Gene Information

Name : leuS (Bfae_12550)
Accession : YP_003154688.1
Strain : Brachybacterium faecium DSM 4810
Genome accession: NC_013172
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : -
Position : 1412559 - 1415516 bp
Length : 2958 bp
Strand : -
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGAGCGAGGCCCCGCACCGATACACCGCCGCCGTGGCGGACGAGATCGAGCTCCGCTGGCAGCAGCGCTGGGACGAGGA
CGGCACCTTCTACGCCGACAACCCCGTCGGCGAGCTGCGCGGCTCGGCAGAGACGCTCGAGGAGGCTGCGGCGACCGCCT
CCTCGGCCCCCGAGAAGATGTACATCATGGACATGTTCCCCTACCCCTCCGGGGCGGGGCTGCACGTGGGCCACCCGCTG
GGCTACATCGCGACCGACGTGGTCGCCCGCCATCAGCGCATGCTGGGCAAGAACGTCCTGTACACGATGGGCTACGACGC
CTTCGGCCTACCCGCCGAGCAGTACGCCGTCCAGACCGGCACCCATCCGCGCACCACCACCGAGGCGAACGTGGCGAACA
TGCGCCGCCAGCTGCACCGCCTGGGCTTGTCCCATGACCCGCGCCGCTCGCTGGCCACCACCGATCCCGCGTTCGTGAAG
TGGACGCAGTGGATCTTCCTGCGCATCTTCGACTCCTGGTACGACCCGCAGGCACCCAATGCCGACGGCATCACCGGCAG
GGCCCGTCCCATCGCCGAGCTGCGCGAGGAGCTGCGCGCCGGCACCGTCGACCCCTTCGCCCTGGCCGCGCAGCAGCGCC
TCGAGCTGCCCGAGGCCTGGCAGGGCCGCTCCCCCGCCGACGTCACCGCGGCCAGCGACGCCGAGATCGCGCAGCTGGCC
GATGCCTTCCGCCTGGCCTACATCTCCGAGACCCCGGTGAACTGGTGCCCGGGCCTGGGCACCGTGCTGGCCAATGAGGA
GGTCACCACCGAGGGCCGCTCCGAGCGCGGCAACTTCCCCGTCTTCACCCGCCGCCTGCGGCAGTGGAACATGCGCATCA
CCGCCTACGCGGACCGGCTGCTGGACGATCTGGAGCGGGTGGACTGGCCCGAGTCGATCCGCACCATGCAGCGCAACTGG
ATCGGCCGCAGCCACGGCGCGGAGATCACCTTCCCGGTGCGCGGCCTGGACGGCCGCGCGGAGGCCGGCTTCGACGTGTT
CACCACCCGCGCGGACACCCTGTTCGGGGCGACGTTCTGCGTCCTCTCGCCCGAGCACGAGCTGCTGACCGACCCCTCCG
CGCTGCCCGCCGCCTGGCCCGAGGGCACGAAGGACGCCTGGACCGGCGGGGCGGCGAACCCGCGCGAGGCCGTGACCGCC
TACCGGGACCGGGCCGCCGCGCTCGGCGACGACGAGCGCACCGCCGACGACCGGGTCAAGACCGGCGTGTTCACGGGCCT
GACCGCGACGAATCCGATGGACGGCCGCGAGCTGCCGGTGTTCACCGCCGACTACGTGCTCACCGGCTACGGGACCGGCG
CGATCATGGCCGTGCCCGCGGAGGACGAGCGCGACCACGAGTTCGCCGAGCGCTTCGAGCTGCCCGTGATCCGCACCGTG
CAGCCGCCGGAGGACTTCACCGGCGGCGCGTGGACCGGGGACGGCATCACGATCAACTCCGCGAGCGCCGAGCTGGACCT
CAACGGCCTGAGCCAGGAGGAGGCCAAGCGACGCGCCACGGAGTTCGTGACCCACCAGGGCTTCGGCCGTGCCCGCACCA
CCTACCGCCTGCGGGACTGGCTGTTCTCGCGGCAGCGCTACTGGGGCGAGCCGTTCCCGATCGTCTACGACCCGGCCGAT
CCGGAGACCCCGATCGCCCTGCCCGAGAGCATGCTGCCGGTGGACCTGCCCGACGTCACCGACTTCTCCCCCAAGACCTT
CGATCCGATGGACGCGGACACCGAGCCGCAGACCCCGCTGTCCCGCGCGGGCGACTGGGTCGAGGTGGAGCTGGATCTGG
