Gene Information

Name : Svir_20860 (Svir_20860)
Accession : YP_003133926.1
Strain : Saccharomonospora viridis DSM 43017
Genome accession: NC_013159
Putative virulence/resistance : Virulence
Product : peptide arylation enzyme
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 2228424 - 2230079 bp
Length : 1656 bp
Strand : -
Note : PFAM: AMP-binding enzyme; TIGRFAM: 2,3-dihydroxybenzoate-AMP ligase

DNA sequence : 
ATGAGTGAGGGGCACGGTCTCGGACCGGACCACGTCGCCTGGCCGCCGGAGGTGGCCGCCCACTACCGCGCGGCCGGATA
CTGGCGGGGACAGACGTTCGGCGCGCTACTGACGTCGTTGACGGCCGCCTACGCCGATCGCACGGCGGTGGTGGGGGAGC
GGAACGGAACGGTGTCGCGGCTGAGCTACGCCGAGCTCGACGACGCCGCGCACCGGATCGCCGCGGGACTGGTCGACCTG
GGGATCAAGGCGGGCGACCGGGTGATCGTGCAGTTGCCGAACATCCCGGAGTTCGTGTCGGTGATCTTCGGTGTGTGGCG
TGCCGGGGCGTGGCCGGTGTTCACGTTGCCCGCACACCGGCACAGCGAACTGCGGCACTTCGCCACACAGAGCGAGGCGG
CGGCCATCATCACCGTCGACCACCACAACCGTCATGACCACGCCACGATGGCCAAGGCCGTCGCGGCCGAAGTGGACTCG
GTGCGACACGTGCTCGTGGTCGGCTCGCAGGAGTTCGCCGACCTCGCCGCGACCCCGCCGCGGGAGTTGCCCGACCCCGA
TCCGGGGTCGGTGGCGTTCCTCCAACTGTCGGGCGGCAGCACCGGACTGCCGAAGCTGATCCCCCGCACGCACGACGACT
ACCTGTACAGCGTGCGGGAGAGCGCTCGGATCTGTGCGTTGCGCCCGGAGAGCGTGTACCTGGCGGTCCTGCCCGCCGCG
CACAACTTCCCGCTCAGTTCGCCCGGGGTGTTGGGGGCCCTGCACGCGGGGGCGACCACCGTCATGTCGCCGAGCCCGGA
CGCGGGCACGGCGTTCCGGCTGATCGAGTCGGAGAAGGTCACGATCACCGGTGTCGTACCGCCGCTGGCCGCGGCATGGG
TGCAGGCCGCCGCGCACACCGACCGTGATCTGTCCAGTTTGCAGGTCATCCTCGTCGGGGGAGCGAAGTGCAGTCGCGAA
CTCGCCGAGCGGATCGGTCCCGCGTTGGGCTGTCAGCTGCAGCAGGTCTTCGGCATGGCCGAGGGATTGGTCTGCTACAC
GCGGCTCGACGACCCCGAACAGATCGTGCTCAGCACCCAGGGACGGCCGATCTCCCCCGACGACGAGATCCGGATCGTCG
ATCCGGACGATCCCGACGCGTCCGCTGAGGACGAGGTGGCGCCGGGAGAGGTGGGCGCCTTGTTGACGCGCGGCCCGTAC
ACCATCCGCGGTTACTACCGCGCTGCCGAACACAACGCCACGGCGTTCACCCCGGACGGTTTCTACCGGACGGGGGACCT
CGTACGGCGGCATCCGTCCGGGCACCTGGAGGTGGTGGGGCGGGTCAAGGAGCAGATCAACCGAGGCGGCGAGAAGGTGG
CGGCCGAGGAGGTCGAGAACCACTTGATGGCTCATCCGGGGGTGCTCGACGCCGCGGTCGTCGCGGTGCCGGACGAGTAC
CTGGGGGAGCGGACCTGCGCCTACGTCATCCCCACCGAGGGGTCCGAGTTGACGGGCGCGGAACTGCGCCGCTTCGTCCG
GGAACGCGGGGTCGCCGCGTTCAAGGTGCCGGACCTGGTCATGGTGGTGGACTCGTTCCCGGTGACCGGGGTCGGCAAGA
CGAGCAAGCGTGAACTCCGAGCGGCGCTCGCGGCGCTCGCCAAGAACGGGGGATAG

Protein sequence : 
MSEGHGLGPDHVAWPPEVAAHYRAAGYWRGQTFGALLTSLTAAYADRTAVVGERNGTVSRLSYAELDDAAHRIAAGLVDL
GIKAGDRVIVQLPNIPEFVSVIFGVWRAGAWPVFTLPAHRHSELRHFATQSEAAAIITVDHHNRHDHATMAKAVAAEVDS
VRHVLVVGSQEFADLAATPPRELPDPDPGSVAFLQLSGGSTGLPKLIPRTHDDYLYSVRESARICALRPESVYLAVLPAA
HNFPLSSPGVLGALHAGATTVMSPSPDAGTAFRLIESEKVTITGVVPPLAAAWVQAAAHTDRDLSSLQVILVGGAKCSRE
LAERIGPALGCQLQQVFGMAEGLVCYTRLDDPEQIVLSTQGRPISPDDEIRIVDPDDPDASAEDEVAPGEVGALLTRGPY
TIRGYYRAAEHNATAFTPDGFYRTGDLVRRHPSGHLEVVGRVKEQINRGGEKVAAEEVENHLMAHPGVLDAAVVAVPDEY
LGERTCAYVIPTEGSELTGAELRRFVRERGVAAFKVPDLVMVVDSFPVTGVGKTSKRELRAALAALAKNGG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-99 48
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-99 48
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 5e-99 48
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-99 48
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-99 48
ybtE CAA21394.1 - Virulence HPI Protein 5e-99 48
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 4e-99 48
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 5e-98 47
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-98 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Svir_20860 YP_003133926.1 peptide arylation enzyme VFG0168 Protein 5e-109 49
Svir_20860 YP_003133926.1 peptide arylation enzyme VFG1817 Protein 8e-101 48
Svir_20860 YP_003133926.1 peptide arylation enzyme VFG0932 Protein 2e-104 45