Gene Information

Name : guaA (Dret_0989)
Accession : YP_003197855.1
Strain : Desulfohalobium retbaense DSM 5692
Genome accession: NC_013223
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1163563 - 1165110 bp
Length : 1548 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCATTTAGAAAATAGAGTCCTGATTCTTGATTTCGGGTCCCAATACACCCAACTGATCGCCAGGCGGGTCCGGGAAGC
CGGCGTGTACTCCGAGATCCATCCCTGCACCACTCCGATCGACGAGTTGCAGGCCATGAAGCCCAGCGCCCTGATCCTTT
CCGGGGGGCCATCCAGTGTCACCGATCCGGACGCCCCGGCCGTGGATCCGGCTATTTTGGAGTGGGACATTCCCATTTTG
GGAATCTGTTACGGCATGCAGCTTCTGGCCACACTTTTGGGCGGCGACGTCGTCCCGGCCCAGGATCGGGAATACGGTCG
GGCTGAGGTCGAAGTCATCGAGAAGTCCCCGTTGTGGAGCGGGATGCATTTCCAGGACCCGGTCAAGGTCTGGATGTCCC
ACGGGGACAAGGTCATGGCCCCGCCGGAGGGGTTTACGGTCCTGGCACGGACGCCGCAAGTCGATGTGGCGGCCATGGGC
AGTGCCGATCGCCGGATCTATGGGCTGCAGTTCCACCCGGAAGTGGTGCACACTGAAGACGGTGACCAGATCCTGCGCAA
TTTCCTCTTCGATGTCGCCGAACTGACCCCGGACTGGACCATGGCCTCGTTTGTGGAGACTATGCGCGACTCCCTGCCAA
CGCTTATCGGTGACGGCAAGGTGGTTTGCGGCCTGAGCGGCGGGATCGACTCCACGGTAGTGGCGGTTTTGCTGCACAAG
GCTATTGGGAAGCAATTGCACTGCATTTTTGTAGACAACGGGCTGTTGCGTCAGGACGAGGGCGAAGAGGTCGTACAGTA
TTTGCGACGGCATTTCGATCTCAATCTCAAGTATGTTCAGGCCCAGGACCGGTTTTTGTCCCGGCTCCACGGTGTTGAAG
ACCCGGAAGAAAAACGGAAGATCATCGGCCATACCTTCATTGAGGTTTTCGAGGAAGAAGCCAAGGAGATCAAGGACGTC
CAGTATCTGGCTCAAGGGACGCTGTATCCGGATGTCATCGAGTCCGTGTCCTTCAAGGGCCCCTCTGCGGTTATCAAAAG
TCATCACAACGTTGGCGGATTGCCGGAACGGATGCAAATGGACCTGGTCGAGCCGTTGCGCGAACTCTTCAAGGATGAAG
TTCGTAAGGTGGCTGTGGAATTGGGATTGCCGGATTTCCTGGTCTGGCGCCACCCCTTTCCCGGACCGGGGCTCGCGATT
CGAGTGATCGGGGAAATCACCCCGGAACGCTTGGAGATCTTGCGTAAGGCGGATAAAATCGTCCATAATGAACTCATGGC
CTCAGGTTGGTATTACAAAGTCTGGCAGGGATTTGCGGTGTTGCTGCCCTTGAAGACCGTTGGGGTCATGGGTGATGAGC
GGACCTATGAACACGTTATCGCCCTGCGGGTGGTCGATAGTGTCGATGCCATGACGGCAGATTGGACCAGGCTGCCACCC
GACTTGTTGGGTCGGATTTCGAATCGGATCATCAATGAGGTCAAAGGAGTGAACCGGGTCGTCTACGACGTGTCCTCCAA
GCCTCCTGGAACCATCGAGTGGGAATAG

Protein sequence :
MHLENRVLILDFGSQYTQLIARRVREAGVYSEIHPCTTPIDELQAMKPSALILSGGPSSVTDPDAPAVDPAILEWDIPIL
GICYGMQLLATLLGGDVVPAQDREYGRAEVEVIEKSPLWSGMHFQDPVKVWMSHGDKVMAPPEGFTVLARTPQVDVAAMG
SADRRIYGLQFHPEVVHTEDGDQILRNFLFDVAELTPDWTMASFVETMRDSLPTLIGDGKVVCGLSGGIDSTVVAVLLHK
AIGKQLHCIFVDNGLLRQDEGEEVVQYLRRHFDLNLKYVQAQDRFLSRLHGVEDPEEKRKIIGHTFIEVFEEEAKEIKDV
QYLAQGTLYPDVIESVSFKGPSAVIKSHHNVGGLPERMQMDLVEPLRELFKDEVRKVAVELGLPDFLVWRHPFPGPGLAI
RVIGEITPERLEILRKADKIVHNELMASGWYYKVWQGFAVLLPLKTVGVMGDERTYEHVIALRVVDSVDAMTADWTRLPP
DLLGRISNRIINEVKGVNRVVYDVSSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-140 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-139 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-139 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-130 53