Gene Information

Name : ureC (METDI3789)
Accession : YP_003069278.1
Strain : Methylobacterium extorquens DM4
Genome accession: NC_012988
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3728974 - 3730701 bp
Length : 1728 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1400317, 1624427, 2211515, 7721685, 7855593, 7909161, 8318888, 8808930; Product type e : enzyme

DNA sequence :
ATGGCCGACATCCGCAAGCCCGCCGCCCTCCCCCGCGCGGCCTACGCCGCCATGTTCGGGCCCACTACCGGCGACCGTAT
CCGGCTGGCCGACACCAGCCTCGAGATTGAGATCGAGCGCGATCTCACGACCTACGGCGAGGAGGTGAAGTTCGGCGGCG
GCAAGGTGATCCGCGACGGGATGGGCCAGTCGCAGGCGACCAACGCCGAGGGCGCCGTCGATACCGTCATCACCAACGCG
GTGGTGCTCGACCATTGGGGCATCGTGAAATGCGATGTCGGTATCCGCGCCGGCCGCATCTTCAAGCTCGGAAAGGCTGG
CAACCCGGACGTTCAGGCCAATGTCGACATCGTCGTCGGCCCCGGCACCGAGGTGATTGCCGGCGAGGGCAAGATCCTCA
CAGCCGGCGGCTTCGACAGCCATATCCACTTCATCTGCCCGCAGCAGATCGAGGAAGCGCTCTGCTCCGGTGTGACGACG
ATGCTGGGTGGCGGTACCGGGCCGGCGCACGGCACCTTCGCCACCACCTGCACCCCCGGCCCCTGGCACATCGCCCGGAT
GATCGAGGCGGCGGATTCCTTCCCGATGAACCTCGCCTTTGCCGGCAAGGGCAATGCCTCGGTGCCCGGCGCGCTGGAAG
AGATGATCCGCGCCGGCGCCTGCGCGATGAAGCTGCACGAGGATTGGGGCACGACGCCCGCCGCGATCGATACCTGCCTC
TCGGTGGCGGACGCCTTCGACGTGCAGGTCATGATCCACACCGACACGCTCAACGAATCGGGCTTCGTCGAGGACACGAT
CGCTGCCTTCAAGGGCCGCACCATCCACGCCTTCCACACCGAGGGCGCCGGCGGCGGCCATGCGCCGGACATCATGCGGG
TCGCCGGCCTCGCGAATGTGCTCCCGTCGTCCACGAACCCGACGCGCCCATACACAAAAAATACCATCGATGAGCATCTC
GACATGCTGATGGTGTGCCACCACCTCGACCCGTCGATCCCTGAAGACCTCGCCTTCGCCGAGAGCCGCATCCGCAAGGA
GACCATCGCGGCCGAGGACATCCTGCACGATATCGGCGCGCTCTCGATGATGTCATCCGACAGTCAGGCGATGGGCCGCG
TCGGCGAAGTCGTGATCCGCACATGGCAGACCGCCGACAAGATGAAGCGCCAGCGCGGCGCCCTGCCCGGAGATGCGTCG
GGCAACGACAACCTGCGCGCCCGTCGCTACGTGGCGAAGTACACGATCAACCCGGCTATCGCGCATGGCGTCTCGCGCCA
TATCGGCTCGGTAGAGCCGGGCAAGCTCGCCGACCTCGTGCTGTGGACGCCCGCCTTCTTCGGCGTGAAGCCGGACCTCG
TGCTCAAGGGCGGCATGATCGCCACCGCGCCGATGGGCGACCCCAACGCCTCGATCCCCACGCCGCAGCCGGTGCATTAC
CGGCCGATGTTCGGCGCCTACGGCCGGGCGCCCTATGCCACCGCGCTCACCTTCGTCTCGCGGGCGGCGCTCGAGGACGG
CGTGAAGGAGAAGCTGCGCGTCTCCAAGGAGCTGGTGGCGGTGGAGAACGTGCGGGGCGGCATCTCGAAGAAGAGCATGA
TCCTCAACGACGCGACCCCGAACATCGAGATCGACCCGGAGACCTACGACGTGCGCGCCGACGGCGAATTGCTGGTCTGC
GAGCCGGCGGAGGTCTTGCCGATGGCGCAGCGCTACTTCCTGTTCTGA

Protein sequence :
MADIRKPAALPRAAYAAMFGPTTGDRIRLADTSLEIEIERDLTTYGEEVKFGGGKVIRDGMGQSQATNAEGAVDTVITNA
VVLDHWGIVKCDVGIRAGRIFKLGKAGNPDVQANVDIVVGPGTEVIAGEGKILTAGGFDSHIHFICPQQIEEALCSGVTT
MLGGGTGPAHGTFATTCTPGPWHIARMIEAADSFPMNLAFAGKGNASVPGALEEMIRAGACAMKLHEDWGTTPAAIDTCL
SVADAFDVQVMIHTDTLNESGFVEDTIAAFKGRTIHAFHTEGAGGGHAPDIMRVAGLANVLPSSTNPTRPYTKNTIDEHL
DMLMVCHHLDPSIPEDLAFAESRIRKETIAAEDILHDIGALSMMSSDSQAMGRVGEVVIRTWQTADKMKRQRGALPGDAS
GNDNLRARRYVAKYTINPAIAHGVSRHIGSVEPGKLADLVLWTPAFFGVKPDLVLKGGMIATAPMGDPNASIPTPQPVHY
RPMFGAYGRAPYATALTFVSRAALEDGVKEKLRVSKELVAVENVRGGISKKSMILNDATPNIEIDPETYDVRADGELLVC
EPAEVLPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 1e-180 67
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 1e-180 67
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 9e-167 63
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-166 63
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-166 63
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-166 63

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_003069278.1 urease subunit alpha VFG0270 Protein 4e-157 61