Gene Information

Name : Ksed_25620 (Ksed_25620)
Accession : YP_003150289.1
Strain : Kytococcus sedentarius DSM 20547
Genome accession: NC_013169
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 2633925 - 2635349 bp
Length : 1425 bp
Strand : +
Note : PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: mercuric reductase

DNA sequence : 
ATGCCCACGAAGTACGACCTCGCCATCATCGGATCGGGCGGTGGTGCGTTCGCCGCCGCGATCCGCGCGACCACGCTCGG
CAAGTCGGTGGTGATGATCGAGCGCGGGACGCTCGGTGGCACCTGCGTGAACACCGGCTGCGTGCCGTCGAAGGCCCTGA
TCGCCGCGGCCGACGCACGGCACTCCGCGGCCGACGCCGCCGACCGGTTCCCGGGGATCGCGACGACGGCGGGGCCAGTG
GACATGCCCGCCCTGATCGCCGGGAAGCAGGCGCTGGTCGAGTCGCTGCGGGGCGAGAAGTACGCCGACGTCGCCGACTC
CTACGGTTGGGCCGTCCGCCGCGGCGACGCCGCGTTCGCCGGCACCCCCGACGCACCGGTCCTCCAGGTCGCTGGGGACG
ACGGGAGCACCGAGACGATCGAGGCCGGGCACTACCTGGTCGCGACCGGCTCTCGGCCGTGGGCCCCGCCGATCGACGGC
CTGGACCAGACCGGGTACCTGACCTCGACCACGGCGATGGAGCTGACCGAACTCCCTGAGTCCCTGCTCGTGCTCGGCGG
CGGCTACGTCGCCCTGGAGCAGGCGCAGCTGTTCGCCCGGCTCGGCTCCCAGGTCACCGTGCTGGTCCGGTCCCGGCTCG
CGTCGAAGGAGGAGCCGGAGGTGTCCAGGACGCTGCAGGAGGTGTTCGCCGACGAGGGCATCCGGGTGGTCCGCCGCGCG
CTGCCGACGCGGGTGTCCCGCGACGCCGCGACCGGGCAGGCCGTCGTCACCGCGGACGTCGCCGGCGGCCGGGAGGAGTT
CCGCGCCGACCAGGTGCTCGTCGCCCTCGGACGACGACCGGCCACCGATGGGCTCGGCCTCGACAGGGTCGGGGTCAAGA
CCGGGGACCTCGGCGAGGTGGTCGTCTCCGACCGGATGCAGTCCTCCCACCCGCGGATCTGGGCCGCGGGCGACGTGACC
GGCCACCCCGAGTTCGTCTACGTCGCCGCCCACCACGGCACCCTCGTCGCCGAGAACGCGTTCGCCGACGCCGATCGGGC
CGTGGACTACGCCCGACTGCCGAGGGTGACGTTCACCGGCCCGGCGATCGGCGCGGTCGGGATGACCGAGAAGGACGTCG
TCGCCGCCGGGATCCGCTGCGACTGCCGCGTCCTGCCCCTGCACCACGTGCCCCGCGCACTGGTCAACCGCGACACCCGC
GGCTTCGTCAAGATCGTCGTGGACGCCGACACCGGGAAGATCCTCGGCATCACCGCCGTCGCCAAGGACGCCGGCGAGCT
CGCCGCCGCCGGGGTCCACGTGCTCGGCAAGACGGTCGCCGAGGTCGCCGACGCCTGGGCCCCCTACCTGACCATGGCCG
AGGGCATCCGGATCGCCGCCAAGGCCTTCACCACCGACCCGTCGCTCCTGTCGTGCTGCGCGTGA

Protein sequence : 
MPTKYDLAIIGSGGGAFAAAIRATTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAADARHSAADAADRFPGIATTAGPV
DMPALIAGKQALVESLRGEKYADVADSYGWAVRRGDAAFAGTPDAPVLQVAGDDGSTETIEAGHYLVATGSRPWAPPIDG
LDQTGYLTSTTAMELTELPESLLVLGGGYVALEQAQLFARLGSQVTVLVRSRLASKEEPEVSRTLQEVFADEGIRVVRRA
LPTRVSRDAATGQAVVTADVAGGREEFRADQVLVALGRRPATDGLGLDRVGVKTGDLGEVVVSDRMQSSHPRIWAAGDVT
GHPEFVYVAAHHGTLVAENAFADADRAVDYARLPRVTFTGPAIGAVGMTEKDVVAAGIRCDCRVLPLHHVPRALVNRDTR
GFVKIVVDADTGKILGITAVAKDAGELAAAGVHVLGKTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 4e-69 45
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 5e-84 43
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 4e-84 43
merA ABQ57371.1 MerA Not tested SGI1 Protein 2e-68 43
merA AGK07021.1 MerA Not tested SGI1 Protein 2e-68 43
merA AGK07079.1 MerA Not tested SGI1 Protein 2e-68 43
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 2e-67 43
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 5e-66 43
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 3e-66 43
merA AFG30120.1 MerA Not tested PAGI-2 Protein 3e-66 43
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 2e-67 43
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 1e-65 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Ksed_25620 YP_003150289.1 mercuric reductase BAC0651 Protein 3e-84 43
Ksed_25620 YP_003150289.1 mercuric reductase BAC0652 Protein 1e-69 43
Ksed_25620 YP_003150289.1 mercuric reductase BAC0224 Protein 2e-80 43
Ksed_25620 YP_003150289.1 mercuric reductase BAC0653 Protein 4e-65 41