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Name : ureB (TBMG_02145) Accession : YP_003032108.1 Strain : Mycobacterium tuberculosis KZN 1435 Genome accession: NC_012943 Putative virulence/resistance : Virulence Product : urease subunit beta Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0832 EC number : - Position : 2324970 - 2325284 bp Length : 315 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzym DNA sequence : ATGATTCCCGGAGAAATCTTTTACGGCAGTGGTGATATCGAGATGAACGCCGCGGCACTCTCCCGCCTGCAGATGCGGAT CATCAACGCCGGCGATCGTCCGGTGCAGGTCGGTAGCCACGTCCATCTCCCGCAGGCCAATCGGGCGCTGTCATTCGACC GTGCGACGGCCCACGGCTACCGTCTGGACATCCCGGCGGCGACAGCGGTGCGCTTCGAGCCGGGCATTCCCCAAATCGTC GGGTTGGTTCCGTTGGGCGGACGGCGCGAGGTACCCGGTCTGACGCTAAATCCGCCCGGACGGTTGGACCGCTGA Protein sequence : MIPGEIFYGSGDIEMNAAALSRLQMRIINAGDRPVQVGSHVHLPQANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIV GLVPLGGRREVPGLTLNPPGRLDR |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureB | NP_286679.1 | urease subunit beta | Virulence | TAI | Protein | 1e-14 | 50 |
| ureB | NP_287087.1 | urease subunit beta | Not tested | TAI | Protein | 1e-14 | 50 |
| ureB | YP_005686359.1 | Urease beta subunit | Not tested | PiCp 7 | Protein | 2e-16 | 48 |
| ureB | YP_003784326.1 | urease subunit beta | Not tested | PiCp 7 | Protein | 2e-16 | 48 |
| ureB | YP_005682175.1 | Urease beta subunit | Not tested | PiCp 7 | Protein | 2e-16 | 48 |
| ureB | YP_005684267.1 | Urease beta subunit | Not tested | PiCp 7 | Protein | 2e-16 | 48 |
