Gene Information

Name : metB (METDI4488)
Accession : YP_003069943.1
Strain : Methylobacterium extorquens DM4
Genome accession: NC_012988
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase, PLP-dependent
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 4394623 - 4395567 bp
Length : 945 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15581575, 9843488; Product type e : enzyme

DNA sequence :
ATGGTCGCAAGCGGCATGGCAGCCCTCGACCTAGCACTCTCGGGGCTTCGGCCTGGAGATCTCCTGGTCGCGCCGCATGA
TTGTTACGGAGGCACTCACCGTCTGCTCAGCCTTCGCAGCGCACGAGGCCATTACCGCGTGGCGTTCGTCGATCAGACGG
ATGGTGAAGCGCTCGCGGCAGCGCTCGCGCTTGAGCCGAAAGTCGTACTCGTCGAGACGCCGAGCAACCCACTGATGCGG
GTGGTCGACATCCGCCACATTACCGGCCTTGCCAAGGCGACCGGCGCCCTCACGGTGGTTGACAACACCTTCCTGTCACC
TGCGCTGCAACAGCCGCTTGCTCTCGGTGCCGACTTGGTCGTCCACTCCACAACCAAATTCCTCAACGGCCACTCCGATG
TTATCGGTGGAGCCGTCATTGCTGCTGACGCCGCGCTCGGCGAAGAACTGGCGGCGTGGGCTAACACCATCGGCGTTACC
GGTTCGCCGCTCGATGCCTATCTCACGCTCCGAGGCGTCCGTACGCTCTTCGTGCGGGTAGAGCGCCAGCAACAGACCGC
CGCGACGCTCGCAGCTTTCCTCGACACGCATCCGGCTGTCAGCCGTGTTCATTACCCGGGCTTGCCCTCTCATCCTGGCC
ACGCGCTCGCAAAGTCACAGCAGAGCGGTTTCGGTGCCATGCTCAGTTTCGAGCTTGCCGGTGGCCTTGCGGCGGTCCGG
ATCCTCGTGGAGGCGCTGCAGGTCTTCACCTTGGCCGAATCCCTCGGCGGCGTCGAGAGCCTGATTGCACACTCGCCAAC
GATGACACACGCTGCGATGGACCCCGAAGCACGTGCAACAGCCGGCATCGCGGACGGGCTAGTTCGACTGTCTGTTGGTC
TTGAAGCCGAAGACGATCTCCTGGCCGATCTTCGTCAAGGATTGGCTGCAGCGGCCAACGTTTGA

Protein sequence :
MVASGMAALDLALSGLRPGDLLVAPHDCYGGTHRLLSLRSARGHYRVAFVDQTDGEALAAALALEPKVVLVETPSNPLMR
VVDIRHITGLAKATGALTVVDNTFLSPALQQPLALGADLVVHSTTKFLNGHSDVIGGAVIAADAALGEELAAWANTIGVT
GSPLDAYLTLRGVRTLFVRVERQQQTAATLAAFLDTHPAVSRVHYPGLPSHPGHALAKSQQSGFGAMLSFELAGGLAAVR
ILVEALQVFTLAESLGGVESLIAHSPTMTHAAMDPEARATAGIADGLVRLSVGLEAEDDLLADLRQGLAAAANV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-42 43
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 5e-41 43
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-40 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_003069943.1 cystathionine gamma-synthase, PLP-dependent BAC0207 Protein 8e-40 46