbro_2426 YP_003273561.1 AMP-dependent synthetase and ligase VFG0168 Protein 7e-104 46
Gbro_2426 YP_003273561.1 AMP-dependent synthetase and ligase VFG1817 Protein 3e-83 43
Gbro_2426 YP_003273561.1 AMP-dependent synthetase and ligase VFG0932 Protein 2e-89 42