Gene Information

Name : ldhA (METDI5391)
Accession : YP_003070813.1
Strain : Methylobacterium extorquens DM4
Genome accession: NC_012988
Putative virulence/resistance : Resistance
Product : fermentative D-lactate dehydrogenase, NAD-dependent
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1052
EC number : 1.1.1.28
Position : 5337583 - 5338593 bp
Length : 1011 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9025293; Product type e : enzyme

DNA sequence : 
ATGGACGTCACGATCTTCAGCACCAAGGCCTACGACCGGCGGTTCCTGGACGGGGCCAACGTGGCGGCGGGAGAGCCGCA
CCGGCTGCGCTATCTCGAAGCCCGGTTGACCCATGAGAGCGCGCCGCTGACGCAGGGAGCGCAGGCCGTGTGCGCTTTCG
TCAACGACGTGCTCGACCGGCCCGTTCTGGAAGTGCTGGCCGCCTCCGGCACGCGGATGGTGGCCCTGCGCAGCGCCGGC
TTCAACAATGTCGATCTTCCCGCCGCCGCGGAACTCGGCATCGCGGTCGGCCGCGTCCCGGCCTATTCGCCGGACGCGGT
CGCCGAGCATACGGTGGCTCTGATCCTCGCGCTCAATCGCAAGACCCACCGGGCCTATGCCCGCGTCCGCGAGGGAAACT
TCGCGCTCGAGGGGTTGCTGGGCTTCGATCTCAAGGGACGCACGGTCGGCATCGTCGGAACCGGCAAGATCGGTCGCGCG
GTCGCGCGCATCCTCGCCGGCTTCGGCTGCCGCGTGCTGGCCTACGACCCCATGCCCTCGGCTGAACTCGCCGGCTTCGG
CGCGGAGGCGGTCGGCCTCGACCGGCTTCTGGCCGAGGCGGACATCGTCTCCCTGCACTGCCCGCTGACGCCCGACACGC
ATCACATGATCGACCGTGCCGCGCTGGCGCGGATGAAGCGCGGCGTGATGCTGATCAATACGGGGCGCGGGGCGCTCGTC
GATACCGCGGCGCTGATCGAGGGTTTGAAATCAGGGGTGATCGGCGATCTCGGCCTCGACGTCTACGAGGAGGAAGGCGG
CCTCTTCTTCGAGGATCTGTCGAACCAGATCATCCGGGACGACGTCTTCTCGCGCCTGCTGACCTTCCCGAACGTGATCG
TGACGGGGCATCAGGCCTTCTTCACCGCCGAGGCGCTGGCGGCGATTGCCGCGACCACCATCGAGAACCTGTCCTGCTTC
GAAAAGCAAGGCGTTCCGCGGCATCCCGTATCGGTCGAGCGCCTCGCCTGA

Protein sequence : 
MDVTIFSTKAYDRRFLDGANVAAGEPHRLRYLEARLTHESAPLTQGAQAVCAFVNDVLDRPVLEVLAASGTRMVALRSAG
FNNVDLPAAAELGIAVGRVPAYSPDAVAEHTVALILALNRKTHRAYARVREGNFALEGLLGFDLKGRTVGIVGTGKIGRA
VARILAGFGCRVLAYDPMPSAELAGFGAEAVGLDRLLAEADIVSLHCPLTPDTHHMIDRAALARMKRGVMLINTGRGALV
DTAALIEGLKSGVIGDLGLDVYEEEGGLFFEDLSNQIIRDDVFSRLLTFPNVIVTGHQAFFTAEALAAIAATTIENLSCF
EKQGVPRHPVSVERLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF2295 NP_815952.1 D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 1e-39 43
vanHB YP_008394258.1 VanH protein, D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 2e-38 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent NC_014475.1.orf2.gen Protein 5e-37 44
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent NC_005054.2598279.p0 Protein 5e-37 44
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent U35369.1.gene5.p01 Protein 2e-40 43
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent AF130997.1.orf3.gene Protein 5e-43 42
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent AF310956.2.orf4.gene Protein 4e-39 42
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent AF155139.2.orf4.gene Protein 1e-39 41
ldhA YP_003070813.1 fermentative D-lactate dehydrogenase, NAD-dependent FJ349556.1.orf3.gene Protein 1e-36 41