Gene Information

Name : lysS (Amir_0906)
Accession : YP_003098712.1
Strain : Actinosynnema mirum DSM 43827
Genome accession: NC_013093
Putative virulence/resistance : Unknown
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 995843 - 999127 bp
Length : 3285 bp
Strand : +
Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
GTGGCGGTTGCCGGGTGGAAGTGGCGGGCGGCGGGGGTCGTCGCCACGGTCGTGCAGGTCTCCGCGCTGGCCTCCCTGGT
GCTGCTGCTGTGGGCCGAGGGCACGACCCTCGGCGACGTCATCTTCTTCTCCGGCTACGCCCTCGGCCTGCCGGTCGAGG
CGAACCTGTTCATCGTCCTGGTCCTGGTGGTCCTCGGCGCGGCGCTGCGCGCCCGCAAGCGCGCGGCCCTGTGGGCCCTG
CTGCTCACCGAGGCGCTCGGCCTCGCCTGGAACCTGGCCGTGCTGCTCCTGCTCGCCGTCGCCCCCGACGTGCCGGCGTC
GGGGGAGCAGGTGGACTGGCGGCGCGCGCTGGGCTTCCTGGGCGGCGGCGCCCTCACCGCCCTGGTCATCATCGCCTTCC
TGCTGGCGATCCGGGAGGCGTTCCCCGCCGAGCTGGCCCCCGGCGCCTGGCGCAAGGCGCTGGCCGCGTTCATCGTCGGC
CTCGCCGCCGCCGCCACCGCCGGGTTCCTGCTCACCGAGGTCTTCCCCGGCTCCCTCCGCGACCAGGGCGAGATGCTGGT
CTGGGCGGCCAACCAGGTCTCCGGCGAGGTGGTGCCGCTGCGCCGCGCCCTGTCCGGCGAGGGCCCGGCCTGGCTGAGCG
TGCTGCTCGGCGTCACCGGCACGCTCGTCGCGATCTTCGCCCTGTACCTGTTCTTCCGGGGCGAGCGCTCCAGCCGGTGG
ATCAACGTCGACGAGGAGCTCACCCTGCGCCGCCTGCTGGCCGCCCACGGCGAGCCGGACTCGCTCGGCTACTTCGCCAC
CCGCCGCGACAAGAGCGCCGTGCTCTCCCCGGACGGCCGCGCCGCGCTGACCTACCGGGTGCTCGCGGGCACCACCCTGG
CCAGCGGCGACCCGGTCGGCGACGAGGACTCCTGGCGGCAGGCGGTGCGGGCCTGGCTCGACGAGGCCCGCCGGTACGGC
TGGCGCGCGGGCGTCCTCGGGGCCAGCGAGCGCGGCGCCCGCGCCTACGCGGCCGAGGGCCTCAAGGCGCTGGAGATCGG
CGACGAGGCCGTGCTGGACGTGCGCGAGTTCAGCCTCGCCGGACCGGAGCGGCGCGCGGTCCGGCAGGCGGTCAGCCGAG
TGGAGCGCGCCGGGTACACCGCGCGGGTGCGCAGGCACGCCGAGATCCCCGCCGACGAGATGGCCGGGCTGCTCGACCTG
GCCCAGCGGTGGCGCGGCGCGCAGACCGAGCGCGGCTTCTCCATGGCGCTCGGCAGGCTCGGCGACGAGTCCGACGGCCG
GTGCGCGATGGTCGAGGCCTACGACGCGGACGGCGCGCTGCGCGGGCTGCTCTCGTTCGTGCCGTGGGGCAGGCGCGGGC
TGTCCCTCGACCTGATGCGGCGCGACCGGACCGCCGAGAACGGGCTCAACGAGTTCATGGTCGCCGAGCTGGTCGCCGCC
GCCGGACGGCTGGGCGTGCAGCGGGTGTCGCTGAACTTCGCCATGTTCCGCGCGGTGTTCGAGGAGGGCGAGAAGCTCGG
GGCCGGACCGGTGCTGCGGGCCTGGCGCGGCGTCCTCGGCCTGGCCTCCCGGTTCCTGCAGCTGGAGTCCCTGTACCGCT
CCAACGCCAAGTACGGCCCCGACTGGCAGCCCCGCTACCTCTGCTACTCGGGCGTGCGGAGCCTGCCGAGGGTGAGCGTC
GCGGCGGGCGTCGCCGAGGGCTTCGTGCCGAACCTGCGCTCCCTGCTCAAGCGCGGCTCCCGCCGCCGGGGCCTGGACGG
GGCCACCACGTCCGGCCGCTGGTTCGCCGACGCCGTCCGCGAGATCGAGGCCACCCGCCCCGAACCGGCCCGCGCCCGCC
GCCCCGAGCAGGTCAGGGTCCGCATGGCCAAGCTCGACCTGCTGCGCGCCGCGGGCCGCGACCCGTACCCCGTCGGCTAC
GACCGCGACTGCCCCGTCGCCGAGGTCGAGTCCCGGTTCGGGCAGGTCGTCGCGATCACCGGCCGGGTCGTGGCGCTGCG
CGAGCTGGGCGGCCTGTGCTTCGCCCGCGTCCGCGACTGGACCGGCGAGGTGCAGGTCATGCTGGACGCCGCCACCACCG
AGGACCTGCACCTGTGGAAGTCCGGCGTCGACCTGGGCGACCACGTCGGCGCGCGCGGCGAGGTCGTGCGCTCCCGGCGC
