Gene Information

Name : guaA (FIC_00556)
Accession : YP_003095076.1
Strain : Flavobacteriaceae bacterium 3519-10
Genome accession: NC_013062
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 570191 - 571720 bp
Length : 1530 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAGCACGGCATCATCATTCTCGATTTTGGATCCCAGTATAACCAGCTCATCGCACGCAGAATCCGCGAACTCGGCGT
GTACTCAGAAGTTTTGCCTTTCGATACTTCGCTGGATGAAATCCTCTCCAGAAAACCTTCGGGAATCATTCTTTCAGGCG
GGCCAAGCTCCGTAAATATTGAAAACGCGAGACTTGTTGACAGGCAACTGTTTGAAAATAACATTCCTGTCCTCGGGATC
TGCTACGGAATGCAGCTCATCACGCACCTGCTGGGTGGCAAAGTGAAAAAAGGCGACAAAGGCGAGTATGGAAAAGCCAA
ACTCGAGATTCTGAAAGGAAACGCGCTTCTGTCGGGCATCAGCCGCTATTCTACTGTTTGGATGAGCCATTTCGATGAGG
TGCAGGAGTTACCCGCAGGATTCGTTACAAATGCAGTTTCGGATGTTATTTCGGCAATTTCAAATGAAGCTCAGAAGATT
TACGGCGTTCAGTTTCACCCAGAAGTTTCGCACACCGAAGAAGGAGCACGCATGATCGAGAATTTCGTGTTCGGAATCTC
TAATGCGCCCAAAAACTGGAAACTCACAAATTATATCGATAAGACTGTAGCCGAAATTAAAGAAAAAGTAGGGCAGCATA
AAGTTATTTTAGGCCTTTCTGGTGGAGTAGATTCGTCCGTGGCGGCGGTTTTGATTCACCGTGCTATTGGTGATCAGCTG
CAGTGCATTTTCGTTGATACCGGACTTCTACGAAAAGAAGAAGCCGAAAAAGTAATGAAGAATTACGGCGAACACTTCAA
ACTTAAAATCAAACTCATCGATGCAAAAGACAGGTTTCTGTCTAAGCTGAAAGGTATCTCAGATCCCGAAGAAAAGCGGA
AAATAATCGGAAACGAATTTGTGGTGGTTTTCGATGAAGAATCTCATAAAATTGAAGGCGCAAAATTCCTGGCTCAGGGC
ACAATTTATCCGGATGTTATCGAAAGCCAGTCGGTTAAAGGTCCATCCGCGGTGATAAAATCTCACCATAATGTGGGCGG
CCTTCCGGCAGAAATGGATTTCGAACTTCTCGAGCCACTGCGCGAACTCTTCAAAGATGAGGTGAGGAAAGTAGGCGAGG
AGCTTGGTATTCCGCATCATTTAGTGCACAGACATCCGTTTCCGGGCCCTGGACTAGGCATAAGAATCCTGGGCGAAGTT
GATAACGAAAAAGTACAGATTCTTCAGCATGCAGACGATATCTTTATTGAAGAACTTTACAAAAACAAACTTTACGAAAC
AGTGTCCCAGGCTTTCGTGGTTTTACTTCCGGTGAAATCTGTAGGAGTGATGGGCGACGAACGGACTTACGAATATACTG
CGGTGGTGCGTTCAGCGAACACGACCGACTTCATGACGGCTACATTCAGCAGGTTTCCGTGGGAATTTCTGGAGACCGTT
TCTAACCGGATCATCAATGAAGTGCGCGGTATCAACCGTGTGGCGTATGACATCTCGAGCAAACCGCCCGCTACGATTGA
GTGGGAATAG

Protein sequence :
MQHGIIILDFGSQYNQLIARRIRELGVYSEVLPFDTSLDEILSRKPSGIILSGGPSSVNIENARLVDRQLFENNIPVLGI
CYGMQLITHLLGGKVKKGDKGEYGKAKLEILKGNALLSGISRYSTVWMSHFDEVQELPAGFVTNAVSDVISAISNEAQKI
YGVQFHPEVSHTEEGARMIENFVFGISNAPKNWKLTNYIDKTVAEIKEKVGQHKVILGLSGGVDSSVAAVLIHRAIGDQL
QCIFVDTGLLRKEEAEKVMKNYGEHFKLKIKLIDAKDRFLSKLKGISDPEEKRKIIGNEFVVVFDEESHKIEGAKFLAQG
TIYPDVIESQSVKGPSAVIKSHHNVGGLPAEMDFELLEPLRELFKDEVRKVGEELGIPHHLVHRHPFPGPGLGIRILGEV
DNEKVQILQHADDIFIEELYKNKLYETVSQAFVVLLPVKSVGVMGDERTYEYTAVVRSANTTDFMTATFSRFPWEFLETV
SNRIINEVRGINRVAYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-127 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-127 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-127 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-104 47