Gene Information

Name : GYMC61_3185 (GYMC61_3185)
Accession : YP_003254222.1
Strain : Geobacillus sp. Y412MC61
Genome accession: NC_013411
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 3236810 - 3238450 bp
Length : 1641 bp
Strand : -
Note : TIGRFAM: mercuric reductase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Heavy metal transport/detoxification protein; glucose-inhibited division protein A; KEGG: gk

DNA sequence :
ATGAAAACATATCGAATGACCGTCCAAGGCATGACATGCACCGGCTGTGAACAACATGTCGCCAGAGCGCTGGGGGCGAT
TGGGGCCAAGCTGATGGATGTCAGCTTCCAGCGCAGTGAAGCGGTATTCGCGCTGCCTGAGGGCACGGACGTTGACATGG
CGAGACAAGCGGTCAAAAACGCCCATTACGAGCCGGGGGAAGCCGAGGAGATCACCGCATCAGCCAGATCTGTCATCGAT
GGCGAGGGAGAGTATGACTACATCGTCATCGGTTCCGGCGGGGCGGCGTTTTCCTCGGCGATCGAAGCGGTGAAATACGG
GGCGAAAGTGGCGATGGTCGAACGTGGCACGGTCGGGGGGACGTGCGTCAATATCGGCTGCGTGCCGTCAAAGACATTGC
TTCGGGCTGGTGAAATCAATGCGTTGGCGCGAAATCATCCGTTTCTCGGCCTGCATACATCCGCTGGTCCGGTTGATTTG
GCGCCGTTAGTGAAGCAAAAAAATGAGCTGGTCGAGCAGCTTCGCCAAGCGAAATATGCAGACTTGATCGGAGAGTATGG
GTTCGATTTCATCCAAGGGGAAGCCCGATTTGTTGGGCGCCAAACGATTGAAGTGAACGGCCAAACGCTGTCGGCGAAAC
GGTTTTTGATCGCGACAGGCGCTTCCCCGGCTGTGCCGGATATTCGGGGGCTTCATGATGTCGACTACTTGACCAGCACG
ACGTTGCTCGAGCTGAAAAAGGTGCCGAAGCGGCTCGCCGTCATCGGCGCCGGCTACATCGGTATGGAGTTGGGACAACT
GTTCCACCATCTCGGCTCGGAGGTGACGTTGATGCAGCGAAGCCCACGCCTGCTGAAAGAGTATGACCCGGAAATTTCCG
AAGCGGTGGCGCGGGCGCTCACGGAACAAGGCATCCGCATCATCACCGGCGCTTCGTTTGAACGGGTCGAACAAGACGGG
AATACGAAAAAAGTGTATGTGAATGTAGACGGCCGCACCCGGGTCATCGAAGCGGACGAATTGCTCGTGGCTGCCGGGAG
AACGCCGAATACGGCGGCGTTGAACTTGCCAGCAGCCGGTGTGGAAGTCGGGGCGCGCGGGGAAATTTTGATCGACGAAT
ATACACGGACGACGAACCCGTCGATTTATGCGGCAGGCGATGTCACGCTCGGCCCGCAGTTCGTCTATGTCGCGGCCTAT
CAGGGAGCCGTTGCCGCGGCCAATGCCGTCGGCGGGCTGAACAAGCGCTGGGATACGGCCGTCGTTCCGGCGGTGACGTT
CACCCATCCGGCCATCGCCACCGTCGGGTTGACCGAACAGCGGGCGAAAGAAAACGGGTATGACGTGAAAACGTCCGTCC
TGCCGCTTGAGGCGGTGCCGCGCGCGATCGTCAACCGGGAAACGACGGGGGTGTTTAAACTTGTCGCTGAGGCCCGTACG
GGCAAGCTGCTAGGCGCCCACGTTGTTGCGGACAATGCCGGCGAGGTCATTTACGCTGCGACGTTGGCGATTCAATTCGG
ATTAACGATCGACGACCTTCGCCGCACGTTGGCTCCGTATTTAACGATGGCGGAGGGGCTGAAGCTGGCGGCGCTTACGT
TTGACCAAGATGTTTCGAAGTTATCGTGCTGCGCGGGATGA

Protein sequence :
MKTYRMTVQGMTCTGCEQHVARALGAIGAKLMDVSFQRSEAVFALPEGTDVDMARQAVKNAHYEPGEAEEITASARSVID
GEGEYDYIVIGSGGAAFSSAIEAVKYGAKVAMVERGTVGGTCVNIGCVPSKTLLRAGEINALARNHPFLGLHTSAGPVDL
APLVKQKNELVEQLRQAKYADLIGEYGFDFIQGEARFVGRQTIEVNGQTLSAKRFLIATGASPAVPDIRGLHDVDYLTST
TLLELKKVPKRLAVIGAGYIGMELGQLFHHLGSEVTLMQRSPRLLKEYDPEISEAVARALTEQGIRIITGASFERVEQDG
NTKKVYVNVDGRTRVIEADELLVAAGRTPNTAALNLPAAGVEVGARGEILIDEYTRTTNPSIYAAGDVTLGPQFVYVAAY
QGAVAAANAVGGLNKRWDTAVVPAVTFTHPAIATVGLTEQRAKENGYDVKTSVLPLEAVPRAIVNRETTGVFKLVAEART
GKLLGAHVVADNAGEVIYAATLAIQFGLTIDDLRRTLAPYLTMAEGLKLAALTFDQDVSKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 3e-177 65
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 2e-177 65
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 2e-81 44
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 5e-83 44
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-82 43
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-82 43
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-82 43
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-79 43
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-79 43
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 2e-79 43
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 7e-79 42
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 8e-82 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GYMC61_3185 YP_003254222.1 mercuric reductase BAC0224 Protein 0.0 70
GYMC61_3185 YP_003254222.1 mercuric reductase BAC0651 Protein 1e-177 65
GYMC61_3185 YP_003254222.1 mercuric reductase BAC0652 Protein 3e-80 43
GYMC61_3185 YP_003254222.1 mercuric reductase BAC0653 Protein 9e-80 41
GYMC61_3185 YP_003254222.1 mercuric reductase BAC0650 Protein 4e-76 41