Gene Information

Name : flu (ECB_02800)
Accession : YP_003045987.1
Strain : Escherichia coli REL606
Genome accession: NC_012967
Putative virulence/resistance : Virulence
Product : antigen 43 (Ag43) phase-variable biofilm formation autotransporter
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG3468
EC number : -
Position : 2999564 - 3002410 bp
Length : 2847 bp
Strand : +
Note : similar to b2000

DNA sequence :
ATGAAACGACATCTGAACACCAGCTACAGGCTGGTATGGAATCACATTACGGGCACCCTGGTGGTGGCTTCCGAACTGGC
CCGCTCACGGGGAAAACGCGCCGGTGTGGCGGTTGCGCTGTCTCTTGCTGCTGTTACGTCAGTCCCGGCACTGGCTGCTG
ACACGGTCGTACAGGCGGGAGAAACCGTGAACGGCGGAACACTGACAAATCATGACAACCAGATTGTCTTCGGTGCGACC
AACGGAATGACCATCAGTACCGGGCTGGAGTATGGGCCGGATAACGAGGCCAATACCGGTGGGCAATGGGTACAGGATGG
CGGCACAGCCAGTAATACCACCATCAGCAGCGGCGGGCTCCAGTTTGTAGGTGCCGGGGGAAAGGCTACAGACACAATAA
TCAATGAAGGAGGCGGACAAAGTCTGAAGGGACTGGCACTGAACACCACGCTGAATGGTGGCGAGCAGTGGATGCATGAA
GGTGCGATAGCCACAGGAACCGTCATTAATGATAAGGGCTGGCAGGTCGTCAAACCCGGCGCAGTGGCAACAGACACCGT
TGTGAATACCGGCGCAGAAGGAGGACCGGATGTAGAAAATGGTGATACCGGGCAGTTTGTTCGCGGAAATGCCGTACGTA
CCACCATCAATGAAAATGGTCGTCAGATTGTGGCTGCTGAAGGAACAGCAAATACCACTGTGGTTTATGCCGGCGGCGAC
CAGACGGTACACGGGCATGCGCTGGATACCACACTGAATGGCGGTTACCAGTATGTGCACAACGGAGGCACAGCCTCTGA
CACGGTTGTAAACAGTGACGGCTGGCAGATTATCAAGGAAGGTGGCCTGGCAAATTTCACCACCGTTAACCAGAAAGGCA
AACTGCAGGTGAACGCCGGTGGTACAGCCACGAATGTCACCCTGAAGCAGGGCGGCGTACTGGTCACCAGTACGGCGGCA
ACCGTCACCGGCAGCAACCGTCTGGGCAATTTCGCGGTGGAAAACGGTAAGGCTGACGGTGTTGTTCTGGAATCCGGCGG
TCGTCTGGATGTACTGGAGAGCCATTCAGCACAGAATACCCTGGTGGATGACGGCGGTACCCTGGCAGTGTCTGCCGGTG
GGCAGGCGACAGGTGTCACCATGACATCTGGTGGTGCCCTGATTGCAGACAGTGGTGCCACTGTTGAGGGGACCAATGCC
AGCGGTAAGTTCAGTATTGATGGCATATCTGGTCAGGCCAGCGGCCTGCTGCTGGAAAATGGCGGCAGCTTTACGGTTAA
TGTCGGGGGACAGGCCAGCAACACCACTGTCGGACATCGTGGAACACTGACGCTGGCTGCCGGGGGAAGTCTGAGTGGCA
GAACACAGCTCAGTAAAGGCGCCAGCATGGTACTGAATGGCGATGTGGTCAGTACCGGCGATATTGTTAACGCAGGGGAG
ATTCGCTTTGATAATCAGACGACACAGGATGCTGCGCTGAGCCGTGCTGTTGCAAAAAGTAACTCCCCGGTAACGTTCCA
TAAACTGACCACCACGAACCTCACCGGCCAGGGCGGCACCATCAATATGCGTGTCAGCCTTGATGGCAGCAATGCCTCTG
ACCAGCTGGTGATTAATGGTGGTCAGGCAACCGGCAAAACCTGGCTTGCGTTTACAAATGTCGGAAATAGTAACCTCGGG
GTGGCAACCTCCGGACAGGGTATCCGGGTTGTGGATGCACAGAATGGCGCCACCACAGAAGAAGGTGCGTTTGCCCTGAG
TCGCCCGCTTCAGGCCGGCGCCTTTAACTACACCCTGAACCGTGACAGCGATGAAGACTGGTACCTGCGCAGTGAAAATG
CTTATCGTGCTGAAGTCCCCCTGTATACATCCATGCTGACACAGGCAATGGACTATGACCGGATTCTGGCAGGCTCCCGC
AGCCATCAGACCGGTGTAAACGGTGAAAATAACAGCGTCCGTCTCAGCATTCAGGGCGGTCATCTCGGTCACGATAACAA
CGGCGGTATTGCCCGTGGGGCCACGCCGGAAAGCAGCGGCAGCTATGGCTTCGTCCGTCTGGAGGGTGACCTGCTCAGAA
CAGAGGTTGCCGGTATGTCTGTGACAGCGGGGGTATATGGTGCTGCCGGCCATTCTTCCGTTGATGTTAAGGATGATGAC
GGCTCCCGCGCCGGCACGGTCCGGGATGATGCCGGCAGTCTGGGCGGATACCTGAATCTGACACACACGTCCTCCGGCCT
GTGGGCTGACATTGTGGCACAGGGAACCCGCCACAGCATGAAAGCGTCATCGGACAATAACGACTTCCGCGCCCGGGGCT
GGGGCTGGCTGGGCTCACTGGAAACCGGTCTGCCCTTCAGTATCACTGACAACCTGATGCTGGAGCCACAACTGCAGTAC
ACCTGGCAGGGGCTCTCCCTGGATGACGGCCAGGATAACGCCGGTTATGTGAAGTTCGGGCATGGCAGTACACAACATGT
GCGTGCCGGCTTCCGTCTGGGCAGCCACAACGATATGACCTTTGGCGAAGGCACCTCATCCCGTGACACTCTGCGCGACA
GTACAAAACACCGTGTGAGTGAACTGCCGGTGAACTGGTGGGTACAGCCTTCTGTTATCCGCACTTTCAGCTCCCGGGGT
GACATGAGCATGGGTACAGCCGCCGCCGGCAGTAACATGACGTTCTCACCGTCCCGGAATGGCACGTCACTGGACCTGCA
GGCCGGACTGGAAGCCCGTGTCCGGGAAAATATCACCCTGGGCGTTCAGGCCGGTTATGCCCACAGCGTCAGCGGCAGCA
GCGCTGAAGGCTATAACGGTCAGGCCACGCTGAATGTGACCTTCTGA

