Gene Information

Name : guaA (Hbal_1810)
Accession : YP_003060193.1
Strain : Hirschia baltica ATCC 59814
Genome accession: NC_012982
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1942805 - 1944388 bp
Length : 1584 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGCTTGCCATGACAGATATACACGACATGAATCACGAAAAAGCGCTGATCATCGACTTTGGTAGTCAGGTGACGCAGCT
CATCGCTCGCCGTCTTCGCGAAAACGGCGTATATTGTGAAATCCACCCTTATCAGAATGTGACGGACGCATCGCTTAAAG
CGTATAATCCCAAAGCGATTATATTCTCTGGTGGTCCAGACTCGGTTATGCGTGAGGGGTCACCAAGACCGCCTAAAGCG
GCTTATGAGTTGGGCGTTCCAATTTTGGGTATCTGTTATGGTCAGCAAGTGATGATGCATGATCTTGGAGGCCGTGTTGA
AGCAGGTGAACATGCAACAGCTGAATTTGGACGTGCCTTCGTAACGCCTTCTTCGAACAAGCTGGACATGCTTGAAGGTT
GGTTTGAAGACGGCAATGAACAGGTCTGGATGTCTCATGGGGACCATGTGGCGGAAAGAGCACCAGGGTTTGAAGTCTAT
GGGACGTCACCGGGTGCACCATTTGCCATAACGGCAGATGTGAAACGTAATTTCTTCGCTGTTCAATTTCATCCTGAAGT
GCACCACACACCCAATGGTAACAAGCTTTATGCCAACTTTCTAAAGCTTGCAGGCTTTAAAGGTGATTGGACGATGGGTG
CTTATCGCGAAGAAGCGATAGCGCGTATCCGCGAGCAAGTTGGTGATAAGCAGGTTATCTGTGGTCTATCTGGCGGTGTG
GATAGCTCTGTGACTGCATTGTTATTGCACCAAGCCATTGGTGATCAGCTGACATGTGTGTTCGTCAATAATGGTTTGCT
TCGCAAGAATGAAGCTGAAGAAGTTGTGGCAATGTTCACTGAGAACTACAAAATCAAGCTCGTCTATGCGGATGAGAGTG
AGTTGTTCTTGGGTGAACTAGAGGGCCAAGATGATCCAGAGACTAAGCGTAAAATAATTGGCCGGCTCTTTATCGATGTT
TTCCAAAAATATGCAGATACAATTGAAGGCGCTGAGTTCCTTGCTCAAGGAACGTTATATCCTGATGTGATTGAATCCGT
CAGCTTTTCTGGTGGTCCGTCCGTCACGATTAAATCACACCACAATGTGGGTGGTTTGCCAGAAAAAATGGGCCTTAAAC
TTGTTGAGCCATTGCGTGAACTTTTCAAGGATGAAGTGCGTATTTTAGGGCGTGAGCTTGGACTACCGCAAAGCTTTATT
GGGCGTCACCCTTTCCCTGGGCCAGGCCTCGCTATTCGTTGTCCTGGATTGATTACGCGTGAGAAACTCGCAATCCTGCG
TGAAGCGGATGCTGTTTACATTGATCAGATCCGTAAACATGGTCTCTATGATGAAATCTGGCAGGCCTATGTTGCAATTC
TACCTGTTCGCACTGTCGGTGTGATGGGAGATGGACGCACTTATGATTATGCGTGTGCTATGCGAGCTGTGACGTCAGTT
GATGGTATGACAGCAGATTATTATCCTTTTTCACACGAGTTTCTTGGTGAAACTGCAACGCGTATCATCAATGAAGTCAA
AGGTATCAATCGAGTCACTTATGACATAACATCGAAACCGCCGGGGACAATTGAGTGGGAATAG

Protein sequence :
MLAMTDIHDMNHEKALIIDFGSQVTQLIARRLRENGVYCEIHPYQNVTDASLKAYNPKAIIFSGGPDSVMREGSPRPPKA
AYELGVPILGICYGQQVMMHDLGGRVEAGEHATAEFGRAFVTPSSNKLDMLEGWFEDGNEQVWMSHGDHVAERAPGFEVY
GTSPGAPFAITADVKRNFFAVQFHPEVHHTPNGNKLYANFLKLAGFKGDWTMGAYREEAIARIREQVGDKQVICGLSGGV
DSSVTALLLHQAIGDQLTCVFVNNGLLRKNEAEEVVAMFTENYKIKLVYADESELFLGELEGQDDPETKRKIIGRLFIDV
FQKYADTIEGAEFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLKLVEPLRELFKDEVRILGRELGLPQSFI
GRHPFPGPGLAIRCPGLITREKLAILREADAVYIDQIRKHGLYDEIWQAYVAILPVRTVGVMGDGRTYDYACAMRAVTSV
DGMTADYYPFSHEFLGETATRIINEVKGINRVTYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-124 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-124 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-124 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-111 49