GGCGAGCTGTCCGTGCTGGTCGCCGACTGGGCGATCACCGCCAAGTGCCTGCACCCGCTGCCCGACCGCCGCGCGGGCCT
GGCCGACCCGGAGGCGCGGGTCCGCAAGCGCTACCTGGACCTGGCGGTCAACCCCGACTCGGCCGCGATGCTGCGCACCC
GCAGCGCCGTCGTGCGCGCCGTCCGGGACTTCCTGCACGACCGGGGCTACCTGGAGGTCGAGACCCCGATGCTCCAGACC
GTGCACGGCGGGGCCAACGCGCGGCCGTTCGTCACCCACATCAACGCCTACGACACCCGCATGTACCTGCGGATCGCGCC
CGAGCTGTACCTGAAGCGGTTGTGCGTGGCGGGCGTGGACCGGGTGTTCGAGCTGAACCGGAACTTCCGCAACGAGGGCG
CCGACGCCACCCACAACCCGGAGTTCACCATGCTGGAGGCGTACCAGGCGTACGCCGACTACCGGGTGATGCTGGACCTG
GTGCGGGAGCTGGTGCAGCACGCCGCGGTGGCCGCGCACGGCAGGCAGGTCGCGGTCCGCGACGGCGCGGAGGTCGACAT
CTCGGGTGAGTGGCCGGTGGTGCCGGTGCACGCGGCCGTGTCCACCGCGCTCGGCGTGCAGGTCGGCCCGGACCTGCCGC
TGGACGAGCTGCGCGCCGCGCTGGTCGCCGGGGGCGTGCCGCTGCCGGAGGACCTGGAGGCCGACCACGGGACGCTGGTG
CTGCGCGCCTACGACCACCTCGTGGAGCCCGCCACGACCGCCCCGACCTTCTACACCGACTTCCCCACCTCGGTGTCCCC
GCTGACCAGGGAGCACCGCGCCGACCCCCGGCTGGCCGAGCGCTGGGACCTGGTCGCGTTCGGCGCGGAGGTCGGCACCG
CCTACTCCGAGCTGACCGACCCGGTCGAGCAGCGCCGCAGGCTGGAGGCCCAGTCGCTCAAGGCCGCCAGCGGCGACGTC
GAGGCGATGGAGCTGGACGAGGACTTCCTGGCCGCGCTGGAGCACGGCATGGCCCCCACCGGCGGCCTTGGCCTGGGCGT
GGACCGCCTGCTGATGATGCTCACCGGGGCGAGCATCCGGCAGACGGTCCTGTTCCCGTTCGTCCGCCCCGGGCCGAAGT
CCTGA

Protein sequence :
MAVAGWKWRAAGVVATVVQVSALASLVLLLWAEGTTLGDVIFFSGYALGLPVEANLFIVLVLVVLGAALRARKRAALWAL
LLTEALGLAWNLAVLLLLAVAPDVPASGEQVDWRRALGFLGGGALTALVIIAFLLAIREAFPAELAPGAWRKALAAFIVG
LAAAATAGFLLTEVFPGSLRDQGEMLVWAANQVSGEVVPLRRALSGEGPAWLSVLLGVTGTLVAIFALYLFFRGERSSRW
INVDEELTLRRLLAAHGEPDSLGYFATRRDKSAVLSPDGRAALTYRVLAGTTLASGDPVGDEDSWRQAVRAWLDEARRYG
WRAGVLGASERGARAYAAEGLKALEIGDEAVLDVREFSLAGPERRAVRQAVSRVERAGYTARVRRHAEIPADEMAGLLDL
AQRWRGAQTERGFSMALGRLGDESDGRCAMVEAYDADGALRGLLSFVPWGRRGLSLDLMRRDRTAENGLNEFMVAELVAA
AGRLGVQRVSLNFAMFRAVFEEGEKLGAGPVLRAWRGVLGLASRFLQLESLYRSNAKYGPDWQPRYLCYSGVRSLPRVSV
AAGVAEGFVPNLRSLLKRGSRRRGLDGATTSGRWFADAVREIEATRPEPARARRPEQVRVRMAKLDLLRAAGRDPYPVGY
DRDCPVAEVESRFGQVVAITGRVVALRELGGLCFARVRDWTGEVQVMLDAATTEDLHLWKSGVDLGDHVGARGEVVRSRR
GELSVLVADWAITAKCLHPLPDRRAGLADPEARVRKRYLDLAVNPDSAAMLRTRSAVVRAVRDFLHDRGYLEVETPMLQT
VHGGANARPFVTHINAYDTRMYLRIAPELYLKRLCVAGVDRVFELNRNFRNEGADATHNPEFTMLEAYQAYADYRVMLDL
VRELVQHAAVAAHGRQVAVRDGAEVDISGEWPVVPVHAAVSTALGVQVGPDLPLDELRAALVAGGVPLPEDLEADHGTLV
LRAYDHLVEPATTAPTFYTDFPTSVSPLTREHRADPRLAERWDLVAFGAEVGTAYSELTDPVEQRRRLEAQSLKAASGDV
EAMELDEDFLAALEHGMAPTGGLGLGVDRLLMMLTGASIRQTVLFPFVRPGPKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 3e-161 45
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 1e-161 45
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 1e-161 45
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 1e-161 45