GCGAGGGCCCGAAGACGTACCTGCGCGAGACCAACACGATGCCGCAGTGGGCGGGGTCCTCCTGGTACCACCTGCGCTAC
ATCGACCCCACCGAGGACGACGTGCTGGTGCGGCCCGAGAACGAGGCCTACTGGCTCGGGGCCCGCGAGGACGGCGGCGC
GGGCGGCGTGGACCTGTACGTGGGCGGGGCCGAGCACGCGGTGCTCCACCTGCTGTACGCGCGGTTCTGGCACAAGGTCC
TCTTCGACCGCGGTGACGTCTCCAGCCAGGAGCCGTTCCAGCGCCTGTTCAACCAGGGCTACATCCAGGCCTACGCCTAC
ACCGATTCCCGCGGCGTGCACGTCCCGGCGGAGGAGGTCGTCGCGGAGGCCGACGGCACCTACACGTACCAGGGCGAGCC
CGTCACGCAGGAGTACGGCAAGATGGGCAAGTCGCTGAAGAACGCGGTGGCGCCCGACGACATGTACGAGGAGTACGGCG
CCGACACCCTGCGCGTGTACGAGATGTCGATGGGCCCGCTGGACCTCTCCCGGCCCTGGGAGACCCGGGCCGTGGTGGGC
TCCCAGCGCTTCCTGCAGCGCCTGTGGCGCCTGGTGGTCGACGAGGAGACCGGCGTGCTGACGGTCTCCGACGAGCCGGC
CGATCTCGCCACGAAGCAGGCCGCGCACCGGACGATCGACGGTGTGGCCCGCGACATGGACCGGATGCACTTCAACACCG
CGATCGCGAAGCTCATCGAGCTGGTGAACCACCTGACCAAGCAGCTGACCTCGACGGGCTCCACGCCCCGCGAGGCGGTC
GAGCCGCTCGTGCTCCTGGTCGCGCCGCTGGCCCCGCACCTGGCGGAGGAGCTGTGGGCGCGGCTGGGGCACACCGGCAG
CATCAGCCGTGTGCCGTACCCGGCCGCGGATCCGGAGCTGCTGAAGGACGAGCAGGTCACCTGCGTCATCCAGGTCAAGG
GCAAGGTGCGCCACCGCATCGAGGTCGATCCGGAGATCTCCGAGGAGGATCTGGAGGCGGCGGTGATGGCCGAGCCGCGC
GTGCAGGAGCTGCTGGAGGGCCAGACCCTCCGCAAGCTCATCATCCGTGCGCCGAAGATCGTGAACATCGTGATCTGA

Protein sequence :
MSEAPHRYTAAVADEIELRWQQRWDEDGTFYADNPVGELRGSAETLEEAAATASSAPEKMYIMDMFPYPSGAGLHVGHPL
GYIATDVVARHQRMLGKNVLYTMGYDAFGLPAEQYAVQTGTHPRTTTEANVANMRRQLHRLGLSHDPRRSLATTDPAFVK
WTQWIFLRIFDSWYDPQAPNADGITGRARPIAELREELRAGTVDPFALAAQQRLELPEAWQGRSPADVTAASDAEIAQLA
DAFRLAYISETPVNWCPGLGTVLANEEVTTEGRSERGNFPVFTRRLRQWNMRITAYADRLLDDLERVDWPESIRTMQRNW
IGRSHGAEITFPVRGLDGRAEAGFDVFTTRADTLFGATFCVLSPEHELLTDPSALPAAWPEGTKDAWTGGAANPREAVTA
YRDRAAALGDDERTADDRVKTGVFTGLTATNPMDGRELPVFTADYVLTGYGTGAIMAVPAEDERDHEFAERFELPVIRTV
QPPEDFTGGAWTGDGITINSASAELDLNGLSQEEAKRRATEFVTHQGFGRARTTYRLRDWLFSRQRYWGEPFPIVYDPAD
PETPIALPESMLPVDLPDVTDFSPKTFDPMDADTEPQTPLSRAGDWVEVELDLGEGPKTYLRETNTMPQWAGSSWYHLRY
IDPTEDDVLVRPENEAYWLGAREDGGAGGVDLYVGGAEHAVLHLLYARFWHKVLFDRGDVSSQEPFQRLFNQGYIQAYAY
TDSRGVHVPAEEVVAEADGTYTYQGEPVTQEYGKMGKSLKNAVAPDDMYEEYGADTLRVYEMSMGPLDLSRPWETRAVVG
SQRFLQRLWRLVVDEETGVLTVSDEPADLATKQAAHRTIDGVARDMDRMHFNTAIAKLIELVNHLTKQLTSTGSTPREAV
EPLVLLVAPLAPHLAEELWARLGHTGSISRVPYPAADPELLKDEQVTCVIQVKGKVRHRIEVDPEISEEDLEAAVMAEPR
VQELLEGQTLRKLIIRAPKIVNIVI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 2e-128 47