Gene Information

Name : epaS (ECSP_3819)
Accession : YP_003079641.1
Strain : Escherichia coli TW14359
Genome accession: NC_013008
Putative virulence/resistance : Virulence
Product : surface presentation of antigens protein SpaS
Function : -
COG functional category : N : Cell motility
COG ID : COG1377
EC number : -
Position : 3781958 - 3783079 bp
Length : 1122 bp
Strand : -
Note : Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins

DNA sequence :
ATGGCAAATAAAACTGAAAAGCCAACACAAAAGAAACTGCAGGATGCTTCTAAAAAAGGGCAAATTCTAAAAAGTAGAGA
CTTAACCGTTTCTGTAATAATGCTTGTGGGTACTTTATATCTCGGATATGTTTTTGATGTGCATCACATTATGTCGATTC
TTGAATATATCCTTGATCATAACGCTAAACCGGATATTTGGGACTATTTTAAAGCTATGGGGATTGGTTGGTTGAAAACG
ATCATTCCTTTTTTGCTGGTTTGCATGTTCACAACAATACTTGTCTCCTGGTTTCAAAGTAAAATGCAATTAGCAACTGA
AGCTGTAAAATTAAAGTTTGATTCATTGAATCCAGTAAATGGTTTAAAGCGTATATTTGGCTTAAAAACCGTAAAAGAAT
TTGTTAAAGCAATTCTTTATATTATTTTTTTTGCATTGGAGATCAAAGTATTTTGGAGTAATCATAAATCACTGCTTTTT
AAAACTCTTGATGGAGATATCATATCTTTATTATCAGATTGGGGAGAGATGCTATTCCTTCTCATACTGTATTGTCTCGG
CAGTATGATAATTGTCTTAATTTTTGATTTTATCGCTGAATATTTTTTATTTATGAAAGATATGAAAATGGATAAACAAG
AAGTTAAAAGAGAATACAAGGAACAAGAAGGAAATCCTGAAATTAAGTCTAAACGCAGAGAGCGCCATCAGGAAATTCTT
TCTGAGCAATTGAAATCTGATGTCAGTAATAGCCGTTTGATGATTGCCAACCCTACTCACATTGCAATAGGGATATACTT
TAAGCCACATCTGTCACCTATTCCATTGATTTCTGTAAGAGAAACTAATGAGGTAGCATTAGCTGTAAGGAAATATGCAA
AGGAAATCGGGATACCAATTATTACAGATAAAAAATTAGCACGAAAAATTTATGCTACCCATCGTCGCTACGATTATGTT
AGCTTCGAAAATATAGATGAAATATTACGTCTTCTGCTGTGGCTTGAAGATGTGGAGAATGCTGGACAACCTGTTCCAGA
TGAACAGCTCTCTTCAGAAGATAAATATATTGAGGGTGAAGACACAAAAAGCGAGAATAATGACAATAATTTAAAAAATT
AA

Protein sequence :
MANKTEKPTQKKLQDASKKGQILKSRDLTVSVIMLVGTLYLGYVFDVHHIMSILEYILDHNAKPDIWDYFKAMGIGWLKT
IIPFLLVCMFTTILVSWFQSKMQLATEAVKLKFDSLNPVNGLKRIFGLKTVKEFVKAILYIIFFALEIKVFWSNHKSLLF
KTLDGDIISLLSDWGEMLFLLILYCLGSMIIVLIFDFIAEYFLFMKDMKMDKQEVKREYKEQEGNPEIKSKRRERHQEIL
SEQLKSDVSNSRLMIANPTHIAIGIYFKPHLSPIPLISVRETNEVALAVRKYAKEIGIPIITDKKLARKIYATHRRYDYV
SFENIDEILRLLLWLEDVENAGQPVPDEQLSSEDKYIEGEDTKSENNDNNLKN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ECs3721 NP_311748.1 surface presentation of antigens protein SpaS Not tested LIM Protein 1e-174 100
spaS NP_461808.1 surface presentation of antigens protein SpaS Virulence SPI-1 Protein 5e-81 55
spaS YP_217806.1 surface presentation of antigens protein SpaS Virulence SPI-1 Protein 8e-80 54
spaS NP_457281.1 secretory protein (associated with virulence) Virulence SPI-1 Protein 7e-81 54
spaS NP_806490.1 surface presentation of antigens protein SpaS Virulence SPI-1 Protein 7e-81 54
spaS AAS66868.1 SpaS Not tested SSR-2 Protein 9e-73 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
epaS YP_003079641.1 surface presentation of antigens protein SpaS VFG0548 Protein 2e-81 55
epaS YP_003079641.1 surface presentation of antigens protein SpaS VFG1015 Protein 1e-75 53
epaS YP_003079641.1 surface presentation of antigens protein SpaS VFG2452 Protein 4e-65 42