Gene Information

Name : vanG (CD196_1549)
Accession : YP_003214576.1
Strain : Clostridium difficile CD196
Genome accession: NC_013315
Putative virulence/resistance : Resistance
Product : D-alanine:D-alanine ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : -
Position : 1800622 - 1801722 bp
Length : 1101 bp
Strand : +
Note : -

DNA sequence :
ATGAATAATAAAAAAATTGCAGTTATATTTGGTGGAAACTCAACAGAATATGATGTATCATTACAATCAGCTTTTGCAGT
ACTTGAGAATTTGAATACGGAAAAATATGATATTATACCAATTGGAATTACAAGGGAGGGTAATTGGTATCATTATATTG
GAGATTATAATAATATCCAGAATAACACTTGGTTTGAAAGGGATACTGATATAATTCCAGTTATTGTTTCGCAGAACCGT
GTCAAAAATGGTATTATTGAATTTTTAATTCCTGATGCTGTTTCTCAGAATCATATTCCAAATAGTGCTATTGAATCATG
TGAAAATGATATTAAATACACTAAACTTGATTTTGTATTTCCTGTATTGCATGGAAAAAATGGAGAAGATGGAACAGTGC
AGGGGTTATTTGAATTGGCAGGTATACAGGTTATTGGATGTGGTACTCTTTCTTCAGCATTATGTATGGACAAAGACAAA
TCACATAAACTTGTTCATTCAGAAGGTATTAAAGTACCAAAATCAATATTACTAAAATACTCAGATAAATTTAATGTGGC
TGAACTGTCAAAAGACTTAACTTATCCATTATTTATAAAACCTGTGCGTGCAGGTTCATCATTTGGTATTAGTAAAATTT
ATAAAAAAGAAGAGTTACAAGTAGCAGTAGACTTGGCTTTTGAACATGATAATGAAGTAATAATTGAGGAAAATATTGAT
GGTTTTGAGGTAGGGTGTGCAGTTTTAGGAAACGATGACTTACTTGTTGGAAGAGTAGATGAAATAGAATTGTCAAAAGG
ATTTTTTGATTATACAGAAAAATATACATTGAAAAGTTCAAAAATTCATATGCCAGCTAGAATTGATTTGGATTGTGAGA
AAAGAATACAAGAGACAGCAAAAATTATTTATAGAACTCTTGGATGTTCTGGATTTGCTAGAGTAGATATGTTTTTAACT
CCATCTGGTGAAATTATTTTTAATGAAGTCAATACAATTCCTGGCTTTACTTCTCATAGTCGTTATCCGAATATGATGAA
AGGTATTGGACTGTCTTTTGAAGAAATATTGGATAAGATAATTGAGGTGTACATAAAATGA

Protein sequence :
MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGITREGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNR
VKNGIIEFLIPDAVSQNHIPNSAIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEELQVAVDLAFEHDNEVIIEENID
GFEVGCAVLGNDDLLVGRVDEIELSKGFFDYTEKYTLKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLT
PSGEIIFNEVNTIPGFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 7e-60 43
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 2e-60 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
vanG YP_003214576.1 D-alanine:D-alanine ligase AY145441.gene.p01 Protein 4e-61 43
vanG YP_003214576.1 D-alanine:D-alanine ligase AF310956.2.orf5.gene Protein 4e-61 43
vanG YP_003214576.1 D-alanine:D-alanine ligase U00456.gene.p01 Protein 9e-61 43
vanG YP_003214576.1 D-alanine:D-alanine ligase U35369.1.gene6.p01 Protein 9e-61 43
vanG YP_003214576.1 D-alanine:D-alanine ligase AE016830.1.gene2250. Protein 9e-61 43
vanG YP_003214576.1 D-alanine:D-alanine ligase AF277571.gene.p01 Protein 2e-58 43
vanG YP_003214576.1 D-alanine:D-alanine ligase AF130997.1.orf4.gene Protein 7e-58 42
vanG YP_003214576.1 D-alanine:D-alanine ligase AY489045.gene.p01 Protein 3e-57 42
vanG YP_003214576.1 D-alanine:D-alanine ligase AF162694.gene.p01 Protein 2e-65 42
vanG YP_003214576.1 D-alanine:D-alanine ligase L29638.gene.p01 Protein 1e-60 41