Gene Information

Name : Amir_2726 (Amir_2726)
Accession : YP_003100506.1
Strain : Actinosynnema mirum DSM 43827
Genome accession: NC_013093
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 3136848 - 3138524 bp
Length : 1677 bp
Strand : -
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: scl:sce3880 (2,3-dihydroxybenzoyl)adenylate synthase

DNA sequence : 
ATGAGCGCCGATCCGAGCACCACGAACCCCACCGGGCGGGGGCACCAGCGCGACCACGCCCCGTGGCCGCCGGAGTTCGT
CGAGCGGTACCGGGACGCCGGGCACTGGACCGGGCGGACGTTCGGGGCCCTGCTGGCGGACACCGCGCGCGAGCACCCGA
CCCGCACCGCCGTCGTCGGCGAGCGGGACGGCGTCACCTCGCGGTGGTCGTACGCGGAGCTGGACGAGCGGGCGCACCGG
GTCGCCGCCGGGCTCGTCGCGCGCGGCATCGGGGCCGGGGACCGGGTGGTGCTGCAACTGCCGAACATCCCCGAGTTCCT
GCCGGTGGTGTTCGGGCTGTGGCGGGCGGGCGCGTGGCCGGTGTTCGCGCTGCCCGCGCACCGGCAGAGCGAGCTGACGC
ACTTCGCGCGCCAGTCCGAGGCCGTCGCGATCATCACCACCGGCGTGCACGAGCGGCACGACCACGCGGCCACCGCGCGG
GCGGTCGCGGCCGAGGTGGCCTCGGTGCGGGACGTGCTCGTGGTGGGCACGCCCGAGTTCACCGACCTGGCCGCGACGCC
GCCGCGCGAGCTGCCCGAGCCCGATCCGGGGAGCGTGGCGTTCCTCCAGCTCTCCGGCGGCAGCACGGGACTGCCGAAGC
TGATCCCGCGCACCCACGACGACTACCTGTACAGCGTCCGGGAGAGCGCGCGGATCTGCGAGCTGACCGAGGAGAGCGTG
TACCTGGTCGCGCTGCCGGTCGCGCACAACTACCCGATGAGCAGCCCCGGAATCCTCGGCGCGGTCCACGCAGGCGCGAG
GATCGTGCTGGCCCCGCGCCCGGACGCGGACACCGCGTTCCGGCTGATCGAGGCCGAGGGCGTCACGATCACCGGCGTGG
TGCCGCCGCTGGCCGCCGCGTGGACCCAGGCCGCCGCCCGCACCGACCGCGACCTGTCCACCCTGGACGTCCTGCTGGTC
GGCGGCGCGAAGTGCGGCCGGGAGCTGGCCGCGCGGATCGGGCCCGCGCTGGGCTGCCGGTTGCAGCAGGTGTTCGGCAT
GGCCGAGGGCCTGGTCTGCTACACCCGGCTGGACGAGCCGCAGGAGCTGGCGCTCACCACGCAGGGCCGCCCGATGTCCG
AGGACGACGAGGTGCGCGTGGTCGACCCGGACGACCCGGCCGCGCCCTCGCACGCCGAGGTGGCGCCGGGCGAGGTGGGC
GCGCTGCTCACCAGGGGGCCTTACACGATCCGGGGCTACTACCGGGCCGACGCGCACAACGCGACCGCGTTCACCGAGGA
CGGCTTCTACCGGACCGGGGACCTGGTGCGGCGCCTGCCGTCCGGGCACCTGGAGGTGGTGGGCCGGGCCAAGGAGCAGA
TCAACCGGGGCGGGGAGAAGGTCGCCGCCGAGGAGGTCGAGGACCACCTGATGGCGCACCCGCTGGTGCTGGACGCGGCG
GTGGTCGCGGTGCCGGACGCCTACCTGGGCGAGCGGACCTGCGCCTACGTGGTGCCGGTGCCGGGCGGCGAGGAGCCGAC
CGGGCCGCAGCTGCGCCGGTTCGTGCGCGAGCGGGGCGTGGCCGCGTTCAAGGTGCCGGACCTGGTGCGGGTGGTGCCGG
AGTTCCCCGTGACCGGGGTGGGCAAGACGAGCAAGCGGGAACTGCGCGCGGCGCTGGCCGCCGCCGAGGAGGGGTGA

Protein sequence : 
MSADPSTTNPTGRGHQRDHAPWPPEFVERYRDAGHWTGRTFGALLADTAREHPTRTAVVGERDGVTSRWSYAELDERAHR
VAAGLVARGIGAGDRVVLQLPNIPEFLPVVFGLWRAGAWPVFALPAHRQSELTHFARQSEAVAIITTGVHERHDHAATAR
AVAAEVASVRDVLVVGTPEFTDLAATPPRELPEPDPGSVAFLQLSGGSTGLPKLIPRTHDDYLYSVRESARICELTEESV
YLVALPVAHNYPMSSPGILGAVHAGARIVLAPRPDADTAFRLIEAEGVTITGVVPPLAAAWTQAAARTDRDLSTLDVLLV
GGAKCGRELAARIGPALGCRLQQVFGMAEGLVCYTRLDEPQELALTTQGRPMSEDDEVRVVDPDDPAAPSHAEVAPGEVG
ALLTRGPYTIRGYYRADAHNATAFTEDGFYRTGDLVRRLPSGHLEVVGRAKEQINRGGEKVAAEEVEDHLMAHPLVLDAA
VVAVPDAYLGERTCAYVVPVPGGEEPTGPQLRRFVRERGVAAFKVPDLVRVVPEFPVTGVGKTSKRELRAALAAAEEG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-79 45
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-79 45
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-79 45
ybtE CAA21394.1 - Virulence HPI Protein 1e-79 45
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-80 45
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-79 45
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-80 45
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 2e-79 45
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-79 45

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Amir_2726 YP_003100506.1 AMP-dependent synthetase and ligase VFG0168 Protein 4e-100 48
Amir_2726 YP_003100506.1 AMP-dependent synthetase and ligase VFG1817 Protein 2e-82 46
Amir_2726 YP_003100506.1 AMP-dependent synthetase and ligase VFG0932 Protein 4e-84 43