Gene Information

Name : Hneap_1612 (Hneap_1612)
Accession : YP_003263487.1
Strain : Halothiobacillus neapolitanus c2
Genome accession: NC_013422
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : -
Position : 1750495 - 1752537 bp
Length : 2043 bp
Strand : -
Note : KEGG: net:Neut_0116 DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein

DNA sequence :
ATGCGTGTGTATTTATGTGAAAAGCCGTCACAGGCTCGGGATATTGCCGCTGTTTTGGGTATTCAGTCCAAAGATAAAAG
CTCAATCACAACCGCCGATGGCGTGGTGACCTGGGCATTCGGCCATCTGCTCGAACAAGCGCCGCCCGATGCCTACGATG
ACTCACTCAAGCGCTGGGCGCTGGCTTCATTGCCGATCGCGCCGACTCAGTGGAAAGTCGAGGTGAAATCGAGCGCCAAG
GATCAATTTAAAGCCATCGCCACCTTGCTTAAAAGGGCCACTGAGGTGGTGATTGCCACCGATGCAGATCGTGAAGGCGA
AATGATTGCGCGCGAGCTGATGGCGTTTGTGGGCTTCAAGGGCAAAGTTCAGCGATTGTGGTTATCTGCCCTCGATGCTG
CTTCGGTCAAAAAAGCCTTGGCAGCTTTGAAGCCGAGTGCTGAAACCGCCGGTTTGTATCAATCGGCCCTTGGTCGGTCG
CGGGCGGATTGGCTGGTGGGGATGAACCTCACGCGGGCATTTACCTTGGCGGGGTGTAGCCAGGGCGGGGAGGGTGTGCG
CAGCGTGGGGCGAGTACAAACTCCAACCTTGAGCCTTGTTGTCGCGCGGGATCGTCAGATTGAGCATTTCAAGCCCGTGC
CTTATTTCGAACTGTTCGGGTTCTTTGAAGCAGGGCAGTCATTCAGTACCAAATGGAAAGTGCCCGAAGGGGCTGGGGAT
GACGCAGGGCGCTGTGTCGACCAATCAATCGTGGATGCCGTCGCCAGCAAAATCACCGGCAAAACGGGCACGGTAAGCCA
GTATGAAACCAAGCGCATTAGTGAAAATCCGCCGCTGCCATTCAGCCTATCTACTCTGCAAAAAACCTGCTCGGCCAAGT
TTGGTTTAGGTGCACAAGAAGTGCTGGATATTGCCCAGGCACTGTACGAAACCCACAAGGCCACCACCTATCCCCGATCG
GATTGCAATTTTCTTCCCGAGGAGCAATTCCAAGAGGCATCTTCCATCGTAACGGCACTGGCCAAGTCAGATACCGAAGT
GCAAGGGATCGTTGATTTGCTAGATTTCAGCCGGAAAAGCCCCGCCTGGAATACCAAAAAAATCACGGCGCACCATGCCA
TCATCCCCACGCAAACGCCGCCAAATATGGATGCGATGAGTGACAACGAGCGCAGAGTCTATGAACTGATTCGTCGCCAA
TATCTCGCGCAATTCTTACCCAACTATGAATATGACCGGACCCAGATTGGCATCAGCATCGAGGGCGAGTTATTTCAGAC
CACCGGCAAAATTGACCAAGTGACCGGCTGGCGCGTGCTGTTCGGCAAAGCGGATGCCAGTGACGATGAGCCCGATGACG
AGGTGCAAACCTTGCCCGCCTTGACGCAAGGCCAAACGCTGCCGCTGAGTCACACCGAAATTGCCGCCAAACAAACCAAA
CCACCCTCACGCTACACCGAAGGCACCTTGATTGATGCCATGCAAACGATTGGGAAAAACATCACCGATCCACGGCTGAA
GGCCATTCTCAAAGAAAACTCGGGCATCGGCACCGAAGCCACGCGCGCGGGCATTATTGCCAACCTGATTGAACGCGGTT
TCATCACCAAAAAAGGCAAACAGGTCATCAGCAGTGATGTCGGCAGACAATTGATTGATGCACTGCCCGATTCCGTCAAA
AGCCCTGCACTCACTGCCCTGTGGGAGCAGTCACTTGAAGAAATTGCCGAGGGCAAGCGTGAATTGGCGGGATTTGAGGC
CGATGTCGTCAAATTCATCACCGCGATTATCGACCAGATCAAAAAGCAACACGCTGATGCACCAGCACCAACGCGGCCGA
CGGCGGATTGCCCGACCTGCAAGGCGCAAGGCCAAGCTGAAAAAGTCTATTCCATCAAAAAACAATGCCACTACTGGCAC
TGCAAAGCCTGTAACCAATGGTTTGATGACGCCGCCGGAAAGCCCGTGCCGAAAGCAGCGGCAAGTAGCTCGAAAACAAA
GCCCGCACCACGCAAAAAAACTACGGCGAGAAAAGCAAAATGA

Protein sequence :
MRVYLCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSLKRWALASLPIAPTQWKVEVKSSAK
DQFKAIATLLKRATEVVIATDADREGEMIARELMAFVGFKGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRS
RADWLVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFFEAGQSFSTKWKVPEGAGD
DAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRS
DCNFLPEEQFQEASSIVTALAKSDTEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQ
YLAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPLSHTEIAAKQTK
PPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANLIERGFITKKGKQVISSDVGRQLIDALPDSVK
SPALTALWEQSLEEIAEGKRELAGFEADVVKFITAIIDQIKKQHADAPAPTRPTADCPTCKAQGQAEKVYSIKKQCHYWH
CKACNQWFDDAAGKPVPKAAASSSKTKPAPRKKTTARKAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 3e-145 52
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 8e-138 50
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 2e-131 49
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 2e-131 49
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 2e-131 49
topB AAN62194.1 putative DNA topoisomerase III Not tested PAGI-2(C) Protein 4e-144 49
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 7e-144 49
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 2e-125 46
topB AAW83109.1 TopB Not tested GGI Protein 2e-118 43