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Name : vanB (Caci_5793) Accession : YP_003116492.1 Strain : Catenulispora acidiphila DSM 44928 Genome accession: NC_013131 Putative virulence/resistance : Resistance Product : D-alanine--D-lactate ligase Function : - COG functional category : M : Cell wall/membrane/envelope biogenesis COG ID : COG1181 EC number : 6.3.2.4 Position : 6693075 - 6694115 bp Length : 1041 bp Strand : - Note : vancomycin B-type resistance protein; catalyzes the formation of D-alanyl-D-lactate in peptidoglycan synthesis DNA sequence : ATGGATAAGCTCAATATCGGCATCATGTTCGGCGGCTGCTCGGAGGAACACCCCATCTCTGTCAAGTCCGCACGGGAGGT CGCGAAGAACCTCGACACCAGCAAGTACGAACCCTTCTACATCGGCATCACTCGGGACGGCGCGTGGCGACTGTGCGACG GCCCAGAGGAGAACTGGGAGAACGGCGCGAGCCGTCCCGCCGTGGTGTCGCCGGACCGAGGCGCGCACGGACTGCTCGTC CTGGACCAGGGACGCTACGAAGCGATCCGCCTGGACCTGGTCCTGCCGGTCCTGCACGGCAAGCTCGGCGAGGACGGCGC GATCCAGGGTCTGCTGGAGCTGGCCGGCATCCCCTACGTGGGCTGCGACGTACAGACCTCCGTCCTGTGCATCGACAAGA CGCTCACTTACCTCGTCATACAGAACGAGGGGATCGCGACGCCGAGGTTCTGGACCCTCACGCCCGACGAGAAGATCGAT CCGAACGAGCTGCCCTATCCGGTATTCGTCAAGCCGGCTCGCTCGGGGTCTTCGTTCGGCGTCAGCAAGGTGTCCGGCAA GGACGAGCTGTCCGGCGCCATCGAGGAGGCGCGGCTGTATGACGCCAAGGTGCTCATCGAGGAGGCGGTCGTCGGCAGCG AGATCGGCTGCGCGGTCCTGGGCACCGGCGAGGATCTGCTCGTCGGCGAGGTGGACCGGGTCGCGCTGACCCACGGCTTC TTCAAGATTCACCAGGAGAGCGCGCCGGAGACCGGTTCGGAGAACGCGACGTTCATCGTCCCCGCCGACATCCCGGCGCA GTCGCGCGCACTGATTCAGGAGACTGCGAAGCTCGTCTACCGCGCTCTGGGTTGCCGCGGGCTGTCGCGGGTCGACTTCT TCCTGAAGGAGGACGGGACCGTGGTCCTCAACGAGGTCAACACGCTCCCCGGCCTGACCTCCTACAGCCGCTACCCGCGG ATGATGGCGGCCGCCGGATTCCCGATGTCCGAGGTCATCGACCGGTTGGTGGCGGTGACGATCGCGGGGGACCTCCGGTG A Protein sequence : MDKLNIGIMFGGCSEEHPISVKSAREVAKNLDTSKYEPFYIGITRDGAWRLCDGPEENWENGASRPAVVSPDRGAHGLLV LDQGRYEAIRLDLVLPVLHGKLGEDGAIQGLLELAGIPYVGCDVQTSVLCIDKTLTYLVIQNEGIATPRFWTLTPDEKID PNELPYPVFVKPARSGSSFGVSKVSGKDELSGAIEEARLYDAKVLIEEAVVGSEIGCAVLGTGEDLLVGEVDRVALTHGF FKIHQESAPETGSENATFIVPADIPAQSRALIQETAKLVYRALGCRGLSRVDFFLKEDGTVVLNEVNTLPGLTSYSRYPR MMAAAGFPMSEVIDRLVAVTIAGDLR |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| vanB | NP_815951.1 | D-alanine--D-lactate ligase | Not tested | Not named | Protein | 8e-102 | 61 |
| vanB | YP_008394259.1 | Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase | Not tested | Not named | Protein | 4e-102 | 60 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | AF277571.gene.p01 | Protein | 1e-108 | 63 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | AY489045.gene.p01 | Protein | 5e-105 | 62 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | AE016830.1.gene2250. | Protein | 4e-102 | 61 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | U00456.gene.p01 | Protein | 4e-102 | 61 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | U35369.1.gene6.p01 | Protein | 4e-102 | 61 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | AY145441.gene.p01 | Protein | 4e-102 | 61 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | AF310956.2.orf5.gene | Protein | 3e-102 | 61 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | AF130997.1.orf4.gene | Protein | 3e-106 | 61 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | NC_005054.2598280.p0 | Protein | 1e-101 | 60 |
| vanB | YP_003116492.1 | D-alanine--D-lactate ligase | NC_014475.1.orf3.gen | Protein | 1e-101 | 60 |