Protein sequence :
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNGGTLTNHDNQIVFGAT
NGMTISTGLEYGPDNEANTGGQWVQDGGTASNTTISSGGLQFVGAGGKATDTIINEGGGQSLKGLALNTTLNGGEQWMHE
GAIATGTVINDKGWQVVKPGAVATDTVVNTGAEGGPDVENGDTGQFVRGNAVRTTINENGRQIVAAEGTANTTVVYAGGD
QTVHGHALDTTLNGGYQYVHNGGTASDTVVNSDGWQIIKEGGLANFTTVNQKGKLQVNAGGTATNVTLKQGGVLVTSTAA
TVTGSNRLGNFAVENGKADGVVLESGGRLDVLESHSAQNTLVDDGGTLAVSAGGQATGVTMTSGGALIADSGATVEGTNA
SGKFSIDGISGQASGLLLENGGSFTVNVGGQASNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
IRFDNQTTQDAALSRAVAKSNSPVTFHKLTTTNLTGQGGTINMRVSLDGSNASDQLVINGGQATGKTWLAFTNVGNSNLG
VATSGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSENAYRAEVPLYTSMLTQAMDYDRILAGSR
SHQTGVNGENNSVRLSIQGGHLGHDNNGGIARGATPESSGSYGFVRLEGDLLRTEVAGMSVTAGVYGAAGHSSVDVKDDD
GSRAGTVRDDAGSLGGYLNLTHTSSGLWADIVAQGTRHSMKASSDNNDFRARGWGWLGSLETGLPFSITDNLMLEPQLQY
TWQGLSLDDGQDNAGYVKFGHGSTQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSTKHRVSELPVNWWVQPSVIRTFSSRG
DMSMGTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSSAEGYNGQATLNVTF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AAL08472.1 putative autotransporter Not tested SRL Protein 0.0 94
unnamed CAE85197.1 antigen43 protein orthologue Not tested PAI V 536 Protein 0.0 93
Z1651 NP_287154.1 adhesin Not tested TAI Protein 0.0 89
Z1211 NP_286746.1 adhesin Not tested TAI Protein 0.0 89
aec67 AAW51750.1 Aec67 Not tested AGI-3 Protein 0.0 65
S3195 NP_838479.1 outer membrane fluffing protein Not tested SHI-1 Protein 0.0 64
aidA ADD91708.1 AidA Not tested PAI-I AL862 Protein 0.0 60
unnamed CAD66200.1 hypothetical protein Virulence PAI III 536 Protein 0.0 59
sap AAK00474.1 Sap Not tested SHI-1 Protein 0.0 58
SF2991 NP_708765.1 outer membrane fluffing protein Not tested SHI-1 Protein 0.0 58
flu CAI43838.1 antigen 43 Not tested LEE Protein 0.0 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
flu YP_003045987.1 antigen 43 (Ag43) phase-variable biofilm formation autotransporter VFG1063 Protein 0.0 94
flu YP_003045987.1 antigen 43 (Ag43) phase-variable biofilm formation autotransporter VFG1675 Protein 0.0 59
flu YP_003045987.1 antigen 43 (Ag43) phase-variable biofilm formation autotransporter VFG0655 Protein 0.0 58