Gene Information

Name : fliI (HELPY_1389)
Accession : YP_003058040.1
Strain : Helicobacter pylori B38
Genome accession: NC_012973
Putative virulence/resistance : Virulence
Product : flagellum-specific ATP synthase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.14
Position : 1374118 - 1375422 bp
Length : 1305 bp
Strand : -
Note : involved in type III protein export during flagellum assembly

DNA sequence :
ATGCCCCTAAAATCCTTAAAAAACCGCTTGAATCAGCATTTTGATCTATCGCCTCGCTACGGGAGCGTGAAAAAAATCAT
GCCCAATATCGTTTATGCGGATGGTTTTAACCCCTCTGTGGGCGATGTGGTGAAGATTGAAAAAAGCGATGGCAGCGAAT
GCGTGGGAATGGTGGTGGTGGCAGAAAAAGAGCAGTTTGGTTTCACGCCCTTTAACTTTATAGAGGGGGCTAGGGCTGGC
GATAAGGTGCTGTTTTTAAAAGAGGGGTTGAATTTCCCTGTGGGCCGTAATCTTTTAGGGAGGGTGCTTAACCCTCTAGG
GCAAGTCATTGACAATAAGGGGGCGCTAGATTATGAACGATTAGCGCCTGTGATTACAACGCCTATAGCCCCTTTAAAAA
GAGGCTTGATTGATGAGGTTTTTAGCGTGGGGGTGAAGAGCATTGATGGGCTTTTGACTTGCGGTAAGGGGCAAAAACTG
GGCATTTTTGCCGGCTCTGGGGTGGGTAAATCCACGCTAATGGGCATGATCACTAGAGGTTGCTTAGCGCCGATTAAAGT
GATCGCTTTGATTGGGGAAAGGGGCAGAGAAATCCCTGAATTTATAGAGAAAAACTTAAAAGGGGATTTAAGCTCTTGCG
TGTTGGTGGTCGCCACGAGCGATGATAGCCCTTTAATGCGCAAATACGGGGCTTTTTGCGCGATGAGCGTGGCGGAGTAT
TTTAAAAACCAAGGGCTAGACGTGTTATTCATCATGGATTCAGTGACTCGTTTCGCTATGGCTCAAAGAGAAATCGGTTT
AGCCTTAGGCGAACCGCCCACTTCCAAAGGCTACCCCCCATCCGCGCTTTCTTTATTGCCTCAATTGATGGAGAGAGCGG
GCAAGGAAGAAAATAAGGGGAGCATCACGGCTTTTTTTAGCGTGCTAGTAGAGGGCGATGATTTGAGCGATCCCATAGCC
GATCAAGCCAGGAGTATTTTAGATGGGCATATTGTCTTAAGCAGGGAATTGACCGATTATGGGATCTACCCGCCTATTAA
TATTTTAAACTCCGCATCAAGGGTGGCTAAAGACATTACCAGCGAGTCTCAAAACCTTTGCGCGAGAAAATTCCGCCGTT
TGTATGCGTTATTGAAAGAAAATGAAATGCTCATTCGCATCGGATCTTATCAAATGGGGAACGATAAAGAGCTTGATGAA
GCGATTAAGAAAAAGGCTTTAATGGAGCAGTTTTTAGCGCAAGATGAAAACGCTTTGCAGCCTTTTGAACAAAGCTTTCA
GCAATTAGAAGAAATCTTAAGATAA

Protein sequence :
MPLKSLKNRLNQHFDLSPRYGSVKKIMPNIVYADGFNPSVGDVVKIEKSDGSECVGMVVVAEKEQFGFTPFNFIEGARAG
DKVLFLKEGLNFPVGRNLLGRVLNPLGQVIDNKGALDYERLAPVITTPIAPLKRGLIDEVFSVGVKSIDGLLTCGKGQKL
GIFAGSGVGKSTLMGMITRGCLAPIKVIALIGERGREIPEFIEKNLKGDLSSCVLVVATSDDSPLMRKYGAFCAMSVAEY
FKNQGLDVLFIMDSVTRFAMAQREIGLALGEPPTSKGYPPSALSLLPQLMERAGKEENKGSITAFFSVLVEGDDLSDPIA
DQARSILDGHIVLSRELTDYGIYPPINILNSASRVAKDITSESQNLCARKFRRLYALLKENEMLIRIGSYQMGNDKELDE
AIKKKALMEQFLAQDENALQPFEQSFQQLEEILR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 1e-72 50
escN CAC81862.1 EscN protein Virulence LEE II Protein 1e-76 46
escN NP_290268.1 hypothetical protein Virulence LEE Protein 8e-78 46
escN AAC38383.1 EscN Virulence LEE Protein 1e-77 46
ECs4568 NP_312595.1 EscN Virulence LEE Protein 8e-78 46
escN AAC31513.1 L0034 Virulence LEE Protein 6e-78 46
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 6e-78 46
unnamed AAL06369.1 EscN Virulence LEE Protein 1e-76 45
escN AAK26715.1 EscN Virulence LEE Protein 4e-76 45
escN AAL57542.1 EscN Virulence LEE Protein 4e-76 45
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 2e-76 45
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-54 45
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 2e-54 45
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 1e-81 44
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-80 44
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-80 44
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 2e-79 44
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-79 44
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 9e-81 44
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 9e-81 44
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 8e-70 44
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 8e-70 44
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-63 44
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-63 44
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 9e-64 44
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 3e-53 44
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 2e-53 44
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-78 43
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-78 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 3e-59 43
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-77 42
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-76 42
escN CAI43874.1 EscN protein Virulence LEE Protein 9e-77 42
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 3e-58 42
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 1e-58 42
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 5e-59 42
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 1e-71 41
invC AAS66861.1 InvC Not tested SSR-2 Protein 3e-59 41
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 2e-53 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI YP_003058040.1 flagellum-specific ATP synthase VFG0390 Protein 2e-78 52
fliI YP_003058040.1 flagellum-specific ATP synthase VFG0192 Protein 1e-76 51
fliI YP_003058040.1 flagellum-specific ATP synthase VFG0048 Protein 3e-78 50
fliI YP_003058040.1 flagellum-specific ATP synthase VFG2144 Protein 2e-77 47
fliI YP_003058040.1 flagellum-specific ATP synthase VFG0730 Protein 5e-78 46
fliI YP_003058040.1 flagellum-specific ATP synthase VFG0812 Protein 3e-78 46
fliI YP_003058040.1 flagellum-specific ATP synthase VFG1254 Protein 5e-77 45
fliI YP_003058040.1 flagellum-specific ATP synthase VFG0515 Protein 2e-63 44
fliI YP_003058040.1 flagellum-specific ATP synthase VFG2331 Protein 5e-71 42
fliI YP_003058040.1 flagellum-specific ATP synthase VFG1778 Protein 1e-55 42
fliI YP_003058040.1 flagellum-specific ATP synthase VFG1008 Protein 2e-59 41