Gene Information

Name : Hneap_1209 (Hneap_1209)
Accession : YP_003263092.1
Strain : Halothiobacillus neapolitanus c2
Genome accession: NC_013422
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 1313628 - 1315325 bp
Length : 1698 bp
Strand : -
Note : TIGRFAM: mercuric reductase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Heavy metal transport/detoxification protein; FAD dependent oxidoreductase; KEGG: asa:ASA_P4

DNA sequence :
ATGACCACTCTCAAGATCACCGGCATGACCTGCGACTCGTGCGCGGTTCACGTCAAGGACGCCCTGGAGAAAGTCCCCGG
TGTGCGCTCGGCGGAAGTGTCCTACGCCAAGGGCAGCGCCCGGCTCGCTATCGAGGCCGGCACGTCACCCGACGCGCTGA
CGGCCGCTGTGGCCAGACTAGGTTATCGGGCCACGCTCGCCGATGCGCCCGTGGCTCCGGTGGGCGGCGGGCTGCTTGGC
AAGATGTGCGAATGGCTGGGCAGTGATGACAAGGCTGGCGGGGACGGTGACAAGCTCCACATCGCCGTGATCGGCAGCGG
CGGCGCTGCGATGGCGGCGGCGCTGAAAGCCGTCGAGCAAGGTGCGCGCGTCACGCTGATCGAGCGCGGCACCATCGGCG
GCACCTGCGTCAATGTCGGCTGCGTGCCGTCCAAGATCATGATCCGTGCCGCCCACATTGCCCACCTGCGCCGGGAAAGT
CCGTTCGATAGTGGCATTACGGTCGCCGAGCCGGCCATCCAGCGCACAGCGCTGCTGGCCCAGCAGCAAGGCCGCGTCGA
TGAACTGCGTCACGCCAAATACGAAGGCATCTTGGAGGGCAATCCGGCGATTACCGTGCTGCGCGGCGAGGCCCGCTTCA
AGGATCACCAGAGCCTGACTGTGCGCCTGGTTGACGGCGGCGAGCGCATCGTGACGTTCGACCGCTGTCTGGTCGCCACC
GGCGCGAGTCCGGCCGTGCCGCCGATTCCCGGCTTGAAGGACACGCCTTACTGGACTTCCACCGAGGCGCTGGTCAGCGA
GACTATCCCTAAGCGCCTGGCCGTGATCGGCTCATCGGTCGTCGCGCTGGAACTGGCGCAGGCGTTCGCCCGACTCGGAG
CGAAGGTGACGATCCTGGCGCGCAGCACGCTGTTCTTCCGCGAAGACCCGGCCATCGGCGAAGCCGTCACGGCCGCATTC
CGCATGGAAGGCATCGAGGTGCGGGAACACACCCAGGCCAGTCAGGTCGCCTATATCAATGGTGAAGGGGACGGCGAATT
CGTGCTCACCACGACGCACGGCGAACTGCGCGCCGACAAGCTGCTGATCGCCACCGGCCGCTCACCCAACACGCTCAGCC
TGGCGTTGGATGCTGCGGGCGTCACACTCAACCCGCAAGGCGCGATCGTCATCGACCCCGGCATGCGCACCAGCGTGGAA
CACATCTACGCCGCCGGCGACTGCACCGACCAGCCGCAGTTCGTCTATGTGGCGGCGGCGGCCGGCACCCGTGCCGCCAT
CAACATGACCGGCGGTGACACGGCCCTGAACCTGACCGCGATGCCGGCCGTGGTGTTTACCGATCCGCAGGTAGCGACCG
TGGGCTACAGCGAGGCGGAAGCACACCATGACGGCATCGAAACCGACAGTCGCACGCTGACGCTGGACAACGTGCCGAGG
GCGCTTGCCAACTTTGACACACGCGGCTTCATCAAGCTGGTCGTTGAAGAAGGTAGCGGACGCCTGATCGGCGTGCAGGC
GGTCGCGCCGGAAGCGGGCGAACTGATCCAGACCGCCGCGCTGGCGATTCGCAACCGGATGACGGTGCAGGAGCTGGCCG
ACCAGTTGTTCCCCTACCTGACGATGGTCGAGGGGCTGAAACTCGCGGCGCAGACCTTCAACAAGGACGTGAAGCAGCTT
TCCTGCTGCGCCGGGTGA

Protein sequence :
MTTLKITGMTCDSCAVHVKDALEKVPGVRSAEVSYAKGSARLAIEAGTSPDALTAAVARLGYRATLADAPVAPVGGGLLG
KMCEWLGSDDKAGGDGDKLHIAVIGSGGAAMAAALKAVEQGARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRES
PFDSGITVAEPAIQRTALLAQQQGRVDELRHAKYEGILEGNPAITVLRGEARFKDHQSLTVRLVDGGERIVTFDRCLVAT
GASPAVPPIPGLKDTPYWTSTEALVSETIPKRLAVIGSSVVALELAQAFARLGAKVTILARSTLFFREDPAIGEAVTAAF
RMEGIEVREHTQASQVAYINGEGDGEFVLTTTHGELRADKLLIATGRSPNTLSLALDAAGVTLNPQGAIVIDPGMRTSVE
HIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDTALNLTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPR
ALANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQL
SCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 0.0 92
merA AFG30120.1 MerA Not tested PAGI-2 Protein 0.0 92
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 0.0 92
merA ABQ57371.1 MerA Not tested SGI1 Protein 0.0 88
merA AGK07021.1 MerA Not tested SGI1 Protein 0.0 88
merA AGK07079.1 MerA Not tested SGI1 Protein 0.0 88
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 0.0 85
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 0.0 85
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 0.0 80
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 0.0 76

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Hneap_1209 YP_003263092.1 mercuric reductase BAC0652 Protein 0.0 85
Hneap_1209 YP_003263092.1 mercuric reductase BAC0653 Protein 0.0 80
Hneap_1209 YP_003263092.1 mercuric reductase BAC0650 Protein 1e-172 69
Hneap_1209 YP_003263092.1 mercuric reductase BAC0224 Protein 1e-83 41