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Name : ureC (CAP2UW1_1203) Accession : YP_003166460.1 Strain : Candidatus Accumulibacter phosphatis UW-1 Genome accession: NC_013194 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 1377743 - 1379458 bp Length : 1716 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGCGTCCGCATCTCGCGCCAGGCCTATGCCGAAATGTTCGGGCCAACCGTCGGCGACCGCGTCCGCCTCGCCGACAC CGATCTGTGGATCGAGGTCGAGCGGGATCTCACCGTTTATGGCGACGAGGTCAAGTTCGGCGGCGGCAAGGTGATCCGCG ACGGCATGGGGCAGGGCCAGAAGGTCGCCGCGGAAGTCGCCGACACGGTGATCACCAATGCGCTGATCGTCGACCACTGG GGTATCGTCAAGGCCGACATCGCCATCAAGGGCGGCCACATCGCTGCCATCGGCAAGGCCGGCAATCCGGACATTCAGCC GGGCGTGACGATCGCCATCGGCGGCGCCACCGAGATCATCGCCGGCGAAGGGATGATCGTCACCGCCGGCGGCATCGACA GCCATATCCACTTCATCTGCCCGCAGCAGATCGACGAGGCGCTGATGTCGGGCGTGACGACGATGCTGGGTGGTGGCACC GGCCCGGCGACCGGCACCTACGCAACCACCTGTACTCCCGGACCCTGGCACATCCACCGCATGCTCGAAGCCGCCGAGGC GTTTCCGATGAACCTCGGCTTCCTCGGCAAGGGCAACGTGTCGCTTCCTGAACCCTTGCGCGAGCAAGTGCGCGCCGGAG CCATCGGCCTCAAGCTGCACGAGGACTGGGGAACGACGCCGGCGGCGATCGACAACTGCCTGGCGGTGGCCGACGCGATG GACGTGCAGGTGGCGATCCACACCGACACGCTCAACGAATCGGGCTTCGTCGAAACGACGCTTGCCGCCTTCAAGGGGCG AACGATCCACACCTTCCATACCGAGGGTGCCGGCGGCGGCCACGCACCGGACATCCTGCGCGCCGTCGGCGAGACCAACG TCCTGCCCTCGTCGACCAACCCGACGCGGCCCTACACGGTGAATACCGTCGACGAACACCTCGACATGCTGATGGTCTGT CACCACCTCGACCCGGCGATCGCCGAGGACGTCGCTTTCGCCGAAAGCCGCATCCGGCGCGAGACGATCGCCGCCGAGGA CATCCTGCACGACCTCGGCGCGCTGTCGATGATGTCGTCCGACTCGCAGGCGATGGGCCGCGTCGGCGAAGTGATCATCC GCACCTGGCAGACGGCGCACAAGATGAAGGCGAAGCGTGGCCACCTGCCCGCCGCAGCGGGTGATCCGGCGAGCGCGCAT GACAACTTCCGCGTCAAGCGTTACCTCGCCAAGTACACGATCAACCCGGCGATCACGCATGGCATCAGCCATCTCGTCGG TTCGATCGAAGTCGGCAAGCTCGCCGATCTGGTGCTCTGGAAGCCCGCTTTCTTCGGCGTCAAGCCGTCGTTGATTGTCA AGGGCGGGATGATCGCCGCGGCGGCGATGGGCGACCCCAATGCGTCGATTCCGACGCCACAGCCAGTGCACTACCGGCCG ATGTTCGGCGCCTTCGGGCGGGCGCTGCGAACTTCGGTGACCTTCGTCTCACAGGCGGCACTCGCCAATCCCGAGGTGGC GGCGCTGCAGTTGAGCAAGCCGCTGGTCGCCGTTCGCGGGACGCGCGGGATTGGCAAACCCGATATGGTGCATAACTACG CGACGCCGAAGATCGACGTCGACCCCGAAACCTATGTCGTCCGCGCCGACGGCGAACTCCTGGTCTGCGAACCGGCGAGC GTGCTGCCGATGGCGCAACGTTACTTTCTCTTCTGA Protein sequence : MSVRISRQAYAEMFGPTVGDRVRLADTDLWIEVERDLTVYGDEVKFGGGKVIRDGMGQGQKVAAEVADTVITNALIVDHW GIVKADIAIKGGHIAAIGKAGNPDIQPGVTIAIGGATEIIAGEGMIVTAGGIDSHIHFICPQQIDEALMSGVTTMLGGGT GPATGTYATTCTPGPWHIHRMLEAAEAFPMNLGFLGKGNVSLPEPLREQVRAGAIGLKLHEDWGTTPAAIDNCLAVADAM DVQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDILRAVGETNVLPSSTNPTRPYTVNTVDEHLDMLMVC HHLDPAIAEDVAFAESRIRRETIAAEDILHDLGALSMMSSDSQAMGRVGEVIIRTWQTAHKMKAKRGHLPAAAGDPASAH DNFRVKRYLAKYTINPAITHGISHLVGSIEVGKLADLVLWKPAFFGVKPSLIVKGGMIAAAAMGDPNASIPTPQPVHYRP MFGAFGRALRTSVTFVSQAALANPEVAALQLSKPLVAVRGTRGIGKPDMVHNYATPKIDVDPETYVVRADGELLVCEPAS VLPMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-175 | 73 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-175 | 73 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-150 | 63 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-150 | 63 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-150 | 63 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-150 | 63 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_003166460.1 | urease subunit alpha | VFG0270 | Protein | 8e-144 | 62 |
