Gene Information

Name : guaA (Hneap_0610)
Accession : YP_003262510.1
Strain : Halothiobacillus neapolitanus c2
Genome accession: NC_013422
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 654431 - 656017 bp
Length : 1587 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTTCACACGCAGCCGATATTCATGCCGAACGCATCCTGATTCTGGATTTCGGTTCGCAATACACCCAGCTCATCGC
TCGTCGCGTGCGCGAGTGCGGTGTGTACTGCGAAATTCATTCCTGGGAAGTAGATGATGCGTTCGTGCGCAGTTTTACAC
CGCAAGGCATCATCCTTTCCGGCGGGCCGGAATCAGTTATCGAAGCGACGCCGCCCGCTGCGCCTCAGGCCGTGTTCGAA
TTGGGCGTGCCGGTGCTGGGTATTTGTTACGGCATGCAAACCATGGCGGCGCAACTCGGTGGCGTGGTCGAAAATGCCGA
TCATCGTGAGTTTGGCTACGCCTCCGTGCGTGCACGGGGTCATACGGCGCTGTTGAAAGACATCGAAGACAGCGTCACGC
CGGAAGGCTTTGGTATGCTGGATGTCTGGATGAGCCATGGCGATCATGTCATCGAACTGCCAACTGGCTTCAAACTCATG
GCATCGACCGATAACGCGCCCATCGCCGGCATGGCCGATGAAACGCGCCGGTTTTATGGCGTTCAGTTCCACCCCGAAGT
CACGCATACGCGCCAGGGCCACCGCATTCTGGAGCGATTCGTCCGCCAGATTTGCCAGACGCACGGCCTGTGGAAACCCG
ACAACATCATTGACGACATGCTCGCACGTATCCGCGATCAAATCGGCGGCGACGAGGTGATTCTGGGGTTGTCAGGTGGC
GTCGATTCTTCCGTGGTTGCCGCATTACTGCACAAAGCAATCGGCGACCAGCTCACCTGCATCTTCGTCGACAACGGCCT
GCTGCGGTTGAATGAAGGCGATCAGGTCATGAGCACCTTTGCCCAGCACATGGGCGTGCGCGTGATTCGCGTCGATGCCG
AGGCGCGCTTTCTTGCCGCGCTGGAAGGTGTCGCCGATCCAGAGGACAAACGCAAAATCATTGGCGGCATCTTTGTCGAA
ATCTTCGAAGAGCAGGCCAACCTGCATAAAAATGCAGCCTGGCTGGCTCAAGGCACGATTTATCCCGACGTGATCGAGTC
CGCCGGTTCCAAGACCGGCAAGGCGCACGTCATCAAGTCGCACCACAACGTTGGCGGTTTGCCCGCGCACATGCGTCTGA
AACTACTGGAACCGCTGCGTGAATTGTTCAAGGACGAGGTCCGCAAGATCGGTGTCGAGCTCGGCCTACCGAGCGAGATG
GTGTACCGTCATCCGTTCCCCGGCCCGGGCCTTGGCGTGCGCATCCTGGGTGAAGTGAAAAAACACTACGCCGACCTGCT
GCGCCGCGCCGATGCCATCTTCATCGAAGAACTGCGTGCTGCGGATTTGTACGACAAAGTCTCGCAGGCTTTCGTCGTCT
TCCTGCCGGTCAAATCCGTCGGCGTGATGGGTGACGGCCGCAAGTACGACTACGTGGTAGCCATGCGCGCGGTGGAAACC
ATCGACTTCATGACCGCCCGCTGGGCGCACCTGCCGTATGAATTCCTCGAGCGCGTTTCTTTGCGCATCGTCAACGAGAT
CAACGGCATATCTCGAGTCGTGTACGATGTGACCGGCAAACCACCGGGCACCATCGAATGGGAGTGA

Protein sequence :
MTSHAADIHAERILILDFGSQYTQLIARRVRECGVYCEIHSWEVDDAFVRSFTPQGIILSGGPESVIEATPPAAPQAVFE
LGVPVLGICYGMQTMAAQLGGVVENADHREFGYASVRARGHTALLKDIEDSVTPEGFGMLDVWMSHGDHVIELPTGFKLM
ASTDNAPIAGMADETRRFYGVQFHPEVTHTRQGHRILERFVRQICQTHGLWKPDNIIDDMLARIRDQIGGDEVILGLSGG
VDSSVVAALLHKAIGDQLTCIFVDNGLLRLNEGDQVMSTFAQHMGVRVIRVDAEARFLAALEGVADPEDKRKIIGGIFVE
IFEEQANLHKNAAWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPAHMRLKLLEPLRELFKDEVRKIGVELGLPSEM
VYRHPFPGPGLGVRILGEVKKHYADLLRRADAIFIEELRAADLYDKVSQAFVVFLPVKSVGVMGDGRKYDYVVAMRAVET
IDFMTARWAHLPYEFLERVSLRIVNEINGISRVVYDVTGKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-122 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-122 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-122 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-111 47