Gene Information

Name : Dtox_2001 (Dtox_2001)
Accession : YP_003191459.1
Strain : Desulfotomaculum acetoxidans DSM 771
Genome accession: NC_013216
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 2164444 - 2166609 bp
Length : 2166 bp
Strand : -
Note : KEGG: bar:GBAA0375 DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein

DNA sequence :
ATGAAATCACTAGTCTTAGCGGAAAAACCTAGTGTCGCCAGGGAAATTGCCAGGATACTGAACTGTACTATAAAGGGTAA
AGGATACCTTGAGGGCAACAAATATATTGTCACCTGGGCTCTGGGGCACCTGGTAACTCTGGCAGAACCGGAGGATTATG
ACGAGAAATACAAGACCTGGCGAACAGAAGACCTGCCCATGCTGCCTGCTGAAATGAAAACCGTGGTAATCAAGAAAACA
GGTCCACAGTTTCATATAGTAAGCAAATTGATGAAACGTCCGGATGTCCGGGAATTGATTATTGCCACCGACGCCGGGCG
GGAGGGAGAACTTGTGGCCAGATGGATCATGAAACAGGCCCGCTGCCAAAAACCTTTTAAACGCCTATGGATATCTTCGC
TGACTGACGAAGCTATCAGAGAAGGCTTTACCAGGTTAAGACCAGGTACTGAGTATAATAACCTGTATGATTCAGCAATC
TGCCGGGCCGAGGCTGACTGGTTAATCGGACTCAATGTAACCCGGGCCCTTACTGTTAAGTACAATGCCCAGCTGTCTGC
CGGACGGGTACAGACCCCCACTCTGGCCATGCTGGTTAGCCGGGAAAAAGAGATAAAAAGGTTTGTGCCGACTGATTTCT
GGACAGTCAAGGCTAATTTGGGCAAATTCCAGGCTGAATGGCGAGATAAGTCAGGAAAACATAACCGATTTTCTGATTGC
CTGCAAGCAGAAACAATTGTTAATAAGGTAAAAGAAAAGTCCGGAGAAGTAATCGATCTTATAACTCAGGAAAAAAGTGA
GCAACCTCCTCTGGCTTATGACTTGACCGAACTGCAAAGGGATGCCAATAAAAAGTTCGGCTACACAGCACAGAAAACTC
TTGCAGGCCTGCAAATGCTGTATGAAAGACATAAGTTAGTAACTTATCCCAGAACCGACTCGCGCTATTTAACCTCTGAT
ATGGTACCAACACTGATGCCCAGATTGAAAGCCGTATCGGGCGGTTATTTCGCAGAACTGGTTAAGCCATTGACCGCAAA
ACCCTTGCCGATAAACAAAAGACTGGTGGATAACAGCAAGGTTACCGACCACCACGCAATTATACCTACCACAGAAAGAG
CCAACCTGGCGGCATTGACTGCCGAGGAAAAAAATATCTATGATTTAATAGTACGGCGTTTCATAGCTGTATTCTACCCG
GCCTACAGCTATAAGCAAACAACTGTTATAGTGCTCATAGCAGGTGAACATTTTCATGCATCAGGTAAGGTAGTTACCAA
TCCAGGCTGGAAGGCTGTTTATAATAATGAATCAAGGGAGAAAGACACAGGCTATGACGACACTCCGGAACAGAATTTGC
CGCCGCTTAAAAAAGGTGACAAAGTAAAGGTACTGTCCTGCAAGTCTGTTAAAGGACAAACCAAACCGCCGGCCCGCTAT
ACAGAAGCCAGCTTACTTTCGGCTATGGAACACCCGGGTAAATTTATTGAGGACGAGATACTGAAAGAATCTGTGAAGGA
AAGTGGACTGGGCACCCCCGCGACAAGGGCGGAAATAATAGAAAAGATTATCTCCTCTAATTATGTCGAACGGCGTGGAA
AAGAGTTAATCCCCACAGCCAAAGGCATTCAATTAGTAGAACTCGTACCGCCTGAGCTAAAGCAGGCAGACTTAACTGCT
AAATGGGAGCAGCAGCTGCATGATATAGCTATGGGTAAATCCAAACGCACAAAGTTCATTTCAGGCATCAGAGAGCACGC
AGAGAAAATTGTAACTACCGTATTGAACAGTTCCAGCACTTTTAAACCGGATAATGTTACCGGCAACAAGTGTCCCAAAT
GTAGAAAGTTTCTGCTTTCAGTAAAAACTAAAAGAGGCAGCAACCTGGTCTGTCCTGACCGTAGCTGCGGACACAGGCAG
GTAGAAAAAGAAACCAGCAACAGGCCCTGCCCCCAGTGTAAAAAGAGAAGGATGGAAATCAGAGAAGGCAAGGGCGGTAA
GATTATTGTCTGCACTCACTGCCGGTACCAGGAAAAATATGTATTACAGCCTAAACGTGAAGCAAAGGTCAATATAAAGG
CTTACAGTGACAGCGCGCCTCTGGTAACAAACCTGTCAATTCTGGCCAATTTTAAATTTAACGGGGCTAAAGAAAAAAGT
GATTAG

Protein sequence :
MKSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWRTEDLPMLPAEMKTVVIKKT
GPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMKQARCQKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAI
CRAEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLGKFQAEWRDKSGKHNRFSDC
LQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTELQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSD
MVPTLMPRLKAVSGGYFAELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVFYP
AYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKKGDKVKVLSCKSVKGQTKPPARY
TEASLLSAMEHPGKFIEDEILKESVKESGLGTPATRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTA
KWEQQLHDIAMGKSKRTKFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSCGHRQ
VEKETSNRPCPQCKKRRMEIREGKGGKIIVCTHCRYQEKYVLQPKREAKVNIKAYSDSAPLVTNLSILANFKFNGAKEKS
D

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB-2 NP_815968.1 DNA topoisomerase III Not tested Not named Protein 5e-109 43
EFAU085_00720 YP_008394244.1 DNA topoisomerase III Not tested Not named Protein 7e-116 42