Gene Information

Name : smpB (CDR20291_3011)
Accession : YP_003219486.1
Strain : Clostridium difficile R20291
Genome accession: NC_013316
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 3591421 - 3591876 bp
Length : 456 bp
Strand : -
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCTGGTAAAAAAATATTAGCAACAAACAAAAGAGCAAGACATGAATATTTTATAGAAGAAACTTATGAATGTGGAAT
TGAATTAAAAGGAACAGAAGTAAAATCAATAAGACAAGGCAAAGTTAACCTAAGTGATGGATTTGCATCTGTAGATAATA
GTGAAGTATTTTTAAAACAAGTTCATATAAGTCCATATGAGCAAGGAAATATATTCAATGTTGATTCTTTAAGAGTTAGA
AAACTATTACTTCATAAGCATGAAATAAGAAAACTTATTGGAGCAACTACTATAAAGGGGTATTCACTTATACCACTTAG
TTTGTATCTAAAAAACGGTAAAGTTAAAGTAGAGATTGCCTTAGCAAAAGGTAAAAAACTATATGATAAACGTCAAGATA
TGGCTAAGAAAGATGCACAAAGACGTATAGAAAGAGAAATGACAGGTAAGTATTAA

Protein sequence :
MAGKKILATNKRARHEYFIEETYECGIELKGTEVKSIRQGKVNLSDGFASVDNSEVFLKQVHISPYEQGNIFNVDSLRVR
KLLLHKHEIRKLIGATTIKGYSLIPLSLYLKNGKVKVEIALAKGKKLYDKRQDMAKKDAQRRIEREMTGKY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 2e-36 56
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 3e-34 48
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 4e-29 45