Gene Information

Name : thyA (NMO_1523)
Accession : YP_003083677.1
Strain : Neisseria meningitidis alpha14
Genome accession: NC_013016
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1634635 - 1635429 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAAGCCTATTTGGACTTGATGCGCCACGTCCTCGACAACGGTACGGACAAATCAGACCGCACCGGTACGGGCACGCG
CTCCGTATTCGGTTATCAGATGCGTTTTGACTTGGGCAAAGGTTTTCCGCTGCTGACGACCAAAAAGCTGCATCTGCGTT
CGATTATCCACGAGCTGCTTTGGTTTCTCAAAGGCGATACCAATATCAAATACCTGAAGGACAACAATGTTTCCATTTGG
GACGAGTGGGCGGACGAAAACGGCGACTTGGGCCCGGTTTACGGCTACCAGTGGCGCAACTGGCCCGCGCCCGACGGCCG
CCATATCGACCAAATCGCCAATGTGGTGGAACAAATTAAGAAAAACCCCGACTCGCGCCGCCTGATTGTATCGGCGTGGA
ATCCGGCTTTGGTCGATGAGATGGCCTTGCCGCCTTGCCACGCGCTGTTTCAGTTTTACGTTGCCGACGGCAAACTGTCC
TGCCAGCTTTACCAGCGTAGTGCGGATATTTTCCTTGGCGTACCGTTCAACATCGCCAGCTACGCATTGTTGACCATGAT
GATGGCGCAAGTGTGCGGATTGGAAGCCGGTGAGTTTATCCATACGTTTGGCGACGCGCATTTGTACCGCAACCATTTCG
AGCAGGCAGAGTTGCAATTGGAACGCGAACCGCGCACCTTGCCTGTGATGAAAATCAATCCTGAAGTCAAAGATTTGTTT
TCCTTCAAGTTTGAAGATTTCGAGTTGGAAGGCTACGACCCCCATCCGCACATCAAGGCGGCAGTGTCGGTCTGA

Protein sequence :
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIW
DEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLS
CQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFIHTFGDAHLYRNHFEQAELQLEREPRTLPVMKINPEVKDLF
SFKFEDFELEGYDPHPHIKAAVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 7e-83 65