Gene Information

Name : thyA (GYMC61_2589)
Accession : YP_003253662.1
Strain : Geobacillus sp. Y412MC61
Genome accession: NC_013411
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2625786 - 2626580 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
TTGCGGCAATATTTGCAGCTTTTGGAGGATATTTTGGAAAACGGCGTCGAAAAAGAAGACCGCACGGGCGTCGGCACGCT
GTCGGTGTTCGGCCGCCAGCTCCGCTTCAACTTGCAAGATGGATTTCCGCTCGTGACAACGAAAAAATTGCATATCCGCT
CCATCATTTATGAACTGCTTTGGTTTTTAAAAGGCGATACGAACGTCCGCTATTTGCAGGAGAATGGCGTGACGATTTGG
GACGAGTGGGCGGACGAAAACGGCGATCTCGGCCCGATTTACGGCGCGCAATGGCGCTCATGGAAAGGGGCGGACGGGAA
AACAATCGACCAGATCGCGTGGGTCGTCGAGGAGATCAAACGAAATCCGAATTCACGCCGGCTGCTTGTGAGCGCTTGGA
ACGTAGCGGAATTGGACGAGATGAAGCTGCCGCCGTGCCATTATGCCTTTCAGTTTTATGTTGCGAACGGTCGGTTGTCG
TGCATGTGGCAGCAGCGCTCCGTTGATACGTTTTTAGGGCTGCCGTTTAACATTGCCAGCTACGCGCTGTTGACGCATAT
GATCGCCCAGCAATGCGACCTCGATGTCGGCGAACTCATTTTCACCGGCGGTGATGTCCATTTGTACAAAAACCATCTCG
AACAGGCGAAACTGCAGCTGACGCGCGAGCCGCGCCCGCTGCCGAAGCTCGTGATCAAACGGAAGCCGCCGTCCATTTTC
GATTACGAATACGACGATTTTGAAATTGTCGGCTACAACCCGCATCCGACGATTAAAGCACCGGTGGCTGTGTAA

Protein sequence :
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIW
DEWADENGDLGPIYGAQWRSWKGADGKTIDQIAWVVEEIKRNPNSRRLLVSAWNVAELDEMKLPPCHYAFQFYVANGRLS
CMWQQRSVDTFLGLPFNIASYALLTHMIAQQCDLDVGELIFTGGDVHLYKNHLEQAKLQLTREPRPLPKLVIKRKPPSIF
DYEYDDFEIVGYNPHPTIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 6e-80 62