Gene Information

Name : guaA (Lebu_2075)
Accession : YP_003164925.1
Strain : Leptotrichia buccalis DSM 1135
Genome accession: NC_013192
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 2206502 - 2208046 bp
Length : 1545 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAAAGAGAAAATTATTATTATTGATTTTGGTTCACAATACAGTCAATTAATTGCCAGAAGAATTAGAGAAATGGAAGT
TTATTGTGAAATTATGCCTTTGGTTGATATTGAAAAAATAAAAAATGGAGAAGAAAAAGTAAAAGGAATTATTTTTTCAG
GAGGTCCTGCTTCCGTTTATGAAAAAGACGCTCCAACTGTAAATCCTGAAGTATTTAACTTAAATCTTCCTATTTTGGGA
ATTTGCTATGGAATGCAGCTAATTACACACTTAAATGGTGGAAAAGTTGAAAAGGCTGATTCAAGGGAGTTTGGAAAAGC
TGTGCTGGAAGTGGAAAATAGTGATAATCCATTGTTTACAGGAGTAAAAAAATCTTCTAACATCTGGATGAGTCACAACG
ACCACATTACAGAATTACCAAAAGATTTTGAAATAATTGCAAAAACAGATTCATCAATCGCCGCAATTACAAATAACAAC
GGAATTTATGCACTTCAATTTCATCCAGAAGTAGTCCATTCTGAATGTGGAACACAAATTTTGGAAAACTTCGTATTTAA
CATCTGTAAATGTGAGAGAAACTGGAAAATTTCAAGCTTTATTGCTGAAAAAACAAAATTTATCAAGAAAACTGTCGGAG
ATGAGCACGTACTGCTTGCACTTTCAGGAGGAGTAGATTCATCAGTTGCCGCGGTTCTAATCAACAATGCAATTGGACAT
CAGCTTACTTGTATGTTCGTAGACACTGGACTTTTGAGAAAAGACGAAGGCAAAAAAGTTCTTGAATACTACAAGGAACA
TTTTGACTTAAACATAGTTTTTGTTGACGCAAAAGATAGATTTTTAAACAAATTAAAAGGTATAGACGAGCCTGAAGCCA
AGAGAAAAATCATCGGAAATGAATTTATCGAAGTCTTTAACGAAGAAATAAGAAAACTGAAAGGACAAGAAGGTGCAAAA
TTCCTAGCACAAGGAACAATTTACCCAGACGTAATTGAATCTCAGTCTATAAAAGGTCCTTCACACACAATAAAATCTCA
CCACAACGTAGGAGGACTACCAGAAGACTTGCAATTTGAACTGTTAGAACCTTTAAAAGAACTATTTAAAGACGAAGTAA
GAAAAGTTGGACACGAACTTGGACTTCCTGACACAATTATAAAAAGACACCCCTTCCCAGGTCCAGGACTTGGAATCAGA
GTTATCGGAGAAGTAACTCCTGACAAAGTAAAAATTCTTCAAGAAGCTGATGATATTTTCATTATCGAATTGATGGAAAA
AGGACTTTACGACAAAGTAGATCAAGCATTCGTAACATTACTACCTGTAAAAACTGTCGGAGTTATGGGCGATCAAAGAA
CTTATGAATACGTAGCAGCTATTCGTTCAGTAAATACAATCGATTTTATGACTGCCACATGGTCAAAACTGCCTTACGAA
TTCCTTGAGGAAGTGTCAAACAAGATTATAAACAAAGTAAACGGAATAAATAGAATTGTGTATGATATTTCTTCTAAGCC
ACCAGGTACTATTGAGTGGGAGTAA

Protein sequence :
MKEKIIIIDFGSQYSQLIARRIREMEVYCEIMPLVDIEKIKNGEEKVKGIIFSGGPASVYEKDAPTVNPEVFNLNLPILG
ICYGMQLITHLNGGKVEKADSREFGKAVLEVENSDNPLFTGVKKSSNIWMSHNDHITELPKDFEIIAKTDSSIAAITNNN
GIYALQFHPEVVHSECGTQILENFVFNICKCERNWKISSFIAEKTKFIKKTVGDEHVLLALSGGVDSSVAAVLINNAIGH
QLTCMFVDTGLLRKDEGKKVLEYYKEHFDLNIVFVDAKDRFLNKLKGIDEPEAKRKIIGNEFIEVFNEEIRKLKGQEGAK
FLAQGTIYPDVIESQSIKGPSHTIKSHHNVGGLPEDLQFELLEPLKELFKDEVRKVGHELGLPDTIIKRHPFPGPGLGIR
VIGEVTPDKVKILQEADDIFIIELMEKGLYDKVDQAFVTLLPVKTVGVMGDQRTYEYVAAIRSVNTIDFMTATWSKLPYE
FLEEVSNKIINKVNGINRIVYDISSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 8e-128 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-128 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-128 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-105 46