Gene Information

Name : tpx (NT05HA_0552)
Accession : YP_003007052.1
Strain : Aggregatibacter aphrophilus NJ8700
Genome accession: NC_012913
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 553655 - 554155 bp
Length : 501 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGAGTAACGTTACTTTAGCAGGCAATCCAATCGATGTCGCAGGCCGCTTCCCACAAATTGGCGACCAGCTCACTGAACT
CACATTAGTGAATAATGAATTGGGCGATGTAAATCTAAATACCTTTGCCGGCCAACGCAAAGTACTAAACATTTTCCCAA
GTATCGACACCGGTGTTTGCGCCACCTCCGTGCGTAAATTCAACGAAAAAGCCGCAACATTGGCTAACACCGTTGTACTT
TGCATTTCTGCGGATTTACCTTTCGCACAAATCCGTTTCTGTGGCGCTGAAGGCATCGACAAGGTACAAACCCTTTCCAC
GTTCCGCCACCATGAATTACACAAAACCCTCGGGGTTGACATCACATCCGGCCCTCTCACCGGTCTAACCGCCCGCGCCG
TTATCGTGTTAGATGAACATAACAACGTGCTACACAGCGAATTGGTGTCTGAAATTAAAAACGAGCCGGATTACGACGCT
GCACTTGCCTTGTTAGCCTAA

Protein sequence : 
MSNVTLAGNPIDVAGRFPQIGDQLTELTLVNNELGDVNLNTFAGQRKVLNIFPSIDTGVCATSVRKFNEKAATLANTVVL
CISADLPFAQIRFCGAEGIDKVQTLSTFRHHELHKTLGVDITSGPLTGLTARAVIVLDEHNNVLHSELVSEIKNEPDYDA
ALALLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 1e-34 48
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 9e-35 48
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-34 47
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-34 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_003007052.1 thiol peroxidase VFG0087 Protein 7e-35 47